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Composites Based on Chitin Nanoparticles and Biodegradable Polymers for Medical Use: Preparation and Properties

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Abstract—

Chitin nanocrystals and nanofibrils possess attractive mechanical and biological properties, which makes them promising for application in different fields. This review discusses the application of chitin nanoparticles as a filler in composites based on biodegradable polymers. Different polymer matrices are considered: synthetic, semisynthetic, and natural (proteins and polysaccharides). Since chitin nanoparticles and nanofibrils possess a high aspect ratio and high Young’s modulus, the main attention is given to the mechanical properties of the composites. Due to the high bioactivity of chitin, composite materials based on it feature interesting biological properties.

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REFERENCES

  1. P. K. Dutta and J. Dutta, Multifaceted Development and Application of Biopolymers for Biology, Biomedicine, and Nanotechnology (Springer, 2013). https://doi.org/10.1007/978-3-642-40123-7

    Book  Google Scholar 

  2. Z. L. McCormick and M. Hooten, Pain Med. 20, 1459 (2019). https://doi.org/10.1093/pm/pny259

    Article  Google Scholar 

  3. Stem Cell-Based Therapy for Lung Disease, Ed. by J. K. Burgess and I. K. Heijink (Springer Nature, Switzerland, 2019). https://doi.org/10.1007/978-3-030-29403-8

    Book  Google Scholar 

  4. T. J. Keane, C.-M. Horejs, and M. M. Stevens, Adv. Drug Deliv. Rev. 129, 407 (2018). https://doi.org/10.1016/j.addr.2018.02.002

    Article  CAS  Google Scholar 

  5. F. C. C. van Rhijn-Brouwer, H. Gremmels, J. O. Fledderus, and M. C. Verhaar, Cell Transplant. 27, 765 (2018). https://doi.org/10.1177/0963689717738257

    Article  CAS  Google Scholar 

  6. A. Atala, R. Lanza, A. G. Mikos, and R. Nerem, Principles of Regenerative Medicine (Academic, Burlington, 2018).

    Google Scholar 

  7. C. Li, C. Guo, V. Fitzpatric, et al., Nat. Rev. Mater. 5, 61 (2020). https://doi.org/10.1038/s41578-019-0150-z

    Article  Google Scholar 

  8. U. G. K. Wegst and M. F. Ashby, Philos. Mag. 84, 2167 (2004). https://doi.org/10.1080/14786430410001680935

    Article  CAS  Google Scholar 

  9. C. Dong and Y. Lv, Polymers 8, 42 (2016). https://doi.org/10.3390/polym8020042

    Article  CAS  Google Scholar 

  10. S. Ahmed, Annu, A. Ali, and J. Sheikh, Int. J. Biol. Macromol. 116, 849 (2018). https://doi.org/10.1016/j.ijbiomac.2018.04.176

    Article  CAS  Google Scholar 

  11. E. Manias, Nat. Mater. 6, 9 (2007).

    Article  CAS  Google Scholar 

  12. D. A. Stone and L. T. J. Korley, Macromolecules 43, 9217 (2010). https://doi.org/10.1021/ma101661p

    Article  CAS  Google Scholar 

  13. B. C. Benicewicz, R. A. Vaia, K. I. Winey, and S. K. Kumar, Macromolecules 50, 714 (2017). https://doi.org/10.1021/acs.macromol.6b02330

    Article  CAS  Google Scholar 

  14. H. K. Nguyen, X. Liang, M. Ito, and K. Nakajima, Macromolecules 51, 6085 (2018). https://doi.org/10.1021/acs.macromol.8b01185

    Article  CAS  Google Scholar 

  15. J. Sun, J. Shen, S. Chen, et al., Polymers 10, 1 (2018). https://doi.org/10.3390/polym10050505

    Article  CAS  Google Scholar 

  16. A. Dufresne, Curr. Opin. Colloid Interface Sci. 29, 1–8 (2017). https://doi.org/10.1016/j.cocis.2017.01.004

    Article  CAS  Google Scholar 

  17. S. Kumar and K. Chatterjee, ACS Appl. Mater. Interfaces 8, 26431 (2016). https://doi.org/10.1021/acsami.6b09801

    Article  CAS  Google Scholar 

  18. J. Wu and P. T. Mather, Polym. Rev. 49, 37 (2009). https://doi.org/10.1080/15583720802656237

    Article  CAS  Google Scholar 

  19. O. I. Bogdanova and S. N. Chvalun, Polym. Sci., Ser. A 58, 629 (2016). https://doi.org/10.1134/S0965545X16050047

    Article  CAS  Google Scholar 

  20. I. Siró and D. Plackett, Cellulose 17, 459 (2010). https://doi.org/10.1007/s10570-010-9405-y

    Article  CAS  Google Scholar 

  21. S. Kaur and G. S. Dhillon, Crit. Rev. Biotechnol. 35, 44 (2015). https://doi.org/10.3109/07388551.2013.798256

    Article  CAS  Google Scholar 

  22. R. Jayakumar, V. V. Divya Rani, K. T. Shalumon, et al., Int. J. Biol. Macromol. 45, 260 (2009). https://doi.org/10.1016/j.ijbiomac.2009.06.002

    Article  CAS  Google Scholar 

  23. K. Azuma, T. Osaki, S. Ifuku, et al., Carbohydr. Polym. 90, 197 (2012). https://doi.org/10.1016/j.carbpol.2012.05.023

    Article  CAS  Google Scholar 

  24. J. Wagener, R. K. S. Malireddi, M. D. Lenardon, et al., PLOS Patogens 10, 1 (2014). https://doi.org/10.1371/journal.ppat.1004050

    Article  Google Scholar 

  25. R. Singh, K. Shitiz, and A. Singh, Int. Wound J. 14, 1276 (2017). https://doi.org/10.1111/iwj.12797

    Article  Google Scholar 

  26. J. Dutta, S. Tripathi, and P. K. Dutta, Food Sci. Technol. Int. 18, 3 (2012). https://doi.org/10.1177/1082013211399195

