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Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines

  • Biochemistry, Biophysics and Molecular Biology
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Abstract

The expression level of the genes encoding six selenocysteine-containing human proteins was determined in the brain, cervical, liver, breast, prostate, and human fibrosarcoma cancer cells. It was found that a high level of expression in all studied types genes of tumor cells is characteristic for selh, selk, and selm genes, encoding SelH, SelK, and SelM proteins, respectively, whereas a complete lack of such expression was shown for gpx-6, selv, and sels genes. The results of this work can be regarded as a major prerequisite for further studies on the role of the three selenoproteins SelH, SelK, and SelM in the regulation of carcinogenesis processes associated with these types of cancer.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 2, Pushchino, Moscow oblast, 142290, Russia

    E. G. Varlamova, M. V. Goltyaev & E. E. Fesenko

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  1. E. G. Varlamova
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  2. M. V. Goltyaev
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  3. E. E. Fesenko
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Correspondence to E. G. Varlamova.

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Original Russian Text © E.G. Varlamova, M.V. Goltyaev, E.E. Fesenko, 2016, published in Doklady Akademii Nauk, 2016, Vol. 468, No. 4, pp. 456–458.

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Varlamova, E.G., Goltyaev, M.V. & Fesenko, E.E. Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines. Dokl Biochem Biophys 468, 203–205 (2016). https://doi.org/10.1134/S1607672916030121

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  • DOI: https://doi.org/10.1134/S1607672916030121

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