Skip to main content
SpringerLink
Log in

Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium

  • Biochemistry, Biophysics, and Molecular Biology
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with lipoxygenase inhibitors caffeic acid, baicalein, and nordihydroguaiaretic acid significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid metabolism in the glutoxim effect on Na+ transport in frog skin epithelium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Firsov, D., Robert-Nicoud, M., Gruender, S., et al., J. Biol. Chem., 1999, vol. 274, pp. 2743–2749.

    Article  CAS  PubMed  Google Scholar 

  2. Boldyrev, A.A. and Bulygina, E.R., Ann. N.Y. Acad. Sci., 1997, vol. 834, pp. 666–668.

    Article  CAS  PubMed  Google Scholar 

  3. Krutetskaya, Z.I., Lebedev, O.E., Melnitskaya, A.V., et al., Dokl. Biol. Sci., 2008, vol. 421, pp. 235–238.

    Article  CAS  PubMed  Google Scholar 

  4. Axelrod, J., Biochem. Soc. Trans., 1990, vol. 18, pp. 503–507.

    Article  CAS  PubMed  Google Scholar 

  5. Needleman, P., Turk, J., Jacksick, B.A., et al., Annu. Rev. Biochem., 1986, vol. 55, pp. 69–102.

    Article  CAS  PubMed  Google Scholar 

  6. Els, W.J. and Helman, S.H., J. Membr. Biol., 1997, vol. 155, pp. 75–87.

    Article  CAS  PubMed  Google Scholar 

  7. Krutetskaya, Z.I., Mel’nitskaya, A.V., Antonov, V.G., et al., Dokl. Biol. Sci., 2013, vol. 451, pp. 193–195.

    Article  CAS  PubMed  Google Scholar 

  8. Mel’nitskaya, A.V., Krutetskaya, Z.I., Butov, S.N., et al., in Sbornik “Aktual’nye voprosy biologicheskoi fiziki i khimii” (Actual Problems of Biological Physics and Chemistry: Collected Scientific Papers), Sevastopol’: Sevastopol. Gos. Univ., 2016, vol. 1, pp. 38–40.

    Google Scholar 

  9. Ordway, R.W., Singer, J.J., and Walsh, J.V., Trends Neurosci., 1991, vol. 14, pp. 96–100.

    Article  CAS  PubMed  Google Scholar 

  10. Piomelli, D. and Greengard, P., Trends Pharmacol. Sci., 1990, vol. 11, pp. 367–373.

    Article  CAS  PubMed  Google Scholar 

  11. Egan, M.E., Wagner, M.H., Zeitlin, P.L., et al., Amer. J. Respir. Cell. Mol. Biol., 1992, vol. 7, pp. 500–506.

    Article  CAS  Google Scholar 

  12. Cantiello, H.F., Patenaude, C.R., Codina, J., et al., J. Biol. Chem., 1990, vol. 265, pp. 21624–21628.

    CAS  PubMed  Google Scholar 

  13. Imig, J.D. and Khan, M.A., Compr. Physiol., 2015, vol. 15, pp. 423–441.

    Article  Google Scholar 

  14. Perico, N., Cornejo, R.P., Benigni, A., et al., J. Amer. Soc. Nephrol., 1991, vol. 2, pp. 57–59.

    CAS  Google Scholar 

  15. González-Núñez, D., Solé, M., Natarajan, R., et al., Kidney Int., 2005, vol. 67, pp. 178–186.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, A. V. Melnitskaya, V. G. Antonov & A. D. Nozdrachev

Authors
  1. Z. I. Krutetskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Melnitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. G. Antonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. D. Nozdrachev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Z. I. Krutetskaya.

Additional information

Original Russian Text © Z.I. Krutetskaya, A.V. Melnitskaya, V.G. Antonov, A.D. Nozdrachev, 2017, published in Doklady Akademii Nauk, 2017, Vol. 474, No. 3, pp. 374–377.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krutetskaya, Z.I., Melnitskaya, A.V., Antonov, V.G. et al. Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium. Dokl Biochem Biophys 474, 193–195 (2017). https://doi.org/10.1134/S1607672917030073

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672917030073

Search

Navigation