    Article  CAS  Google Scholar 

  27. S. S. Bari, A. Chatterjee, and S. Mishra, Polym. Rev. 56, 287 (2016). https://doi.org/10.1080/15583724.2015.1118123

    Article  CAS  Google Scholar 

  28. H. Seyednejad, A. H. Ghassemi, C. F. van Nostrum, et al., J. Control. Release 152, 168 (2011). https://doi.org/10.1016/j.jconrel.2010.12.016

    Article  CAS  Google Scholar 

  29. S. Fujisawa, T. Saito, S. Kimura, et al., Biomacromolecules 14, 1541 (2013). https://doi.org/10.1021/bm400178m

    Article  CAS  Google Scholar 

  30. C. Li, H. Liu, B. Luo, et al., Eur. Polym. J. 81, 266 (2016). https://doi.org/10.1016/j.eurpolymj.2016.06.015

    Article  CAS  Google Scholar 

  31. M. Mincea, A. Negrulescu, and V. Ostafe, Rev. Adv. Mater. Sci. 30, 225 (2012).

    CAS  Google Scholar 

  32. K. Missoum, N. M. Belgacem, and J. Bras, Materials (Basel) 6, 1745 (2013). https://doi.org/10.3390/ma6051745

    Article  Google Scholar 

  33. Y. Habibi, Chem. Soc. Rev. 43, 1519 (2014). https://doi.org/10.1039/c3cs60204d

    Article  CAS  Google Scholar 

  34. K. G. Nair, A. Dufresne, A. Gandini, and N. M. Belgacem, Biomacromolecules 4, 1835 (2003). https://doi.org/10.1021/bm030058g

    Article  CAS  Google Scholar 

  35. Y. Chen, L. M. Geever, and J. A. Killion, Polym. Plast. Technol. Eng. 55, 1057 (2016). https://doi.org/10.1080/03602559.2015.1132465

    Article  CAS  Google Scholar 

  36. M. Murariu and P. Dubois, Adv. Drug Deliv. Rev. 107, 17 (2016). https://doi.org/10.1016/j.addr.2016.04.003

    Article  CAS  Google Scholar 

  37. P. B. Maurus and C. C. Kaeding, Oper. Tech. Sports Med. 12, 158 (2004). https://doi.org/10.1053/j.otsm.2004.07.015

    Article  Google Scholar 

  38. T. Patrício, M. Domingos, A. Gloria, et al., Rapid Prototyp. J. 20, 145 (2014). https://doi.org/10.1108/RPJ-04-2012-0037

    Article  Google Scholar 

  39. N. Herrera, A. M. Salaberria, A. P. Mathew, and K. Oksman, Composites, Part A 83, 89 (2016). https://doi.org/10.1016/j.compositesa.2015.05.024

    Article  CAS  Google Scholar 

  40. R. Rizvi, B. Cochrane, H. Naguib, and P. C. Lee, J. Cell. Plast. 47, 283 (2011). https://doi.org/10.1177/0021955X11402549

    Article  CAS  Google Scholar 

  41. N. Herrera, H. Roch, A. M. Salaberria, et al., Mater. Des. 92, 846 (2016). https://doi.org/10.1016/j.matdes.2015.12.083

    Article  CAS  Google Scholar 

  42. A. M. Salaberria, R. H. Diaz, M. A. Andrés, et al., Materials (Basel) 10, 1 (2017). https://doi.org/10.3390/ma10050546

    Article  CAS  Google Scholar 

  43. Q. Zhang, S. Wei, J. Huang, et al., J. Appl. Polym. Sci. 131, 2 (2014). https://doi.org/10.1002/app.39809

    Article  CAS  Google Scholar 

  44. H. Liu, W. Liu, B. Luo, et al., Carbohydr. Polym. 147, 216 (2016). https://doi.org/10.1016/J.CARBPOL.2016.03.096

    Article  CAS  Google Scholar 

  45. H. Lee, S. M. Dellatore, W. M. Miller, and P. B. Mes-sersmith, Science (Washington, DC, U. S.) 318, 426 (2017). https://doi.org/10.1126/science.1147241

    Article  CAS  Google Scholar 

  46. W. Liu, L. Zhu, Y. Ma, et al., Carbohydr. Polym. 212, 277 (2019). https://doi.org/10.1016/j.carbpol.2019.02.060

    Article  CAS  Google Scholar 

  47. S. C. Cowin, Bone Mechanics Handbook, 2nd ed. (CRC, Boca Raton, 2001).

    Book  Google Scholar 

  48. N. Herrera, A. A. Singh, A. M. Salaberria, et al., Polymers (Basel) 9, 406 (2017). https://doi.org/10.3390/polym9090406

    Article  CAS  Google Scholar 

  49. M. B. Coltelli, P. Cinelli, V. Gigante, et al., Int. J. Mol. Sci. 20, 504 (2019). https://doi.org/10.3390/ijms20030504

    Article  CAS  Google Scholar 

  50. H. J. Krause, A. Schwarz, and P. Rohdewald, Int. J. Pharm. 27, 145 (1985). https://doi.org/10.1016/0378-5173(85)90064-X

    Article  CAS  Google Scholar 

  51. B. Tyler, D. Gullotti, A. Mangraviti, et al., Adv. Drug Deliv. Rev. 107, 163 (2016). https://doi.org/10.1016/j.addr.2016.06.018

    Article  CAS  Google Scholar 

  52. V. Lassalle and M. L. Ferreira, Macromol. Biosci. 7, 767 (2007). https://doi.org/10.1002/mabi.200700022

    Article  CAS  Google Scholar 

  53. C. Rouzes, M. Leonard, A. Durand, and E. Dellacherie, Colloids Surf., B 32, 125 (2003). https://doi.org/10.1016/S0927-7765(03)00152-8

