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Heterocyclic analogs of prostaglandines: IV. Synthesis of 3,7-interphenylene 3,10(11)-dioxa-13-azaprostanoids and 9-oxa-7-azaprostanoids based on tetronic acid and aromatic aldehydes

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Abstract

An approach was developed to the synthesis of stable in metabolism 3,7-interphenylene 3,10-dioxa-13-aza-and 3,11-dioxa-13-azaprostanoids, and also 9-oxa-7-azaprostanoids with interphenylene and terminal phenyl fragments in the ω-chain based on 3-(alkoxybenzylidene)-and 3-(3-phenylallylidene)tetrahydrofuran-2,4-diones obtained by Knoevenagel condensation of tetronic acid with alkoxy-substituted aromatic aldehydes and cinnamic aldehyde.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus’, Minsk, 220141, Belarus’

    F. S. Pashkovskii, E. M. Shchukina, M. G. Gribovskii & F. A. Lakhvich

Authors
  1. F. S. Pashkovskii
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  2. E. M. Shchukina
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  3. M. G. Gribovskii
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  4. F. A. Lakhvich
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Corresponding author

Correspondence to F. S. Pashkovskii.

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Original Russian Text © F.S. Pashkovskii, E.M. Shchukina, M.G. Gribovskii, F.A. Lakhvich, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 5, pp. 667–680.

For communication III, see [1].

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Pashkovskii, F.S., Shchukina, E.M., Gribovskii, M.G. et al. Heterocyclic analogs of prostaglandines: IV. Synthesis of 3,7-interphenylene 3,10(11)-dioxa-13-azaprostanoids and 9-oxa-7-azaprostanoids based on tetronic acid and aromatic aldehydes. Russ J Org Chem 44, 657–670 (2008). https://doi.org/10.1134/S1070428008050047

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  • DOI: https://doi.org/10.1134/S1070428008050047

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