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Anti-inflammatory effects of sulphated polysaccharides extracted from brown marine algae

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Abstract

The modern theories on the anti-inflammatory effects of sulphated polysaccharides extracted from marine algae have been analyzed. It has been found that sulphated polysaccharides may play a double role in the immune response, as either an initiator or inhibitor of the inflammation process. State-of-the-art data and original results show that sulphated polysaccharides extracted from marine algae may be used as a basis for the immune-biological remedies of the new generation to cure allergies, autoimmune diseases, and other inflammations of different origins that are accompanied by the hyperproduction of inflammatory cytokines, nitrogen monoxide, and complements.

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References

  1. Bichucher, A.M. and Kozlov, L.V., Eksp. Klin. Farmakol., 2007, vol. 70, no. 6, p. 25.

    PubMed  CAS  Google Scholar 

  2. Bovin, N.V., Usov, A.I., and Ushakova, N.A., Vopr. Med. Khim., 1998, no. 2, p. 135.

  3. Bogomaz, T.A., Mechanisms of Regulation of Human Complement System by Some Natural Factors, Cand. Sci. (Med.) Dissertation, St. Petersburg: St. Peterb. Gos. Med. Univ. im. I.P. Pavlova, 2006.

    Google Scholar 

  4. Ermak, I.M., Davydova, V.N., and Aminin, D.L., Tikhookeansk. Med. Zh., 2009, no. 3, p. 40.

  5. Zaporozhets, T.S., Cellular and Molecular Mechanisms of Immunomodulatory Activity of Biopolymers from Marine Aquatic Organisms, Doctoral (Med.) Dissertation, Vladivostok: Vladivost. Gos. Med. Univ., 2006.

    Google Scholar 

  6. Zaporozhets, T.S. and Besednova, N.N., Immunoaktivnye biopolimery iz morskikh gidrobiontov (Immunoreactive Biopolymers from Marine Aquatic Organisms), Vladivostok: Izd. TINRO tsentra, 2007.

    Google Scholar 

  7. Imbs, T.I., Shevchenko, N.M., Sukhoverkhov, S.V., Semenova, T.L., Skriptsova, A.V., and Zvyagintseva, T.N., Khim. Prir. Soedin., 2009, no. 6, p. 661.

  8. Kiselev, S.A., Chicherin, D.S., and Kharitonov, D.V., Kachestvo zhizni (Quality of Life), Moscow: Meditsina, 2004, part 2.

    Google Scholar 

  9. Kuznetsova, T.A., Correction of Immunity and Hemostasis by Biopolymers from Marine Aquatic Organisms, Doctoral (Med.) Dissertation, Moscow: NIIVS im. I.I.Mechnikova, Ros. Akad. Med. Nauk, 2009.

    Google Scholar 

  10. Kuznetsova, T.A., Bull. Exp. Biol. Med., 2009, vol. 147, no. 1, p. 71.

    Article  Google Scholar 

  11. Kuznetsova, T.A., Zaporozhets, T.S., Besednova, N.N., Zvyagintseva, T.N., Shevchenko, N.M., Imbs, T.I., Mandrakova, N.V., and Mel’nikov, V.G., Vestn. DVO RAN, 2011, no. 2, p. 147.

  12. Nazarova, I.V., Effect of Polysaccharides from Seaweed and Herbs on the Complement System, Extended Abstract of Cand. Sci. (Med.) Dissertation, Vladivostok: Vladivost. Gos. Med. Univ., 1999.

    Google Scholar 

  13. Nazarova, I.V., Khotimchenko, Yu.S., Shevchenko, N.M., Gorbach, V.I., and Luk’yanov, P.A., Bull. Eksp. Biol. Med., 2001, vol. 131, no. 3, p. 290.

    Google Scholar 

  14. Tutel’yan, V.A., Mikronutrienty v pitanii zdorovogo i bol’nogo cheloveka (Micronutrients in the Diet of Healthy and Sick People), Moscow: Kolos, 2002.

