Conclusions
The use of microwave heating in organic synthesis is still in its infancy. The above transformations demonstrate that a large number of fundamental organic reactions can be achieved more rapidly and generally in higher yield using microwave heating than using conventional procedures. Not surprisingly, we expect this area to continue to be the focus of extensive activity.
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References and Notes
A. Abu-Samra, J.S. Morris, and S.R. Koirtyohann, Anal. Chem. 47, 1475 (1975).
a) R.J. Giguere, T.L. Bray, S.M. Duncan, and G. Majetich, Tetrahedron Lett. 27, 4925 (1986); b) R.J. Giguere, A.M. Namen, B.O. Lopez, A. Arepally, D.E. Ramos, G. Majetich, and J. Defauw, Tetrahedron Lett. 28, 6553 (1987).
For other pioneering papers describing microwave accelerated organic reactions, see: a) R. Gedye, F. Smith, H. Westaway, L. Baldisera, L. Laberge, and J. Rousell, Tetrahderon Lett. 27, 279 (1986); b) R.N. Gedye, F.E. Smith, and K.C. Westaway, Can. J. Chem. 66, 17 (1988); c) A.K. Bose, M.S. Manhas, M. Ghosh, V.S. Raju, K. Tabei, and Z. Urbanczyk-Lipowska, Heterocycles 30, 741 (1990); d) D.R. Baghurst and D.M.P. Mingos, J. Chem. Soc. Chem. Comm. 807 (1990); e) Reference 4.
For recent reviews on microwave heating in organic synthesis, see: a) R.A. Abramovitch, Org. Prep. Proceed. Int. 23, 683 (1991); b) D.M. Mingos and D.R. Baghurst, Chem. Soc. Rev. 20, 1 (1991).
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Majetich, G., Hicks, R. Applications of microwave accelerated organic chemistry. Res Chem Intermed 20, 61–77 (1994). https://doi.org/10.1163/156856794X00072
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DOI: https://doi.org/10.1163/156856794X00072