Skip to main content
SpringerLink
Log in

Influence of peptides from pineal gland on thymus function with aging

  • Published:
Advances in Gerontology Aims and scope Submit manuscript

Abstract

This review considers the mutual influence of the thymus and pineal gland on each other during their involution. Research data on the influence of thymus peptides on the pineal gland and of pineal peptides on the thymus is summarized. An analysis of the data showed that pineal peptides (epithalamin, epitalon) had more a effective geroprotective effect on thymus involution in comparison with the geroprotective effect of thymic peptides (thymalin, thymogen) on the involution of the pineal gland. The key mechanisms of pineal peptides’ effect on thymus dystrophy is immunoendocrine cooperation, which is realized via transcription activation of various proteins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Anisimov, V.N. and Khavinson, V.Kh., Pineal Peptides as Modulators of Aging, in Aging Interventions and Therapies, Rattan, S.I.S., Ed., World Scientific, 2005, pp. 127–146.

  2. Anisimov, V.N., Khavinson, V.Kh., Morozov, V.G., A Role of Peptides of Epiphysis in Regulation of Homeostasis: Twenty Years Experience of Investigations, Uspekhi Sovrem. Biol., 1993, vol. 113,issue 6, pp. 752–762.

    CAS  Google Scholar 

  3. El-Sokkary, G.H., Reiter, R.J., and Abdel-Ghaffar, S.K., Melatonin Supplementation Restores Cellular Proliferation and DNA Synthesis in the Splenic and Thymic Lymphocytes of Old Rats, Neuroendocr. Lett., 2003, vol. 24, nos. 3–4, pp. 215–223.

    CAS  Google Scholar 

  4. Fabris, N., Vocchegiani, E., and Provinciali, M., Plasticity of Neuroendocrine-Thymus Interaction During Aging, Exp. Geront., 1997, vol. 32, nos. 4–5, pp. 415–429.

    Article  CAS  Google Scholar 

  5. Guerrero, J.M. and Reiter, R.J., Melatonin-Immune System Relationships, Curr. Topics Med. Chemistry, 2002, vol. 2, no. 2, pp. 167–179.

    Article  CAS  Google Scholar 

  6. Khavinson, V.Kh. Peptides and Aging, Neuroendocr. Lett. (Special Issue), 2002.

  7. Khavinson, V.Kh., Peptidnaya regulyatsiya stareniya (Peptide Regulation of Senescence), St.-Petersburg: Nauka, 2009.

    Google Scholar 

  8. Khavinson, V.Kh. and Morozov, V.G., Peptidy epifiza i timusa v regulyatsii stareniya (Peptides of Epiphysis and Thymus in Senescence Regulation), St.-Petersburg: Foliant, 2001.

    Google Scholar 

  9. Khavinson, V.Kh. and Malinin, V.V., The Mechanisms of Geroprotective Activity of Peptides, Bull. Eksper. Biol., 2002, vol. 133, no. 1, pp. 4–10.

    Google Scholar 

  10. Khavinson, V.Kh. and Anisimov, V.N., Peptidnye bioregulyatory i starenie (Peptide Bioregulators and Senescence), St.-Petersburg: Nauka, 2003.

    Google Scholar 

  11. Khavinson, V.Kh., Kvetnoi, I.M., Yuzhakov, V.V., et al., Peptidergicheskaya regulyatsiya gomeostasa (Peptidergic Regulation of Homeostasis), St.-Petersburg: Nauka, 2003.

    Google Scholar 

  12. Khavinson, V. and Morozov, V., Peptides of Pineal Gland and Thymus Prolong Human Life, Neuroendocr. Lett., 2003, vol. 24, nos. 3–4, pp. 233–240.

    CAS  Google Scholar 

  13. Khavinson, V.Kh. and Anisimov, V.N., 35-Year Experience of Investigation of Senescence Peptide Regulation, Uspekhi Gerontol., 2009, vol. 7, no. 1, pp. 11–23.

    Google Scholar 

  14. Kvetnaya, T.V., Knyaz’kin, I.V., and Kvetnoi, I.M., Melatonin — neiroimmunoendokrinnyi marker vozrastnoi patologii (Melatonin — Neuro-immuno-endocrinous Marker of Age Pathology) St.-Petersburg: Dean, 2005.

