Abstract
The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.
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Original Russian Text © T.N. Portseva, A.V. Brechalov, E.A. Dukhanina, A.G. Stepchenko, E.V. Pankratova, S.G. Georgieva, 2016, published in Doklady Akademii Nauk, 2016, Vol. 467, No. 4, pp. 481–483.
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Portseva, T.N., Brechalov, A.V., Dukhanina, E.A. et al. Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells. Dokl Biochem Biophys 467, 121–123 (2016). https://doi.org/10.1134/S1607672916020125
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DOI: https://doi.org/10.1134/S1607672916020125