Abstract
The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.
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Published in Russian in Doklady Akademii Nauk, 2015, Vol. 464, No. 6, pp. 753–757.
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Yanshole, L.V., Yanshole, V.V., Snytnikova, O.A. et al. Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. Dokl Biochem Biophys 464, 341–345 (2015). https://doi.org/10.1134/S1607672915050191
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DOI: https://doi.org/10.1134/S1607672915050191