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Annual Review of Pathology: Mechanisms of Disease

Volume 15, 2020

Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of

Abstract

species are environmental gram-negative bacteria able to cause a severe form of pneumonia in humans known as Legionnaires’ disease. Since the identification of in 1977, four decades of research on biology and Legionnaires’ disease have brought important insights into the biology of the bacteria and the molecular mechanisms that these intracellular pathogens use to cause disease in humans. Nowadays, species constitute a remarkable model of bacterial adaptation, with a genus genome shaped by their close coevolution with amoebae and an ability to exploit many hosts and signaling pathways through the secretion of a myriad of effector proteins, many of which have a eukaryotic origin. This review aims to discuss current knowledge of infection mechanisms and future research directions to be taken that might answer the many remaining open questions. This research will without a doubt be a terrific scientific journey worth taking.

Keyword(s): eukaryotic-like proteins, free-living amoeba, Legionella, Legionnaires’ disease

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Erratum: Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of
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2020-01-24
2024-04-18
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Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella
Annual Review of Pathology: Mechanisms of Disease 15, 439 (2020); https://doi.org/10.1146/annurev-pathmechdis-012419-032742
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