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Endothelial signaling molecules in the development of age-associated diseases

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Abstract

Data on endothelial signaling molecules involved in homeostasis regulation and development of age-associated disorders are summarized. Regulation of the endothelium function is implemented by a system of signaling molecules: NO, NO synthase, prostacyclin, thrombomodulin, thromboxane, antithrombin, endothelins, fibronectin, von Willebrand factor, etc. Changes in their synthesis can cause arterial hypertension, atherosclerosis, ischemic heart disease, myocardial infarction, and other age-related disorders. Study of the molecular mechanisms mediating endothelial functioning is essential for developing new methods of diagnostics and a treatment for age-associated cardiovascular diseases.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, pr. Dinamo 3, St. Petersburg, 197110, Russia

    K. L. Kozlov, V. M. Soldatov & E. V. Sedov

  2. Pskov Oblast Hospital, ul. Malyasova 2, Pskov, 180007, Russia

    V. M. Soldatov

  3. Petrovskii Russian National Center of Surgery, Russian Academy of Medical Sciences, Abrikosovskii per. 2, Moscow, 119991, Russia

    E. M. Paltseva

  4. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleyevskaya liniya 3, St. Petersburg, 199034, Russia

    V. O. Polyakova

  5. St. Petersburg State Polytechnical University, ul. Polytekhnicheskaya 29, St. Petersburg, 195251, Russia

    N. S. Linkova

Authors
  1. K. L. Kozlov
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  2. V. M. Soldatov
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  3. E. M. Paltseva
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  4. E. V. Sedov
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  5. V. O. Polyakova
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  6. N. S. Linkova
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Correspondence to N. S. Linkova.

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Original Russian Text © K.L. Kozlov, V.M. Soldatov, E.M. Paltseva, E.V. Sedov, V.O. Polyakova, N.S. Linkova, 2015, published in Uspekhi Gerontologii, 2015, Vol. 28, No. 1, pp. 29–36.

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Kozlov, K.L., Soldatov, V.M., Paltseva, E.M. et al. Endothelial signaling molecules in the development of age-associated diseases. Adv Gerontol 5, 121–127 (2015). https://doi.org/10.1134/S2079057015020071

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