1932

Abstract

This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.med.54.101601.152421
2003-02-01
2024-03-28
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.med.54.101601.152421
Loading
/content/journals/10.1146/annurev.med.54.101601.152421
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error