    Google Scholar 

  15. Usov, A.I. and Bilan, M.I., Usp. Khim., 2009, no. 8, p. 846.

  16. Ustyuzhanina, N.E., in Tez. XVIII Mendeleevskogo s”ezda (Abstr. XVIII Mendeleev Congr.), Kazan, 2003, p. 45.

  17. Ushakova, N.A., Mikhailov, V.I., Mazurov, A.V., Berman, A.E., and Preobrazhenskaya, M.E., Vopr. Med. Khim., 1999, no. 5, p. 447.

  18. Back, H.-I., Kim, S.-Y., and Park, S.-H., FASEB J., 2011, vol. 25, no. 2, p. 35.

    Google Scholar 

  19. Blondin, C., Fischer, E., Boisson-Vidal, C., and Jozefonvicz, J., Mol. Immunol., 1994, vol. 31, no. 4, p. 247.

    Article  PubMed  CAS  Google Scholar 

  20. Cardoso, M.L., Xavier, C.A.C., Bezerra, M.B.E., Paiva, A.O.A., Carvalho, M.F.G., Benevides, M.M.B., Rocha, F.A.C., and Leite, E.L., Planta Med., 2010, vol. 76, no. 2, p. 113.

    Article  PubMed  CAS  Google Scholar 

  21. Chen, H.-C., Am. J. Gastroenterol., 2007, vol. 102, p. 725.

    Article  PubMed  Google Scholar 

  22. Chen, D., Wu, X.Z., and Wen, Z.Y., Panminerva Med., 2008, vol. 50, p. 177.

    PubMed  CAS  Google Scholar 

  23. Chung, H.-J., Jeun, J., Houng, S.-J., Jun, H.-J., Kweon, D.-K., and Lee, S.-J., Phytother. Res., 2010, vol. 24, p. 1078.

    PubMed  CAS  Google Scholar 

  24. Clement, M.J., Tissot, B., Chevolot, L., Adjadj, E., Du, Y., Curmi, P.A., and Daniel, R., Glycobiol. Adv. Access, 2010, vol. 3, p. 1225.

    Google Scholar 

  25. Cui, Y.-Q., Zhang, L.-J., and Zhang, T., Clin. Exp. Pharm. Physiol., 2010, vol. 37, p. 422.

    Article  CAS  Google Scholar 

  26. Cumashi, A., Ushakova, N.A., Preobrazhenskaya, M.E., D’Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G.E., Berman, A.E., Bilan, M.I., Usov, A.I., Ustyuzhanina, N.E., Grachev, A.A., Sanderson, C.J., Kelly, M., Rabinovich, G.A., Iacobelli, S., and Nifantiev, N.E., Glycobiology, 2007, vol. 17, p. 541.

    Article  PubMed  CAS  Google Scholar 

  27. D’Ayala, G.G., Malinconico, M., and Laurienco, P., Molecules, 2008, vol. 13, p. 2069.

    Article  PubMed  Google Scholar 

  28. Do, H., Pyo, S., and Sohn, E.N., J. Nutr. Biochem., 2010, vol. 21, p. 671.

    Article  PubMed  CAS  Google Scholar 

  29. Gibson, G.R. and Robertson, M.B., J. Nutr., 1995, vol. 125, no. 6, p. 1401.

    PubMed  CAS  Google Scholar 

  30. Granert, C., Raud, J., Xie, X., Lindquist, L., and Lindbom, L., J. Clin. Invest., 1994, vol. 93, p. 929.

    Article  PubMed  CAS  Google Scholar 

  31. Granert, C., Raud, J., Waage, A., and Lindquist, L., Inf. Immun., 1999, vol. 67, no. 5, p. 2071.

    CAS  Google Scholar 

  32. Honya, M., Mori, H., Akari, Y., and Nisizawa, K., Hydrobologia, 1999, vol. 398, p. 411.

    Article  Google Scholar 

  33. Hwang, P.A., Chien, S.-Y., Chan, Y.-L., Mei-Kuang, L., and Wu, C.-H., J. Agric. Food Chem., 2011, vol. 5, no. 2, p. 2062.