    Article  CAS  Google Scholar 

  54. E. V. Razuvaeva, A. I. Kulebyakina, D. R. Streltsov, et al., Langmuir 34, 15470 (2018). https://doi.org/10.1021/acs.langmuir.8b03379

    Article  CAS  Google Scholar 

  55. Z. Zhu, Biomaterials 34, 10238 (2013). https://doi.org/10.1016/j.biomaterials.2013.09.015

    Article  CAS  Google Scholar 

  56. C. Nouvel, J. Raynaud, E. Marie, et al., J. Colloid Interface Sci. 330, 337 (2009). https://doi.org/10.1016/j.jcis.2008.10.069

    Article  CAS  Google Scholar 

  57. T. S. Demina, Y. S. Sotnikova, A. V. Istomin, et al., Adv. Mater. Sci. Eng. 2018, 8518016 (2018). https://doi.org/10.1155/2018/8518016

    Article  CAS  Google Scholar 

  58. K. V. Malafeev, O. A. Moskalyuk, V. E. Yudin, et al., J. Appl. Cosmetol. 35, 163 (2017).

    Google Scholar 

  59. P. Gunatillake, R. Mayadunne, and R. Adhikari, Biotechnol. Ann. Rev. 12, 301 (2006). https://doi.org/10.1016/S1387-2656(06)12009-8

    Article  CAS  Google Scholar 

  60. L. S. Nair and C. T. Laurencin, Prog. Polym. Sci. 32, 762 (2007). https://doi.org/10.1016/j.progpolymsci.2007.05.017

    Article  CAS  Google Scholar 

  61. S. H. Oh, I. K. Park, J. M. Kim, and J. H. Lee, Biomacromolecules 28, 1664 (2007). https://doi.org/10.1016/j.biomaterials.2006.11.024

    Article  CAS  Google Scholar 

  62. M. E. Hoque, W. Y. San, F. Wei, et al., Tissue Eng., A 15, 3013 (2009). https://doi.org/10.1089/ten.tea.2008.0355

    Article  CAS  Google Scholar 

  63. J.-H. Jo, E. J. Lee, D. S. Shin, et al., J. Biomed. Mater. Res. B 91, 213 (2009). https://doi.org/10.1002/jbm.b.31392

    Article  CAS  Google Scholar 

  64. J. P. Chen and Y. S. Chang, Colloids Surf., B 86, 169 (2011). https://doi.org/10.1016/j.colsurfb.2011.03.038

    Article  CAS  Google Scholar 

  65. M. Diba, M. H. Fathi, and M. Kharaziha, Mater. Lett. 65, 1931 (2011). https://doi.org/10.1016/j.matlet.2011.03.047

    Article  CAS  Google Scholar 

  66. K. Saeed, S. Y. Park, H. J. Lee, et al., Polymer 47, 8019 (2006). https://doi.org/10.1016/j.polymer.2006.09.012

    Article  CAS  Google Scholar 

  67. J. O. Zoppe, M. S. Peresin, Y. Habibi, et al., ACS Appl. Mater. Interfaces 1, 1996 (2009). https://doi.org/10.1021/am9003705

    Article  CAS  Google Scholar 

  68. M. Fadaie, E. Mirzaei, B. Geramizadeh, and Z. Asvar, Carbohydr. Polym. 199, 628 (2018). https://doi.org/10.1016/j.carbpol.2018.07.061

    Article  CAS  Google Scholar 

  69. A. Morin and A. Dufresne, Macromolecules 35, 2190 (2002). https://doi.org/10.1021/ma011493a

    Article  CAS  Google Scholar 

  70. L. Feng, Z. Zhou, A. Dufresne, et al., J. Appl. Polym. Sci. 112, 2830 (2009). https://doi.org/10.1002/app.29731

    Article  CAS  Google Scholar 

  71. Y. L. Ji, P. S. Wolfe, I. A. Rodriguez, and G. L. Bowlin, Carbohydr. Polym. 87, 2313 (2012). https://doi.org/10.1016/j.carbpol.2011.10.066

    Article  CAS  Google Scholar 

  72. Y. L. Ji, K. Liang, X. Shen, and G. L. Bowlin, Carbohydr. Polym. 101, 68 (2014). https://doi.org/10.1016/j.carbpol.2013.09.012

    Article  CAS  Google Scholar 

  73. T. D. Prior, D. L. Grace, J. B. MacLean, et al., Foot 7, 121 (1997). https://doi.org/10.1016/S0958-2592(97)90020-1

    Article  Google Scholar 

  74. L. Zhu, K. Liang, and Y. Ji, J. Mech. Behav. Biomed. Mater. 44, 35 (2015). https://doi.org/10.1016/j.jmbbm.2014.12.019

    Article  CAS  Google Scholar 

  75. R. F. Storey, J. S. Wiggins, and A. D. Puckett, J. Polym. Sci. 32, 2345 (1991). https://doi.org/10.1002/pola.1994.080321216

    Article  Google Scholar 

  76. L. Yang, S. Korom, M. Welti, et al., Eur. J. Cardio-Thoracic Surg. 24, 201 (2003). https://doi.org/10.1016/S1010-7940(03)00263-X

    Article  CAS  Google Scholar 

  77. K. Benhamou, H. Kaddami, A. Magnin, et al., Carbohydr. Polym. 122, 202 (2015). https://doi.org/10.1016/j.carbpol.2014.12.081

    Article  CAS  Google Scholar 

  78. B. K. Jackson, A. J. Bow, G. Kannarpady, et al., J. Biomater. Sci. Polym. Ed. 29, 1426 (2018). https://doi.org/10.1080/09205063.2018.1464264

    Article  CAS  Google Scholar 

  79. G. Tetteh, A. S. Khan, R. N. Delaine-Smith, et al., J. Mech. Behav. Biomed. Mater. 39, 95 (2014). https://doi.org/10.1016/j.jmbbm.2014.06.019

