短報
成人日本人における同種造血幹細胞移植後の甲状腺機能異常の臨床的特徴
キーワード:
Allogeneic hematopoietic stem cell transplantation,
Thyroid dysfunction,
Chronic graft-versus-host disease
2022 年 63 巻 8 号 p. 876-879
詳細
2022 年 63 巻 8 号 p. 876-879
We examined the incidence and clinical features of thyroid dysfunction in 661 patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in our hospital. At a median of 2.5 (1.0-11.3) years, 28 patients (4.2%) developed subclinical hypothyroidism, and 16 patients (2.4%) developed hypothyroidism. Eight of 16 patients (50%) with hypothyroidism were positive for anti-thyroid antibodies. Ten of 44 patients (22.7%) with thyroid dysfunction were discovered more than 5 years after allo-HSCT. Thyroid dysfunction with late onset was common in allo-HSCT recipients, and thyroid function should be monitored on a regular basis.