    Article  Google Scholar 

  34. Ishihara, K., Qyamada, C., Matsushima, R., Murata, M., and Muraoka, T., Boisci. Biotechnol. Biochem., 2005, vol. 69, no. 10, p. 1824.

    Article  CAS  Google Scholar 

  35. Iwamoto, K., Hiragun, T., Takahagi, S., Yanase, Y., Morioke, S., Mihara, S., Kameyoshi, Y., and Hide, M., Arch. Dermatol. Res., 2010, vol. 35, p. 86.

    Google Scholar 

  36. Jiao, G., Yu, G., Zhang, J., and Ewart, S., Mar. Drugs, 2011, vol. 9, p. 196.

    Article  PubMed  CAS  Google Scholar 

  37. Jimenez-Eskrig, A. and Sanchez-Muniz, F.J., Nutr. Res., 2000, vol. 20, p. 585.

    Article  Google Scholar 

  38. Jothisaraswathi, S., Babu, B., and Rengasamy, R., J. Appl. Phycol., 2006, vol. 18, p. 161.

    Article  CAS  Google Scholar 

  39. Kang, J.Y., Khan, M.N.A., Park, N.H., Cho, J.Y., Lee, M.C., Fujii, H., and Hong, Y.K., J. Ethnopharmacol., 2008, vol. 116, p. 187.

    Article  PubMed  CAS  Google Scholar 

  40. Kang, C.-H., Choi, Y.H., Choi, I.-W., Lee, J.-D., and Kim, G.-Y., Trop. J. Pharmac. Res., 2011, vol. 10, no. 2, p. 161.

    CAS  Google Scholar 

  41. Kimura, C., Koyama, T., Oike, M., and Ito, Y., Biochem. Biophys. Res. Commun., 2000, vol. 274, p. 736.

    Article  PubMed  CAS  Google Scholar 

  42. Kwak, K.W., Cho, K.S.L., Hahn, O.J., Lee, K.H., Lee, B.Y., Ko, J.J., and Chung, K.H., Korean J. Hematol., 2010, vol. 45, no. 1, p. 51.

    Article  PubMed  CAS  Google Scholar 

  43. Leonard, S.G., Sweeney, T., Bahar, P., Lynch, B.P., and O’Doherty, J.V., Brit. J. Nutrit., 2011, vol. 105, p. 549.

    Article  PubMed  CAS  Google Scholar 

  44. Ley, K., Linnemann, G., and Meinen, M., Stoolman, L.M., Gaethgens, P., Blood, 1993, vol. 81, p. 177.

    PubMed  CAS  Google Scholar 

  45. Leyro, J.M., Castro, R., Arranz, J.A., and Lamas, J., Int. Immunopharmacol., 2007, vol. 7, no. 7, p. 879.

    Article  Google Scholar 

  46. Loke, M.F., Lui, S.Y., and Nag, B.L., FEMS, 2007, vol. 50, no. 2, p. 231.

    CAS  Google Scholar 

  47. Lutau, N., Nilsson, J., Wadstrom, T., and Ljungh, A., Appl. Biochem. Biotechnol., 2011, vol. 164, no. 1, p. 1.

    Article  Google Scholar 

  48. Lynch, M.B., Sweeney, T., and Callan, J.J., J. Sci. Food Agricult., 2010, vol. 90, no. 3, p. 430.

    CAS  Google Scholar 

  49. Margret, R.J., Kumaresan, S., and Ravicumar, S., J. Environ. Biol., 2009, vol. 30, no. 5, p. 899.

    PubMed  Google Scholar 

  50. Maruyama, H., Tamauchi, H., Hashimoto, M., and Nakano, T., Int. Arch. Allergy Immunol., 2005, vol. 137, no. 4, p. 289.

