Skip to main content
SpringerLink
Log in

The Generation of the Human mAb RabD4 Specific to the Rabies Virus Glycoprotein and Characterization Thereof

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation of human peripheral B cells produced by immunized donor. The human mAb RabD4 showed a high antigen-binding activity and virus-neutralizing activity in the FAVN test with the CVS-11 rabies virus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Fisher, C.R., Streicker, D.G., and Schnell, M.J., Nat. Rev. Microbiol., 2018, vol. 16, pp. 241–255.

    Article  CAS  PubMed  Google Scholar 

  2. Kohler, G. and Milstein, C., Nature, 1975, vol. 256, pp. 495–497.

    Article  CAS  PubMed  Google Scholar 

  3. Ilina, E.N., Solopova, O.N., Balabashin, D.S., Larina, M.V., Aliev, T.K., Grebennikova, T.V., Losich, M.A., Zaykova, O.N., Sveshnikov, P.G., Dolgikh, D.A., and Kirpichnikov, M.P., Russ. J. Bioorg. Chem., 2019, vol. 45, no. 1, pp. 1–11.

  4. de Kruif, J., Bakker, A.B., Marissen, W.E., Kramer, R.A., Throsby, M., Rupprecht, C.E., and Goudsmit, J., Annu. Rev. Med., 2007, vol. 58, pp. 359–368.

    Article  CAS  PubMed  Google Scholar 

  5. Laemmli, U.K., Nature, 1970, vol. 227, pp. 680–685.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Moscow State University, 119991, Moscow, Russia

    E. N. Ilina, T. K. Aliev, D. A. Dolgikh &  M. P. Kirpichnikov

  2. All-Russia Research Center of Molecular Diagnostics and Therapy, 117149, Moscow, Russia

    E. V. Solopova, N. E. Varlamov & P. G. Sveshnikov

  3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    M. V. Larina, D. S. Balabashin, D. A. Dolgikh &  M. P. Kirpichnikov

Authors
  1. E. N. Ilina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Solopova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. K. Aliev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Larina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. S. Balabashin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. E. Varlamov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D. A. Dolgikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. G. Sveshnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. P. Kirpichnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. N. Ilina.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ilina, E.N., Solopova, E.V., Aliev, T.K. et al. The Generation of the Human mAb RabD4 Specific to the Rabies Virus Glycoprotein and Characterization Thereof. Dokl Biochem Biophys 485, 126–128 (2019). https://doi.org/10.1134/S1607672919020133

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672919020133

Search

Navigation