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The ovary: Ontogenesis and ageing

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Abstract

Issues related to the neuroendocrine mechanisms responsible for the development and ageing of the ovary, as a reproductive organ participating in sustaining homeostasis on the level of the whole body, are discussed in the review. Also given are the latest data on the role of immune cells of ovaries in the mechanisms of their ageing-related involution, which opens new prospects for studying ovarian ageing in the aspect of interlink between the ovary and the immune system.

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References

  1. Balan, V.E., Vikhlyaeva, E.M., Zaidieva, Ya.Z., et al., Menopauzal’nyi sindrom (klinika, diagnostika, profilaktika i zamestitel’naya gormonal’naya terapiya) (Menopausal Syndrome (Clinic, Diagnostic, Prophylactics and Hormonal Replacement Therapy), Moscow: Meditsina, 1996.

    Google Scholar 

  2. Dil’man, V.M., Bol’shie biologicheskie chasy (vvedenie v integral’nuyu meditsinu) (The Big Biological Clocks (Introduction to Integral Medicine)), Moscow: Znanie, 1982.

    Google Scholar 

  3. Khavinson, V.Kh., Kvetnoi, I.M., Inel’, I.E., and Mar’yanovich, A.T., Age Evolution of Organs and Tissues, Usp. Fiziol. Nauk, 2003, vol. 34, no. 1, pp. 79–92.

    Google Scholar 

  4. Khavinson, V.Kh., Kvetnoi, I.M., Yuzhakov, V.V., et al., Peptidergicheskaya regulyatsiya gomeostaza (Peptide-Ergic Regulation of Homeostasis), St. Petersburg: Nauka, 2003.

    Google Scholar 

  5. Anisimov, V.N. and Khavinson, V.Kh., Peptide Bioregulation of Aging: Results and Prospects, Biogerontology, 2010, vol. 11, pp. 139–149.

    Article  PubMed  CAS  Google Scholar 

  6. Brodowska, A., Laszczyn-ska, M., Starczewski, A., et al., Immunohistochemical Analysis of Steroid Receptors in Ovaries of Postmenopausal Women—Effects of Aging and Hormone Status, Histol. Histopathol., 2010, vol. 25, no. 8, pp. 1009–1016.

    PubMed  CAS  Google Scholar 

  7. Broekmans, F.J., Soules, M.R., and Fauser, B.C., Ovarian Aging: Mechanisms and Clinical Consequences, Endocr. Rev., 2009, vol. 30, no. 5, pp. 465–493.

    Article  PubMed  CAS  Google Scholar 

  8. Buyuk, E., Nejat, E., and Neal-Perry, G., Determinants of Female Reproductive Senescence: Differential Roles for the Ovary and the Neuroendocrine Axis, Seminars Reprod. Med., 2010, vol. 28, no. 5, pp. 370–379.

    Article  CAS  Google Scholar 

  9. Engelman, F., Barron, A., Urbannski, H., et al., Accelerated Immune Senescence and Reduced Response to Vaccination in Ovariectomized Female Rhesus Macaques, Amer. J. Primat., 2010, vol. 71, no. 10, pp. 785–792.

    Google Scholar 

  10. Figueira Rde, C., Braga, D.P., Nichi, M., et al., Poor Ovarian Response in Patients Younger than 35 Years: Is It also a Qualitative Decline in Ovarian, Hum. Fertil. (Camb.), 2009, vol. 12, no. 3, pp. 160–165.

    Article  Google Scholar 

  11. Hurwitz, J.M., Jindal, S., Greensied, K., et al., Reproductive Aging Is Associated with Altered Gene Expression in Human Luteinized Granulose Cells, Reprod. Sci., 2010, vol. 17, no. 1, pp. 56–67.

    Article  PubMed  CAS  Google Scholar 

  12. Huser, M., Crha, I., Záková, J., and Ventuba, P., Process of Women’s Reproductive Ageing—Causes, Evaluation and Possible Clinical Usage, Čsl. Gynek., 2010, vol. 75, no. 4, pp. 353–358.

    Google Scholar 

  13. Mason, J.B., Cargill, S.L., Anderson, G.B., and Carey, J.R., Ovarian Status Influenced the Rate of Body-Weight Change but not the Total Amount of Body-Weight Gained or Lost in Female CBA/J Mice, Exp. Geront., 2010, vol. 45, no. 6, pp. 435–441.

    Article  Google Scholar 

  14. Miao, Y.L., Kikuchi, K., Sun, Q.Y., and Schatten, H., Oocyte Aging: Cellular and Molecular Changes, Developmental Potential and Reversal Possibility, Hum. Reprod. Update, 2009, vol. 15, no. 5, pp. 573–585.

    Article  PubMed  Google Scholar 

  15. Nejat, E.J. and Chervenak, J.L., The Continuum of Ovarian Aging and Clinicopathologies Associated with the Menopausal Transition, Maturitas, 2010, vol. 66, no. 2, pp. 187–190.

    Article  PubMed  Google Scholar 

  16. Nolen, R.S., Rottseller Study Links Ovaries with Exceptional Longevity, J. Amer. Vet. Med. Ass., 2010, vol. 236, no. 5, p. 496.

    PubMed  Google Scholar 

  17. Pepling, M.E., Sundman, E.A., Patterson, N.L., et al., Differences in Oocyte Development and Estradiol Sensitivity among Mouse Strains, Reproduction, 2010, vol. 139, no. 2, pp. 349–357.

    Article  PubMed  CAS  Google Scholar 

  18. Rodgers, R.J. and Irving-Rodgers, H.F., Morphological Classification of Bovine Ovarian Follicles, Reproduction, 2010, vol. 139, no. 2, pp. 309–318.

    Article  PubMed  CAS  Google Scholar 

  19. Roland, A.V., Nunemaker, C.S., Keller, S.R., and Moenter, S.V., Prenatal Androgen Exposure Programs Metabolic Dysfunction in Female Mice, J. Endocr., 2010, vol. 207, no. 2, pp. 213–223.

    Article  PubMed  CAS  Google Scholar 

  20. Tatone, C., Carbone, M.C., Campanella, G., et al., Female Reproductive Dysfunction during Ageing: Role of Methylglyoxal in the Formation of Advanced Glycation Endproducts in Ovaries of Reproductively-Aged Mice, J. Boil. Regul. Homeost. Agents, 2010, vol. 24, no. 1, pp. 63–72.

    CAS  Google Scholar 

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Correspondence to E. A. Morozova.

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Original Russian Text © E.A. Morozova, N.S. Lin’kova, V.O. Polyakova, I.M. Kvetnoi, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 3, pp. 393–396.

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Morozova, E.A., Lin’kova, N.S., Polyakova, V.O. et al. The ovary: Ontogenesis and ageing. Adv Gerontol 2, 130–133 (2012). https://doi.org/10.1134/S2079057012020117

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