    Article  CAS  Google Scholar 

  80. J. Huang, J. W. Zou, P. R. Chang, et al., Express Polym. Lett. 5, 362 (2011). https://doi.org/10.3144/expresspolymlett.2011.35

    Article  CAS  Google Scholar 

  81. J. O. Akindoyo, M. D. H. Beg, S. Ghazali, et al., RSC Adv. 6, 114453 (2016). .https://doi.org/10.1039/C6RA14525F

    Article  CAS  Google Scholar 

  82. N. Lin, S. Wei, T. Xia, et al., RSC Adv. 4, 49098 (2014). https://doi.org/10.1039/c4ra07899c

    Article  CAS  Google Scholar 

  83. M. Zeng, H. Gao, Y. Wu, et al., J. Macromol. Sci. A 47, 37 (2010). https://doi.org/10.1080/10601325.2010.492277

    Article  CAS  Google Scholar 

  84. A. Saralegi, S. C. M. Fernes, and A. Alonso-Varona, et al., Biomacromolecules 14, 4475 (2013). https://doi.org/10.1021/bm401385c

    Article  CAS  Google Scholar 

  85. T. Calvo-Correas, P. Garrido, A. Alonso-Varona, et al., J. Appl. Polym. Sci. 136, 47430 (2019). https://doi.org/10.1002/app.47430

    Article  CAS  Google Scholar 

  86. J. L. Shamshina, O. Zavgorodnya, P. Berton, et al., ACS Sustain. Chem. Eng. 6, 10241 (2018). https://doi.org/10.1021/acssuschemeng.8b01554

    Article  CAS  Google Scholar 

  87. J. Chakravarty, M. F. Rabbi, V. Chalivendra, et al., Int. J. Biol. Macromol. 151, 1213 (2020). https://doi.org/10.1016/j.ijbiomac.2019.10.168

    Article  CAS  Google Scholar 

  88. A. Anitha, S. Sowmya, P. T. S. Kumar, et al., Prog. Polym. Sci. 39, 1644 (2014). https://doi.org/10.1016/j.progpolymsci.2014.02.008

    Article  CAS  Google Scholar 

  89. T. R. Arunraj, N. S. Rejinold, N. A. Kumar, and R. Jayakumar, Colloids Surf., B 113, 394 (2014). https://doi.org/10.1016/j.colsurfb.2013.09.023

    Article  CAS  Google Scholar 

  90. M. S. Kim, S. J. Park, B. K. Gu, and C. H. Kim, J. Nanomater. 2012, 1 (2012). https://doi.org/10.1155/2012/635212

    Article  CAS  Google Scholar 

  91. K. E. Park, H. K. Kang, S. J. Lee, et al., Biomacromolecules 7, 635 (2006). https://doi.org/10.1021/bm0509265

    Article  CAS  Google Scholar 

  92. B. M. Min, Y. You, J. M. Kim, et al., Carbohydr. Polym. 57, 285 (2004). https://doi.org/10.1016/j.carbpol.2004.05.007

    Article  CAS  Google Scholar 

  93. N. S. Rejinold, R. Biswas, G. Chellan, and R. Jayakumar, Int. J. Biol. Macromol. 67, 279 (2014). https://doi.org/10.1016/j.ijbiomac.2014.03.037

    Article  CAS  Google Scholar 

  94. A. Sivashanmugam, P. Charoenlarp, S. Deepthi, et al., ACS Appl. Mater. Interfaces 9, 42639 (2017). https://doi.org/10.1021/acsami.7b15845

    Article  CAS  Google Scholar 

  95. S. Deepthi, C. V. S. Viha, C. Thitirat, et al., Polymers 6, 2974 (2014). https://doi.org/10.3390/polym6122974

    Article  CAS  Google Scholar 

  96. J. Lu, R. C. Tappel, and C. T. Nomura, Polym. Rev. 49, 37 (2009). https://doi.org/10.1080/15583720903048243

    Article  CAS  Google Scholar 

  97. B. Laycock, P. Halley, S. Pratt, et al., Prog. Polym. Sci. 38, 536 (2013). https://doi.org/10.1016/j.progpolymsci.2012.06.003

    Article  CAS  Google Scholar 

  98. E. Ten, L. Jiang, J. Zhang, and M. P. Wolcott, Biocomposites, 39 (2015). https://doi.org/10.1016/B978-1-78242-373-7.00008-1

  99. J. Wang, Z. Wang, J. Li, et al., Carbohydr. Polym. 87, 784 (2012). https://doi.org/10.1016/j.carbpol.2011.08.066

    Article  CAS  Google Scholar 

  100. B. Wang, J. Li, J. Zhang, et al., Carbohydr. Polym. 95, 100 (2013). https://doi.org/10.1016/j.carbpol.2013.02.055

    Article  CAS  Google Scholar 

  101. H. Y. Li, H. Li, B. Wang, et al., Chin. Chem. Lett. 25, 1635 (2014). https://doi.org/10.1016/j.cclet.2014.06.019

    Article  CAS  Google Scholar 

  102. Q. Guan and H. E. Naguib, J. Polym. Environ. 22, 119 (2014). https://doi.org/10.1007/s10924-013-0625-8

    Article  CAS  Google Scholar 

  103. D. L. Kaplan, Biopolymers from Renewable Resources, 1st ed. (Springer, Berlin, 1998). https://doi.org/10.10007/978-3-662-04068-3

    Book  Google Scholar 

  104. A. Dufresne, S. Thomas, and L. A. Pothan, Biopolymer Nanocompocites: Processing, Properties, and Applications (Wiley, New York, 2013).

