Original researchTime since start of first-line therapy as a predictive clinical marker for nintedanib in patients with previously treated non-small cell lung cancer
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Contributors: BG-M, PS, MG, AM, SN, JB, C-NG, MR, NHH and RK contributed to the conception and design of the analysis. MG, AM, SN, MR and NHH were involved in the provision of patients in the trials on which this analysis was based. BG-M, PS, MG, AM, SN, JB, C-NG, MR, NHH, RK and JVH were involved in data analysis and interpretation. BG-M, NHH, JVH and RK jointly prepared the initial draft of the report and contributed equally. All authors actively contributed to subsequent drafts and provided final approval to submit the report for publication. The corresponding author had full access to all the data in the study and final responsibility for the decision to submit for publication.
Disclaimer: This work was presented at the European Cancer Congress 2013(ECCO-ESMO-ESTRO), held in Amsterdam, The Netherlands, 27 September to 1October 2013 (Kaiser R, Barrueco J, Reck M, et al. Identification of a clinicalmarker for second-line combination treatment with nintedanib in adenocarcinomanon-small cell lung cancer (NSCLC) patients in two Phase III trials. AbstractP388).
Funding: The studies on which this analysis was based were sponsored by Boehringer Ingelheim. Analyses were conducted by Boehringer Ingelheim.
Presentation statement: The academic investigators and representatives of the sponsor, Boehringer Ingelheim, co-designed the trials involved in this analysis. The sponsor’s statistical team (of which BG-M and PS are members) performed the statistical analyses. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Competing interests: BG-M, JB, PS and RK are employees of Boehringer Ingelheim. C-NG was an employee of Boehringer Ingelheim at the time this manuscript was developed. RK and BG-M have patents pending for Boehringer Ingelheim. MR has received honoraria for lectures and advisory board meetings from Boehringer Ingelheim Pharma GmbH & Co. KG, Hoffmann-La Roche, Lilly, Pfizer, AstraZeneca, Bristol Myers Squibb and Novartis. AM has received honoraria from Boehringer Ingelheim Pharma GmbH & Co. KG for advisory boards. SN has received non-financial support from Eli Lilly, Roche, AstraZeneca and MSD, during the conduct of this study. NHH and MG have no disclosures to declare. JVH has acted as a consultant for Boehringer Ingelheim, GlaxoSmithKline, AstraZeneca and Genentech, and has received research funding from GlaxoSmithKline and AstraZeneca.
Provenance and peer review: Not commissioned; externally peer reviewed.