    Article  PubMed  CAS  Google Scholar 

  51. Matsui, M.S., Muizzuddin, N., and Arad, S., Appl. Biochem. Biotechnol., 2003, vol. 104, no. 1, p. 13.

    Article  PubMed  CAS  Google Scholar 

  52. Matsumoto, S., Nagaoka, M., Hara, T., Kimura-Tagaki, I., Mistuyama, K., and Ueyama, S., Clin. Exp. Immunol., 2004, vol. 136, no. 3, p. 432.

    Article  PubMed  CAS  Google Scholar 

  53. Myers, S.P., O’Connor, J., Fitton, J.H., Brooks, L.O., Rolfe, M.I., Conneflan, M.I., Wohlmuth, H.C., and Morris C.A., Biologics, 2010, vol. 4, p. 33.

    PubMed  CAS  Google Scholar 

  54. Myers, S.P., O’Connor, J., Fitton, J.H., Brooks, L.O., and Morris, C.A., Biologics, 2011, vol. 5, p. 45.

    PubMed  Google Scholar 

  55. Mytar, B., Gawlika, M., Szatanek, R., Woloszin, M., Ruggiero, I., Piekarska, B., and Zembala, M., Inflamm. Res., 2004, vol. 53, no. 3, p. 100.

    Article  PubMed  CAS  Google Scholar 

  56. O’sullivan, L., Murphy, B., McLoughlin, P., Duggan, P., Lawlor, P.G., Hughes, H., and Gardiner, G.E., Mar. Drugs, 2010, vol. 8, p. 2038.

    Article  PubMed  Google Scholar 

  57. Park, S.-B., Chun, K.-R., Kim, J.K., Suk, K., Jung, Y.-M., and Lee, W.-H., Phytotherapy Res., 2010, vol. 24, p. 1384.

    Article  CAS  Google Scholar 

  58. Quanbin, Z., Zhien, L., Gefei, Z., and Niu, X., Chin. J. Oceanol. Limnol., 2003, vol. 21, no. 4, p. 324.

    Article  Google Scholar 

  59. Ramberg, J.E., Nelson, E.D., and Sinnot, R.A., Nutrit. J., 2010, vol. 9, p. 54.

    Article  Google Scholar 

  60. Rioux, L.E., Turgeon, S.L., and Beaulieu, M., Phytochemistry, 2010, vol. 71, p. 1586.

    Article  PubMed  CAS  Google Scholar 

  61. Rodzinski, E., Jones, T., Burnette, W.N., Burroughs, M., and Tuomanen, E.I., J. Infect. D, 1993, vol. 168, p. 1422.

    Article  Google Scholar 

  62. Sato, S. and Tanbara, K., Bull. Japan. Soc. Sci. Fis., vol. 46, no. 6, p. 749.

  63. Senni, K., Gueniche, F., Foucault-Bertaud, A., Igondjo-Tchen, S., and Fioretti, F., Arch. Biochem. Biophys., 2006, vol. 445, no. 1, p. 56.

    Article  PubMed  CAS  Google Scholar 

  64. Shibata, H., Imuro, M., and Uchiya, N., Helicobacter, 2003, vol. 8, no. 1, p. 59.

    Article  PubMed  CAS  Google Scholar 

  65. Shimaoka, M., Ikeda, M., Iida, M., Taenaka, N., Yoshiya, I., and Honda, T., Am. J. Respir. Crit. Care Med., 1996, vol. 153, no. 1, p. 307.

    PubMed  CAS  Google Scholar 

  66. Siqueira, R.C.L., de Alencar, D., Wylane, M.M., Pereira, M.G., Cavada, B.S., Sampaio, A.H., Farias, W.R.L., and Assrey, A.M., Pharm. Biol., 2011, vol. 49, no. 2, p. 167.

