Abstract
The influence of preparation conditions on the size characteristics and stability of particles of aqueous dispersions of positively and negatively charged polyelectrolyte complexes based on N-succinyl chitosan and poly-N,N-diallyl-N,N-dimethylammonium chloride was studied. An increase in the concentrations of the initial polymer solutions, irrespective of the order of their mixing and the charge of the complex, makes narrower the interval of the molar ratios of the initial polyelectrolytes at which the dispersions of particles of the complexes exhibit aggregation stability. The widest interval of molar ratios at which the dispersions are stable (0.20–0.55) is observed for systems of negatively charged complexes with the initial concentration of the components of 0.05%. In the presence of 0.1 М NaCl, the initial particle radius in both types of complexes decreases to 75–80 nm. Addition of more concentrated sodium chloride solutions, especially into systems based on positively charged complexes, leads to an increase in the initial particle radius to 90–700 nm. With time, the particle size increases, and variation of the component molar ratio does not noticeably affect the particle size of the complexes. The mean particle size of polyelectrolyte complexes in the region of relative sedimentation stability of disperse systems is 75–403 nm, which opens prospects for using these particles as drug carriers for targeted delivery.
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Translated from Zhurnal Prikladnoi Khimii, No. 1, pp. 42–48, December, 2022 https://doi.org/10.31857/S0044461822010054
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Bazunova, M.V., Mustakimov, R.A. & Bakirova, E.R. Conditions of Formation of Stable Polyelectrolyte Complexes Based on N-Succinyl Chitosan and Poly-N,N-diallyl-N,N-dimethylammonium Chloride. Russ J Appl Chem 95, 46–52 (2022). https://doi.org/10.1134/S1070427222010062
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DOI: https://doi.org/10.1134/S1070427222010062