Abstract
It was found that the use of a new strain-producer Escherichia coli, expressing the heme receptor ChuA, enables obtaining a hemin-containing modular nanotransporter (MNT) for drug delivery into the nuclei of target cells. The hemin-containing MNT becomes stabilized, which leads to an increase in its thermal stability and prevents aggregation of this protein.
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ACKNOWLEDGMENTS
The experiments were performed using the equipment of the Core Facility of the Institute of Gene Biology, Russian Academy of Sciences.
Funding
Study performed by a grant from the Russian Science Foundation (project no. 17-14-01304).
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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by M. Batrukova
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Khramtsov, Y.V., Ulasov, A.V., Rosenkranz, A.A. et al. Stabilization of Modular Nanotransporters by Embedding Hemin in Them in a New Strain with Heme Receptor Expression. Dokl Biochem Biophys 490, 47–49 (2020). https://doi.org/10.1134/S1607672920010093
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DOI: https://doi.org/10.1134/S1607672920010093