    Book  Google Scholar 

  105. J. Brandrup, E. H. Immergut, and E. A. Grulke, Polymer Handbook, 4th ed. (Wiley, New York, 1999).

    Google Scholar 

  106. Y. Zhang, C. Rempel, and Q. Liu, Crit. Rev. Food Sci. Nutr. 54, 1353 (2014). https://doi.org/10.1080/10408398.2011.636156

    Article  CAS  Google Scholar 

  107. M. Chieruzzi, S. Pagano, S. Moretti, et al., Nanomaterials 6, 134 (2016). https://doi.org/10.3390/nano6070134

    Article  CAS  Google Scholar 

  108. M. I. A. Rodríguez, L. G. Rodríguez Barroso, and M. L. Sánchez, J. Cosmet. Dermatol. 17, 20 (2018). https://doi.org/10.1111/jocd.12450

    Article  Google Scholar 

  109. A. Gaspar-Pintiliescu, A.-M. Stanciuc, and O. Craciunescu, Int. J. Biol. Macromol. 138, 854 (2019). https://doi.org/10.1016/j.ijbiomac.2019.07.155

    Article  CAS  Google Scholar 

  110. T. Kh. Tenchurin, S. I. Belousov, Y. I. Kiryukhin, et al., J. Biomed. Mater. Res. A 107, 312 (2019). https://doi.org/10.1002/jbm.a.36459

    Article  CAS  Google Scholar 

  111. M. D. Shoulders and R. T. Raines, Ann. Rev. Biochem. 78, 929 (2009). https://doi.org/10.1146/annurev.biochem.77.032207.120833

    Article  CAS  Google Scholar 

  112. A.-M. Haaparanta, E. Jarvinen, I. F. Cengiz, et al., J. Mater. Sci.: Mater. Med. 25, 1129 (2014). https://doi.org/10.1007/s10856-013-5129-5

    Article  CAS  Google Scholar 

  113. V. Y. Chakrapani, A. Gnanamani, V. R. Giridev, et al., J. Appl. Polym. Sci. 125, 3221 (2012). https://doi.org/10.1002/app.36504

    Article  CAS  Google Scholar 

  114. A. P. H. Rodrigues, I. M. Pereira, S. D. de Souza, et al., Cellulose 24, 1731 (2017). https://doi.org/10.1007/s10570-017-1218-9

    Article  CAS  Google Scholar 

  115. Y. Huang, Y. Wang, L. Chen, and L. Zhang, J. Mater. Chem. B 6, 918 (2018). https://doi.org/10.1039/C7TB02945D

    Article  CAS  Google Scholar 

  116. Y. Huang, Y. Fang, L. Chen, et al., Chem. Eng. J. 315, 573 (2017). https://doi.org/10.1016/j.cej.2017.01.065

    Article  CAS  Google Scholar 

  117. Y. Shen, L. Dai, X. Li, et al., PLOS One 9, 1 (2014). https://doi.org/10.1371/journal.pone.0087557

    Article  CAS  Google Scholar 

  118. G. H. Altman, F. Diaz, C. Jakuba, et al., Biomaterials 24, 401 (2003). https://doi.org/10.1016/S0142-9612(02)00353-8

    Article  CAS  Google Scholar 

  119. H. K. Soong and K. R. Kenyon, Ophthalmology 91, 479 (1984). https://doi.org/10.1016/S0161-6420(84)34273-7

    Article  CAS  Google Scholar 

  120. L. Meinel, S. Hofmann, V. Karageorgiou, et al., Biomaterials 26, 147 (2005). https://doi.org/10.1016/j.biomaterials.2004.02.047

    Article  CAS  Google Scholar 

  121. B. Bondar, S. Fuchs, A. Motta, et al., Biomaterials 29, 561 (2008). https://doi.org/10.1016/j.biomaterials.2007.10.002

    Article  CAS  Google Scholar 

  122. G. Carrasco-Torres, M. A. Valdés-Madrigal, V. R. Vás-quez-Garzón, et al., Polymers 11, 451 (2019). https://doi.org/10.3390/polym11030451

    Article  CAS  Google Scholar 

  123. B. Levin, S. L. Redmond, R. Rajkhowa, et al., J. Laryngol. Otol. 127, 13 (2013). https://doi.org/10.1017/S0022215112001661

    Article  Google Scholar 

  124. M. Hirata, M. Kobayashi, C. Matsumoto, et al., J. Health Sci. 56, 738 (2010). https://doi.org/10.1248/jhs.56.738

    Article  CAS  Google Scholar 

  125. H. Yamada, Y. Igarashi, and Y. Takasu, Biomaterials 25, 467 (2004). https://doi.org/10.1016/S0142-9612(03)00540-4

    Article  CAS  Google Scholar 

  126. A. Nisal, R. Sayyad, P. Dhavale, et al., Sci. Rep. 8, 7235 (2018). https://doi.org/10.1038/s41598-018-25643-x

    Article  CAS  Google Scholar 

  127. P. Wongpanit, N. Sanchavanakit, P. Pavasant, et al., Eur. Polym. 43, 4123 (2007). https://doi.org/10.1016/j.eurpolymj.2007.07.004

    Article  CAS  Google Scholar 

  128. A. M. Salaberria, R. H. Diaz, J. Labidi, et al., Food Hydrocoll. 46, 93 (2015). https://doi.org/10.1016/j.foodhyd.2014.12.016

    Article  CAS  Google Scholar 

  129. A. Aguilar, N. Zein, E. Harmouch, et al., Molecules 24, 3009 (2019). https://doi.org/10.3390/molecules24163009

    Article  CAS  Google Scholar 

  130. B. Sultankulov, D. Berillo, K. Sultankulova, et al., Biomolecules 9, 470 (2019). https://doi.org/10.3390/biom9090470