    Google Scholar 

  15. Kvetnoi, I.M., Yarilin, A.A., Polyakova, V.O., and Knyaz’kin, I.V., Neiroimmunoendokrinologiya timusa (Thymus Neuro-immuno-endocrinology), St.-Petersburg: Dean, 2005.

    Google Scholar 

  16. Knyaz’kin, I.V., Pineal Gland and Extrapineal Sources of Melatonin in Visceral Organs at Natural Human Aging, Uspekhi Gerontol., 2008, vol. 21, no. 1, pp. 83–85.

    Google Scholar 

  17. Korkushko, O.V., Lapin, B.A., Goncharova, N.D., et al., Normalizing Influence of Peptides of Epiphysis on Daily Rhythm of Melatonin in Old Monkeys and People of Elderly Age, Uspekhi Gerontol., 2007, vol. 20, no. 1, pp. 74–85.

    CAS  Google Scholar 

  18. Labunets, I.F., Influence of Melatonin on Biorhythms of Functional Status of Thymus, Immune System and Adrenal Glands Cortex in Elderly People, Probl. Stareniya i Dolgoletiya, 2005, vol. 14, no. 4, pp. 313–322.

    CAS  Google Scholar 

  19. Labunets, I.F., Influence of Biological Active Factors of Thymus on Melatonin-Forming Function of Epiphysis in Different Age Animals: Possible Mechanisms, Uspekhi Gerontol., 2007, vol. 20, no. 1, pp. 86–91.

    CAS  Google Scholar 

  20. Morozov, V.G. and Khavinson, V.Kh., Extraction of Polypeptides Regulating the Processes of Intercellular Cooperation in Immune System from Marrow, Lymphocytes and Thymus, Dokl. AN SSSR, 1981, vol. 261, no. 1, pp. 235–239.

    CAS  Google Scholar 

  21. Pal’tsev, M.A. and Kvetnoi, I.M., Rukovodstvo po neiroimmunoendokrinologii (Manual on Neuroimmuno-endocrinology), Moscow: Meditsina, 2006.

    Google Scholar 

  22. Pirozhkov, S.I., Safarove G.Z., Senescence Tendencies of Inhabitants of Russia and Ukraine, Uspekhi Gerontol., 2000, issue 7, pp. 14–21.

  23. Polyakova, V.O. and Kvetnoi, I.M., Structural-Functional Conformity of Pineal Gland and Thymus: A Role and Value of Neuro-immuno-endocrinous Regulation of Homeostasis, Neuroimmunology, 2009, vol. 7, no. 1, pp. 85–86.

    Google Scholar 

  24. Safarova, G.L., Demography of Senescence: Present Status and Priorities of Investigations, Uspekhi Gerontol., 2009, vol. 22, no. 1, pp. 49–59.

    CAS  Google Scholar 

  25. Tian, Y.M., Li, P.P., and Jiang, X.F., Rejuvenation of Degenerative Thymus by Oral Melatonin Administration and the Antagonistic Action of Melatonin Against Hydroxyl Radical-Induced Apoptosis of Cultured Thymocytes in Mice, J. Pineal Res., 2001, vol. 31, no. 3, pp. 214–221.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, Northwest Branch of the Russian Academy of Medical Sciences, prosp. Dinamo 3, St. Petersburg, 197110, Russia

    N. S. Linkova, V. O. Polyakova, A. V. Trofimov, N. N. Sevostianova & I. M. Kvetnoy

Authors
  1. N. S. Linkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. O. Polyakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Trofimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. N. Sevostianova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. M. Kvetnoy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. M. Kvetnoy.

Additional information

Original Russian Text © N.S. Linkova, V.O. Polyakova, A.V. Trofimov, N.N. Sevostianova, I.M. Kvetnoy, 2010, published in Uspekhi Gerontologii, 2010, Vol. 23, No. 4, pp. 543–546.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Linkova, N.S., Polyakova, V.O., Trofimov, A.V. et al. Influence of peptides from pineal gland on thymus function with aging. Adv Gerontol 1, 240–243 (2011). https://doi.org/10.1134/S2079057011030076

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057011030076

Keywords

Search

Navigation