Elsevier

Pancreatology

Volume 5, Issue 6, 2005, Pages 514-529
Pancreatology

Role of inflammation in pancreatic carcinogenesis and the implications for future therapy

https://doi.org/10.1159/000087493Get rights and content

Abstract

Background: The link between inflammation and pancreatic cancer has been observed for a number of gastrointestinal neoplasms. This review examines the role of inflammation in pancreatic carcinogenesis and how it can be utilised to develop new therapies against pancreatic cancer. Methods: A literature review of Pubmed, Medline and Web of Science databases was undertaken using the key words, pancreatic cancer, inflammation, inducible nitric oxide, interleukins, pro-inflammatory cytokines, cyclooxygenase-2, NF-kappa B, reactive oxygen species, DNA adducts, lipoxygenases, chemoprevention. Results: Epidemiological evidence and molecular studies both in vitro and in vivo all support the hypothesis that inflammation plays an important in the initiation and progression of pancreatic tumours. Conclusion: Sustained damage caused by chronic inflammation may precede the onset of frank malignancy by a significant interval. As such, suppression of inflammatory changes and oxidative damage, may help delay or even prevent the inception of pancreatic neoplasia.

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    Giuseppe Garcea, MD Cancer Studies and Molecular Medicine, 5th Floor The Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary Leicester, LE2 7LX (UK) Tel. +44 116 258 4666, Fax +44 116 258 4708

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