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Synthesis and Biological Evaluation of Malononitrile-Based Sulfonamide Analogs

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Abstract

4-[(2,2-Dicyanoethenyl)amino]benzenesulfonamides were synthesized by condensation of malono­nitrile with the corresponding benzenesulfonamide derivatives and triethyl orthoformate in butan-2-ol used as solvent. The structure of the synthesized compounds was confirmed by 1H and 13C NMR spectral data. The synthesized compounds were screened for their in vitro antioxidant, antibacterial, antifungal, antiurease, and carbonic anhydrase inhibitory activities, and some of them showed excellent antioxidant and antibacterial activities.

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ACKNOWLEDGMENTS

The authors are thankful to the Department of Chemistry, The Islamia University Bahawalpur, for supporting this research work.

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Authors and Affiliations

  1. Department of Chemistry, The Islamia University of Bahawalpur, 63100, Bahawalpur, Punjab, Pakistan

    S. Mubeen & A. Rauf

  2. Department of Chemistry, The Women University Multan, 60000, Multan, Punjab, Pakistan

    S. Mubeen

  3. Department of Chemistry, University of Okara, 56300, Okara, Punjab, Pakistan

    H. Ullah

  4. Department of Chemistry, The Government Sadiq College Women University, 63100, Bahawalpur, Punjab, Pakistan

    A. M. Qureshi

  5. Department of Agronomy, Bahauddin Zakariya University, 60800, Multan, Punjab, Pakistan

    G. S. Hussain

  6. Department of Technical Services, Fatima Agri Sales and Services, 60800, Multan, Punjab, Pakistan

    G. S. Hussain

  7. Department of Chemistry, Hazara University, 21300, Mansehra, Khyber Pakhtunkhwa, Pakistan

    F. Khan

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  1. S. Mubeen
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  2. A. Rauf
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  3. H. Ullah
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  4. A. M. Qureshi
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  5. G. S. Hussain
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Correspondence to S. Mubeen or H. Ullah.

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Mubeen, S., Rauf, A., Ullah, H. et al. Synthesis and Biological Evaluation of Malononitrile-Based Sulfonamide Analogs. Russ J Org Chem 57, 1694–1699 (2021). https://doi.org/10.1134/S1070428021100195

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  • DOI: https://doi.org/10.1134/S1070428021100195

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