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Particle Size Reduction of Ramipril Using Cinnamon Oil Based Microemulsion System and Acute Toxicity of the Vehicle in Female Wistar Rats

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Microemulsions as drug delivery vehicles have gained fame for their capability of solubilizing aqueous insoluble drugs with poor bioavailability. Ramipril, one of its kind, was chosen to improve its physico-chemical properties by incorporating in cinnamon oil based microemulsion system. This enabled enhanced solubilization and particle size reduction with mean droplet diameter in the range of 7.2 nm with minimum polydispersity index. The comparison made between the drug-loaded formulation and its blank counterparts demonstrated similarity in the visual appearances, turbidity and viscosity measurements; and very slight increase regarding the pH and conductivity measurements. Owing to the best performance of the drug delivery vehicle, acute toxicity was performed on female Wistar rats. The rats observed no signs of mortality or toxicity at the end of 21 days when a highest volume (1 ml/100 gm body weight) of the vehicle was given orally. Haematological parameters were also observed normal as compared to control rats. The vehicle would place a possible outcome in futuristic work.

Keywords: ACUTE TOXICITY; CINNAMON OIL; DROPLET SIZE; MICROEMULSION; RAMIPRIL; WISTAR RATS

Document Type: Research Article

Publication date: 01 February 2014

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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