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Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. For this purpose, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of actomyosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain and does not depend on the processes of cross-bridges formation.

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References

  1. Canon, F. and Goubel, E., Pflugers Arch., 1995, vol. 429, pp. 332–337

    Article  PubMed  CAS  Google Scholar 

  2. McDonald, K.S. and Fitts, R.H., J. Appl. Physiol., 1995, vol. 79, pp. 1796–1802

    Article  PubMed  CAS  Google Scholar 

  3. Toursel, T., Stevens, L., Granzier, H., and Mounier, Y., J. Appl. Physiol., 2002, vol. 92, pp. 1465–1472

    Article  PubMed  Google Scholar 

  4. Ogneva, I., J. Appl. Physiol., 2010, vol. 109, pp. 1702–1709

    Article  PubMed  CAS  Google Scholar 

  5. Ogneva, I.V., Ponomareva, E.V., Altaeva, E.G., Fokina, N.M., Kurushin, V.A., Kozlovskaya, I.B., and Shenkman, B.S., Acta Astronaut., 2011, vol. 68, pp. 1478–1485

    Article  Google Scholar 

  6. Salazar, J.J., Michele, D.E., and Brooks, S.V., J. Appl. Physiol., 2011, vol. 108, pp. 120–127

    Article  CAS  Google Scholar 

  7. Riley, D.A., Bain, J.L.W., Romatowski, J.G., and Fitts, R.H., Am. J. Physiol. Cell. Physiol., 2005, vol. 288, pp. C360–C365.

    Article  PubMed  CAS  Google Scholar 

  8. Shenkman, B.S., Belova, S.P., Lomonosova, Y.N., Kostrominova, T.Y., and Nemirovskaya, T.L., Arch. Biochem. Biophys., 2015, vol. 584, pp. 36–41

    Article  PubMed  CAS  Google Scholar 

  9. Kovacs, M., Toth, J., Hetenyi, C., Malnasi-Csizmadia, A., and Sellers, J.R., J. Biol. Chem., 2004, vol. 279, no. 34, pp. 35557–35563

    Article  PubMed  CAS  Google Scholar 

  10. Granzier, H.L. and Wang, K., Biophys. J., 1993, vol. 65, pp. 2141–2159

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Campbell, K.S. and Lakie, M., J. Physiol., 1998, vol. 510, pp. 941–962

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Whitehead, N.P., Gregory, J.E., Morgan, D.L., and Proske, U., J. Physiol., 2001, vol. 536, pp. 893–903

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Irving, T., Wu, Y., Bekyarova, T., Farman, G.P., Fukuda, N., and Granzier, H., Biophys. J., 2011, vol. 100, pp. 1499–1508

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Muhle-Goll, C., Habeck, M., Cazorla, O., Nilges, M., Labeit, S., and Granzier, H., J. Mol. Biol., 2001, vol. 313, pp. 431–447

    Article  PubMed  CAS  Google Scholar 

  15. Grison, M., Merkel, U., Kostan, J., Djinović-Carugo, K., and Rief, M., Proc. Natl. Acad. Sci. U. S. A., 2017, vol. 114, pp. 1015–1020

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    I. O. Petrova, S. A. Tyganov, T. M. Mirzoev, I. B. Kozlovskaya & B. S. Shenkman

  2. Institute of Mechanics, Moscow State University, Moscow, 119192, Russia

    A. K. Tsaturyan

Authors
  1. I. O. Petrova
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  2. S. A. Tyganov
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  3. T. M. Mirzoev
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  4. A. K. Tsaturyan
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  5. I. B. Kozlovskaya
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  6. B. S. Shenkman
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Corresponding author

Correspondence to B. S. Shenkman.

Additional information

Original Russian Text © I.O. Petrova, S.A. Tyganov, T.M. Mirzoev, A.K. Tsaturyan, I.B. Kozlovskaya, B.S. Shenkman, 2018, published in Doklady Akademii Nauk, 2018, Vol. 481, No. 3.

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Petrova, I.O., Tyganov, S.A., Mirzoev, T.M. et al. Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?. Dokl Biochem Biophys 481, 205–207 (2018). https://doi.org/10.1134/S1607672918040075

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  • DOI: https://doi.org/10.1134/S1607672918040075

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