DOPC/DPPC Fluid-Gel Phase Segregation in Supported Lipid Membranes Prepared by Fusion on Thiol-Modified Gold Substrates
The formation of lipid bilayers on solid surfaces is a complex mechanism that depends strongly on the roughness, charges and hydrophilicity of the support. Such surfaces modified with lipid bilayers allow to insert functional proteins with the aim to propose membrane-based biosensors
in which the sensing interface is generally composed of gold. In this work, we have examined the ability of dioleoyl-/dipalmitoyl-phosphatidylcholine vesicles to fuse at the surface of gold supports modified with two hydrophilic thiols, one of which was negatively charged. We have evidenced
that the negative charges at the surface of the substrate have a great influence on the presence of defects and on the formation of gel domains in lipid supported bilayers.
Keywords: ATOMIC FORCE MICROSCOPY; BIOMIMETIC MEMBRANES; LIPID PHASES; MEMBRANE FUSION; MODEL LIPID MEMBRANES; SUPPORTED LIPID BILAYERS
Document Type: Research Article
Publication date: 01 December 2014
- Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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