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Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract—Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

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Funding

This work was supported by the Russian Science Foundation (project no. 19-15-00093).

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    N. N. Dygalo, D. A. Lanshakov, N. P. Komysheva, U. S. Drozd, E. V. Shaburova, E. V. Sukhareva & G. T. Shishkina

  2. Novosibirsk State University, Novosibirsk, Russia

    N. N. Dygalo, U. S. Drozd, E. V. Shaburova & E. V. Sukhareva

Authors
  1. N. N. Dygalo
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  2. D. A. Lanshakov
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  3. N. P. Komysheva
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  4. U. S. Drozd
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  5. E. V. Shaburova
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  6. E. V. Sukhareva
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  7. G. T. Shishkina
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Corresponding author

Correspondence to N. N. Dygalo.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. Experiments on animals were in compliance with the rules of humane treatment of experimental animals (order no. 755 of the USSR Ministry of Health dated August 12, 1977).

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Translated by M. Batrukova

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Dygalo, N.N., Lanshakov, D.A., Komysheva, N.P. et al. Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety. Dokl Biochem Biophys 490, 16–18 (2020). https://doi.org/10.1134/S1607672920010056

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  • DOI: https://doi.org/10.1134/S1607672920010056

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