    Article  CAS  Google Scholar 

  131. M. St?cepniewski, J. Martynkiewicz, and J. Gosk, Polym. Med. 47, 49 (2017). https://doi.org/10.17219/pim/76517

  132. J. P. Quiñones, H. Peniche, and C. Peniche, Polymers 10, 325 (2018). https://doi.org/10.3390/polym10030235

    Article  CAS  Google Scholar 

  133. A. Ali and S. Ahmed, Int. J. Biol. Macromol. 109, 273 (2017). https://doi.org/10.1016/j.ijbiomac.2017.12.078

    Article  CAS  Google Scholar 

  134. M. Bak, O. N. Gutkowska, E. Wagner, and J. Gosk, Polym. Med. 47, 43 (2017). https://doi.org/10.17219/pim/75653

    Article  Google Scholar 

  135. S. Gnavi, Ch. Barwig, Th. Freier, et al., Int. Rev. Neurobiol. 109, 1 (2013). https://doi.org/10.1016/B978-0-12-420045-6.00001-8

    Article  Google Scholar 

  136. K. Azuma, S. Ifuku, T. Osaki, et al., J. Biomed. Nanotechnol. 10, 2891 (2014). https://doi.org/10.1166/jbn.2014.1882

    Article  CAS  Google Scholar 

  137. M. Rodríguez-Vázquez, B. Vega-Ruiz, R. Ramos-Zúñiga, et al., BioMed Res. Int. 2015, 1 (2015). https://doi.org/10.1155/2015/821279

    Article  CAS  Google Scholar 

  138. A. C. A. Wan, and B. C. U. Tai, Biotechnol. Adv. 31, 1776 (2013). https://doi.org/10.1016/j.biotechadv.2013.09.007

    Article  CAS  Google Scholar 

  139. V. E. Yudin, I. P. Dobrovolskaya, I. M. Neelov, et al., Carbohydr. Polym. 108, 176 (2014). https://doi.org/10.1016/j.carbpol.2014.02.090

    Article  CAS  Google Scholar 

  140. J. Araki, Y. Yamanaka, and K. Ohkawa, Polym. J. 44, 713 (2012). https://doi.org/10.1038/pj.2012.11

    Article  CAS  Google Scholar 

  141. G. Xia, Y. Liu, M. Tian, et al., J. Mater. Chem. B 5, 3172 (2017). https://doi.org/10.1039/C7TB00479F

    Article  CAS  Google Scholar 

  142. J. Pang, S. Bi, T. Kong, et al., Carbohydr. Polym. 237, 116138 (2020). https://doi.org/10.1016/j.carbpol.2020.116138

    Article  CAS  Google Scholar 

  143. Q. Wang, S. Chen, and D. Chen, J. Mech. Behav. Biomed. Mater. 65, 466 (2017). https://doi.org/10.1016/j.jmbbm.2016.09.009

    Article  CAS  Google Scholar 

  144. N. Naseri, C. Algan, V. Jacobs, et al., Carbohydr. Polym. 109, 7 (2014). https://doi.org/10.1016/j.carbpol.2014.03.031

    Article  CAS  Google Scholar 

  145. N. Naseri, A. P. Mathew, and K. Oksman, Carbohydr. Polym. 147, 464 (2016). https://doi.org/10.1016/j.carbpol.2016.04.018

    Article  CAS  Google Scholar 

  146. I. P. Dobrovolskaya, V. E. Yudin, P. V. Popryadukhin, et al., Carbohydr. Polym. 194, 260 (2018). https://doi.org/10.1016/j.carbpol.2018.03.074

    Article  CAS  Google Scholar 

  147. A. Pangon, S. Saesoo, N. Saengkrit, et al., Carbohydr. Polym. 144, 419 (2016). https://doi.org/10.1016/j.carbpol.2016.02.053

    Article  CAS  Google Scholar 

  148. J. Sriupayo, P. Supaphol, J. Blackwell, and R. Rujiravanit, Carbohydr. Polym. 62, 130 (2005). https://doi.org/10.1016/j.carbpol.2005.07.013

    Article  CAS  Google Scholar 

  149. A. P. Mathew, M.-P. G. Laborie, and K. Oksman, Biomacromolecules 10, 1627 (2009). https://doi.org/10.1021/bm9002199

    Article  CAS  Google Scholar 

  150. S. Ifuku, A. Ikuta, M. Egusa, et al., Carbohydr. Polym. 98, 1198 (2013). https://doi.org/10.1016/j.carbpol.2013.07.033

    Article  CAS  Google Scholar 

  151. B. Ma, A. Qin, X. Li, et al., Int. J. Biol. Macromol. 64, 341 (2014). https://doi.org/10.1016/j.ijbiomac.2013.12.015

    Article  CAS  Google Scholar 

  152. N. E. Mushi, S. Utsel, and L. A. Berglund, Front. Chem. 2, 1 (2014). https://doi.org/10.3389/fchem.2014.00099

    Article  CAS  Google Scholar 

  153. A. M. Salaberria, R. H. Diaz, J. Labidi, and S. C. M. Fernandes, React. Funct. Polym. 89, 31 (2015). https://doi.org/10.1016/j.reactfunctpolym.2015.03.003

    Article  CAS  Google Scholar 

  154. C. F. C. João, C. Echeverria, A. Velhinho, et al., Carbohydr. Polym. 155, 372 (2017). https://doi.org/10.1016/j.carbpol.2016.08.039

    Article  CAS  Google Scholar 

  155. N. V. Smirnova, K. A. Kolbe, E. N. Dresvyanina, et al., Materials 12, 1874 (2019). https://doi.org/10.3390/ma12111874

    Article  CAS  Google Scholar 

  156. V. V. Kiroshka, V. A. Petrova, D. D. Chernyakov, et al., J. Mater. Sci. Mater. Med. 28, 1 (2017). https://doi.org/10.1007/s10856-016-5822-2

    Article  CAS  Google Scholar 

  157. V. Zubillaga, A. M. Salaberria, T. Palomares, et al., Biomacromolecules 19, 3000 (2018). https://doi.org/10.1021/acs.biomac.8b00570

    Article  CAS  Google Scholar 

  158. D. Suzuki, M. Takahashi, M. Abe, et al., J. Mater. Sci. Med. 19, 1307 (2008). https://doi.org/10.1007/s10856-007-3245-9