    Article  PubMed  CAS  Google Scholar 

  67. Sweeney, T., Dillon, S., Fanning, J., Mannion, C., Leonard, F., and O’Doherty, J.V., Animal, 2011, vol. 165, no. 1, p. 85.

    CAS  Google Scholar 

  68. Teixeira, M.M. and Hellewell, P., Brit. J. Pharmacol., 1997, vol. 120, p. 1059.

    Article  CAS  Google Scholar 

  69. Tissot, B., Montdargent, B., Chevolot, L., Varenne, A., Descroix, S., Gareil, P., and Daniel, R., Biochem. Biophys. Acta, 2003, vol. 1651, nos. 1–2, p. 5.

    PubMed  CAS  Google Scholar 

  70. Tissot, B., Daniel, R., and Place, Ch., Eur. J. Biochem., 2003, vol. 270, no. 23, p. 4714.

    Article  PubMed  CAS  Google Scholar 

  71. Varki, A., Proc. Natl. Acad. Sci. USA, 1994, vol. 91, p. 7390.

    Article  PubMed  CAS  Google Scholar 

  72. Wang, Y., Han, F., Hu, B., Li, J.B., and Yu, W.G., Nut. Res., 2006, vol. 26, p. 597.

    Article  CAS  Google Scholar 

  73. Zen, K., Liu, Y., Cairo, Y.D., and Parkos, C.A., J. Immunol., 2002, vol. 169, p. 5270.

    PubMed  Google Scholar 

  74. Zhang, X.W., Liu, Q., and Thorlacius, H., Scand. J. Gastroenterol., 2001, vol. 36, no. 3, p. 270.

    Article  PubMed  CAS  Google Scholar 

  75. Zvyagintseva, T.N., Shevchenko, N.M., Nazarova, I.O., Scobun, A.S., Luc’jano, P.A., and Elyakova L.A., Comp. Biochem. Physiol., 2000, vol. 26, p. 209.

    Google Scholar 

  76. Yanase, Y., Hiragun, T., Uchida, K., Ishii, K., Oomizu, S., Suzuki, H., Mihara, S., Iwamoto, K., Matsuo, H., Onishi, N., and Hide, M., Biochem. Biophys. Res. Commun., 2009, vol. 387, p. 435.

    Article  PubMed  CAS  Google Scholar 

  77. Yang, J.W., Yoon, S.Y., Oh, S.J., Kim, S.K., and Kang, K.W., Biochem. Biophys. Res. Commun., 2006, vol. 346, no. 1, p. 345.

    Article  PubMed  CAS  Google Scholar 

  78. Yarnell, E.N.D. and Abascal, K.B.S., Altern. Complement. Ther., 2008, vol. 14, no. 3, p. 139.

    Article  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Epidemiology and Microbiology Siberian Branch, Russian Academy of Medical Sciences, Vladivostok, Russia

    N. N. Besednova, T. S. Zaporozhets, I. D. Makarenkova, T. A. Kuznetsova, S. P. Kryzhanoskii, T. N. Zvyagintseva & V. G. Mel’nikov

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  1. N. N. Besednova
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  2. T. S. Zaporozhets
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  3. I. D. Makarenkova
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Original Russian Text © N.N. Besednova, T.S. Zaporozhets, I.D. Makarenkova, T.A. Kuznetsova, S.P. Kryzhanoskii, T.N. Zvyagintseva, V.G. Mel’nikov, 2012, published in Uspekhi Sovremennoi Biologii, 2012, Vol. 132, No. 3, pp. 312–320.

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Besednova, N.N., Zaporozhets, T.S., Makarenkova, I.D. et al. Anti-inflammatory effects of sulphated polysaccharides extracted from brown marine algae. Biol Bull Rev 2, 525–532 (2012). https://doi.org/10.1134/S2079086412060023

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