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Porphyrin-fullerene nanoparticles for treatment of hypoxic cardiopathies

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Abstract

In this study, low-toxic fullerene-based nanocationite particles (adducts of porphyrin with cyclohexyl fullerene C60) designated for targeted delivery of the paramagnetic stable magnesium isotope to heart muscle is reported for the first time; these particles exhibit a sharp clinical effect of 80% recovery from tissue hypoxia in less than 24 h after a single injection (0.03–0.1 LD50). This therapy is based on a novel principle: 25Mg2+ released by nanoparticles due to the magnetic isotopic effect selectively stimulates the additional production of ATP in oxygen-depleted cells. These cationite “smart nanoparticles,” which possess a membranotropic effect, release hyperactivating paramagnetic cations only in response to a metabolic acidic shift. The final positive changes in the energy metabolism of heart muscle cells are capable of helping to prevent and/or treat local hypoxia of heart muscle, and therefore, protect heart muscle from serious damage in a wide variety of clinical cases of hypoxia, including cardiotoxic side effects of doxorubicin and 1-methylnicotineamide. Both the pharmacokinetics and pharmacodynamics of the proposed drug allow safe and efficient administration in single-and multi-injection (acute and chronic) therapeutic schemes.

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Author information

Authors and Affiliations

  1. Pharmaceutical Faculty, Sechenov Medical Academy, Moscow, Russia

    N. Amirshahi & R. N. Alyautdin

  2. Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran

    S. Sarkar & S. M. Rezayat

  3. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    M. A. Orlova & I. V. Trushkov

  4. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. L. Buchachenko & D. A. Kuznetsov

Authors
  1. N. Amirshahi
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  2. R. N. Alyautdin
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  3. S. Sarkar
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  4. S. M. Rezayat
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  5. M. A. Orlova
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  6. I. V. Trushkov
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  7. A. L. Buchachenko
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  8. D. A. Kuznetsov
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Correspondence to N. Amirshahi.

Additional information

Original Russian Text © N. Amirshahi, R.N. Alyautdin, S. Sarkar, S.M. Rezayat, M.A. Orlova, I.V. Trushkov, A.L. Buchachenko, D.A. Kuznetsov, 2008, published in Rossiiskie nanotekhnologii, 2008, Vol. 3, Nos. 9–10.

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Amirshahi, N., Alyautdin, R.N., Sarkar, S. et al. Porphyrin-fullerene nanoparticles for treatment of hypoxic cardiopathies. Nanotechnol Russia 3, 611–621 (2008). https://doi.org/10.1134/S1995078008090115

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