    Article  CAS  Google Scholar 

  159. Y. C. Kuo and C. Y. Lin, Biotechnol. Bioeng. 95, 132 (2006). https://doi.org/10.1002/bit.21007

    Article  CAS  Google Scholar 

  160. Y. C. Kuo and I. N. Ku, Biomacromolecules 9, 2662 (2008). https://doi.org/10.1021/bm800651r

    Article  CAS  Google Scholar 

  161. Y. C. Kuo and C. C. Lin, Colloids Surf., B 103, 595 (2013). https://doi.org/10.1016/j.colsurfb.2012.11.001

    Article  CAS  Google Scholar 

  162. M. Liu, H. Zheng, and J. Chen, Carbohydr. Polym. 152, 832 (2016). https://doi.org/10.1016/j.carbpol.2016.07.042

    Article  CAS  Google Scholar 

  163. Yu. Nishioka, S. Kyotani, M. Okamura, et al., Chem. Pharm. Bull. 38, 2871 (1990). https://doi.org/10.1248/cpb.38.2871

    Article  CAS  Google Scholar 

  164. U. V. Singh and N. Udupa, J. Microencapsul. 15, 581 (1998). https://doi.org/10.3109/02652049809008242

    Article  CAS  Google Scholar 

  165. X. Su, M. Tan, B. Duan, et al., J. Mater. Chem. B 7, 5190 (2019). https://doi.org/10.1039/c9tb01046g

    Article  CAS  Google Scholar 

  166. M.-H. Alves, B. E. B. Jensen, A. A. A. Smith, and A. N. Zelikin, Macromol. Biosci. 11, 1293 (2011). https://doi.org/10.1002/mabi.201100145

    Article  CAS  Google Scholar 

  167. E. Chiellini, A. Corti, S. D. Antone, and R. Solaro, Prog. Polym. Sci. 26, 963 (2003). https://doi.org/10.1016/S0079-6700(02)00149-1

    Article  CAS  Google Scholar 

  168. V. Zubillaga, A. Alonso-Varona, S. C. M. Fernandes, et al., Int. J. Mol. Sci. 21, 1004 (2020). https://doi.org/10.3390/ijms21031004

    Article  CAS  Google Scholar 

  169. T. Liebert, Cellulose Solvents—Remarkable History, Bright Future (Am. Chem. Soc., Washington, 2010), Ch. 1, p. 3. https://doi.org/10.1021/bk-2010-1033.ch001

    Book  Google Scholar 

  170. D. Klemm, F. Kramer, S. Moritz, et al., Angew. Chem. Int. Ed. 50, 5438 (2011). https://doi.org/10.1002/anie.201001273

    Article  CAS  Google Scholar 

  171. N. S. V. Capanema, A. A. P. Mansur, A. C. de Jesus, et al., Int. J. Biol. Macromol. 106, 1218 (2018). https://doi.org/10.1016/j.ijbiomac.2017.08.124

    Article  CAS  Google Scholar 

  172. A. A. Oun and J.-W. Rhim, Carbohydr. Polym. 175, 712 (2017). https://doi.org/10.1016/j.carbpol.2017.08.052

    Article  CAS  Google Scholar 

  173. A. A. Oun and J.-W. Rhim, Int. J. Biol. Macromol. 152, 1038 (2020). https://doi.org/10.1016/j.ijbiomac.2019.10.191

    Article  CAS  Google Scholar 

  174. A. A. Oun and J.-W. Rhim, Carbohydr. Polym. 169, 467 (2017). https://doi.org/10.1016/j.carbpol.2017.04.042

    Article  CAS  Google Scholar 

  175. D. Hatanaka, K. Yamamoto, and J. Kadokawa, Int. J. Biol. Macromol. 69, 35 (2014). https://doi.org/10.1016/j.ijbiomac.2014.05.022

    Article  CAS  Google Scholar 

  176. J. Xu, Z. Zhou, J. Cai, and J. Tian, Int. J. Biol. Macromol. 156, 1183 (2019). https://doi.org/10.1016/j.ijbiomac.2019.11.154

    Article  CAS  Google Scholar 

  177. J. M. B. F. Diniz, M. H. Gil, and J. A. A. M. Castro, Wood Sci. Technol. 37, 489 (2004). https://doi.org/10.1007/s00226-003-0216-2

    Article  CAS  Google Scholar 

  178. E. Robles, A. M. Salaberria, R. Herrera, et al., Carbohydr. Polym. 144, 41 (2016). https://doi.org/10.1016/j.carbpol.2016.02.024

    Article  CAS  Google Scholar 

  179. F. G. Torres, S. Commeaux, and O. P. Troncoso, Starch 65, 543 (2013). https://doi.org/10.1002/star.201200259

    Article  CAS  Google Scholar 

  180. T. Hemamalini and V. R. Giri Dev, Int. J. Biol. Macromol. 106, 712 (2018). https://doi.org/10.1016/j.ijbiomac.2017.08.079

    Article  CAS  Google Scholar 

  181. J. N. BeMiller and R. L. Whistler, Starch: Chemistry and Technology (Academic, New York, 2009). https://doi.org/10.1016/S1082-0132(08)X0009-3

    Book  Google Scholar 

  182. Y. Huang, M. Yao, X. Zheng, et al., Biomacromolecules 16, 3499 (2015). https://doi.org/10.1021/acs.biomac.5b00928

    Article  CAS  Google Scholar 

  183. P. R. Chang, R. Jian, J. Yu, and X. Ma, Carbohydr. Polym. 80, 420 (2010). https://doi.org/10.1016/j.carbpol.2009.11.041

    Article  CAS  Google Scholar 

  184. K. G. Nair and A. Dufresne, Biomacromolecules 4, 657 (2003). https://doi.org/10.1021/bm020127b

    Article  CAS  Google Scholar 

  185. A. M. Salaberria, J. Labidi, and S. C. M. Fernandes, Chem. Eng. J. 256, 356 (2014). https://doi.org/10.1016/j.cej.2014.07.009

