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Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse—Mechanisms of Functioning and Control Methods

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

In the framework of the kinetic model, the functioning of the cholinergic synapse is considered. The results of mathematical modeling of changes in the level of acetylcholine, induced pH impulse, the influence of the frequency of impulse transmission and inhibition of acetylcholinesterase are presented. Physicochemical explanation for a number of important physiological phenomena, such as neuromuscular paralysis, the molecular mechanism of neurological memory, and actions of nerve poisons and toxins, is given.

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ACKNOWLEDGMENTS

This work was supported by the Russian Science Foundation (project no. 18-13-00030).

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Authors and Affiliations

  1. Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intellegence, Moscow State University, Moscow, Russia

    S. D. Varfolomeev

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    V. I. Bykov & S. B. Tsybenova

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  1. S. D. Varfolomeev
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  2. V. I. Bykov
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  3. S. B. Tsybenova
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Correspondence to V. I. Bykov.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Varfolomeev, S.D., Bykov, V.I. & Tsybenova, S.B. Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse—Mechanisms of Functioning and Control Methods. Dokl Biochem Biophys 492, 147–151 (2020). https://doi.org/10.1134/S1607672920030126

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  • DOI: https://doi.org/10.1134/S1607672920030126

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