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Efficient calculation of local dose distributions for response modeling in proton and heavier ion beams

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Abstract

We present an algorithm for fast and accurate computation of the local dose distribution in MeV beams of protons, carbon ions or other heavy charged particles. It uses compound Poisson modeling of track interaction and successive convolutions for fast computation. It can handle arbitrary complex mixed particle fields over a wide range of fluences. Since the local dose distribution is the essential part of several approaches to model detector efficiency and cellular response it has potential use in ion-beam dosimetry, radiotherapy, and radiobiology.

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Authors and Affiliations

  1. Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Steffen Greilich

  2. Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000, Aarhus C, Denmark

    Ute Hahn & Markus Kiderlen

  3. Center for Nuclear Technologies, Technical University of Denmark, Risø Campus, 4000, Roskilde, Denmark

    Claus E. Andersen

  4. Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000, Aarhus C, Denmark

    Niels Bassler

Authors
  1. Steffen Greilich
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  2. Ute Hahn
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  3. Markus Kiderlen
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  4. Claus E. Andersen
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  5. Niels Bassler
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Corresponding author

Correspondence to Steffen Greilich.

Additional information

Contribution to the Topical Issue “Nano-scale Insights into Ion-beam Cancer Therapy”, edited by Andrey V. Solov’yov, Nigel Mason, Paulo Limão-Vieira and Malgorzata Smialek-Telega.

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Greilich, S., Hahn, U., Kiderlen, M. et al. Efficient calculation of local dose distributions for response modeling in proton and heavier ion beams. Eur. Phys. J. D 68, 327 (2014). https://doi.org/10.1140/epjd/e2014-40825-0

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  • DOI: https://doi.org/10.1140/epjd/e2014-40825-0

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