    Article  CAS  Google Scholar 

  186. Y. Qin, S. Zhang, and J. Yu, Carbohydr. Polym. 147, 372 (2016). https://doi.org/10.1016/j.carbpol.2016.03.095

    Article  CAS  Google Scholar 

  187. K. Varaprasad, T. Jayaramudu, V. Kanikireddy, et al., Carbohydr. Polym. 236, 116025 (2010). https://doi.org/10.1016/j.carbpol.2020.116025

    Article  CAS  Google Scholar 

  188. B. A. Aderibigbe and B. Buyana, Pharmaceutics 10, 42 (2018). https://doi.org/10.3390/pharmaceutics10020042

    Article  CAS  Google Scholar 

  189. D. Wang, R. Lv, X. Ma, et al., Food Hydrocoll. 83, 1 (2018). https://doi.org/10.1016/j.foodhyd.2018.04.021

    Article  CAS  Google Scholar 

  190. Y. Chen, H. Qiu, M. Dong, et al., Carbohydr. Polym. 206, 435 (2019). https://doi.org/10.1016/j.carbpol.2018.10.068

    Article  CAS  Google Scholar 

  191. A. Watthanaphanit, P. Supaphol, H. Tamura, et al., J. Appl. Polym. Sci. 110, 890 (2008). https://doi.org/10.1002/app.28634

    Article  CAS  Google Scholar 

  192. G. D. Prestwich, J. Control. Release 155, 193 (2011). https://doi.org/10.1016/j.jconrel.2011.04.007

    Article  CAS  Google Scholar 

  193. B. P. Toole, Nat. Rev. Cancer 4, 528 (2004). https://doi.org/10.1038/nrc1391

    Article  CAS  Google Scholar 

  194. X. Xu, A. K. Jha, D. A. Harrington, et al., Soft Matter 8, 3280 (2012). https://doi.org/10.1039/c2sm06463d

    Article  CAS  Google Scholar 

  195. M. Hiorth, T. Skøien, and S. A. Sande, Eur. J. Pharm. Biopharm. 75, 245 (2010). https://doi.org/10.1016/j.ejpb.2010.02.012

    Article  CAS  Google Scholar 

  196. P. Morganti, M. Palombo, G. Tishchenko, et al., Cosmetics 1, 140 (2014). https://doi.org/10.3390/cosmetics1030140

    Article  Google Scholar 

  197. M. Anraku, R. Tabuchi, and S. Ifuku, Int. J. Mol. Sci. 16, 24707 (2015). https://doi.org/10.3390/ijms161024707

    Article  CAS  Google Scholar 

  198. H. Moon, S. Choy, Y. Park, et al., Mar. Drugs 17, 318 (2019). https://doi.org/10.3390/md17060318

    Article  CAS  Google Scholar 

  199. Y. Duan, A. Freyburger, W. Kunz, and C. Zollfrank, Carbohydr. Polym. 192, 159 (2018). https://doi.org/10.1016/j.carbpol.2018.03.045

    Article  CAS  Google Scholar 

  200. A. C. Khorasani and S. A. Shojaosadati, Int. J. Biol. Macromol. 94, 131 (2017). https://doi.org/10.1016/j.ijbiomac.2016.10.011

    Article  CAS  Google Scholar 

  201. K. E. Eun, S. Y. Jung, S. J. Lee, et al., Int. J. Biol. Macromol. 38, 165 (2006). https://doi.org/10.1016/j.ijbiomac.2006.03.003

    Article  CAS  Google Scholar 

  202. J. Jin, P. Hassanzadeh, G. Perotto, et al., Adv. Mater. 25, 4482 (2013). https://doi.org/10.1002/adma.201301429

    Article  CAS  Google Scholar 

  203. C. R. Yoo, I.-S. Yeo, K. E. Park, et al., Int. J. Biol. Macromol. 42, 324 (2008). https://doi.org/10.1016/j.ijbiomac.2007.12.004

    Article  CAS  Google Scholar 

  204. M. G. Mehrabani, R. Karimian, R. Rakhshaei, et al., Biol. Macromol. 116, 966 (2018). https://doi.org/10.1016/j.ijbiomac.2018.05.102

    Article  CAS  Google Scholar 

  205. M. Azidi, A. Teimouri, and G. Mahranzadeh, RCS Adv. 6, 7048 (2016).

  206. N. Ashwinkumar, S. Maya, and R. Jayakumar, RSC Adv. 4, 49547 (2014). https://doi.org/10.1039/C4RA06578F

  207. Yu. S. Sotnikova, T. S. Demina, A. V. Istomin, et al., Fibre Chem. 49, 188 (2007). https://doi.org/10.1007/s10692-017-9867-x

    Article  CAS  Google Scholar 

  208. M. Carsi, M. J. Sanchis, and C. M. Gómez, Polymers (Basel) 11, 1083 (2019). https://doi.org/10.3390/polym11061083

    Article  CAS  Google Scholar 

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Funding

The first chapter of this work was financially supported by a Grant from the President of the Russian Federation (MK-3627.2019.3). The second and third chapters were written under financial support of the thematic plan Development of Process Solutions on the Preparation of New Medical Polymer and Hybrid Materials and Items Based on Bionic Design, Including Individual Implants (National Research Center Kurchatov Institute).

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  1. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 117393, Moscow, Russia

    O. I. Bogdanova, A. P. Istomina & S. N. Chvalun

  2. National Research Center Kurchatov Institute, 123182, Moscow, Russia

    O. I. Bogdanova, A. P. Istomina & S. N. Chvalun

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O.I. Bogdanova and A.P. Istomina each contributed equally to this article.

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Bogdanova, O.I., Istomina, A.P. & Chvalun, S.N. Composites Based on Chitin Nanoparticles and Biodegradable Polymers for Medical Use: Preparation and Properties. Nanotechnol Russia 16, 42–68 (2021). https://doi.org/10.1134/S2635167621010031

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