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Synthesis of Selenium(0) and Zinc(II) Biomolecules in Nano-Structured Forms as New Antioxidant Agents: Chemical and Biological Studies

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Abstract

In this paper, two new complexes of selenium caffeine, [Se(Caf)4], and zinc α-tocopherol, [Zn(α-Tpl)2(NO3)2], are synthesized. The structures of complexes are characterized by IR, Raman and 1H NMR spectra, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and thermogravimetric (TG/DTG) analysis. According to conductivity measurements the complexes are non-electrolytes. Spectroscopic studies of Se0 caffeine complex indicate its monodentate coordination via nitrogen atom N9 at 1: 4 molar ratio metal-to-ligand. In [Zn(α-Tpl)2(NO3)2], α-Tpl chelate is coordinated as a monodentate ligand via oxygen atom of the hydroxyl group with 1: 2 metal-to-ligand molar ratio. The percentage scavenging activity of hydroxyl radical (IC50 = 0.21 and 0.32 µg/mL), DPPH (0.17 and 0.30 µg/mL) and superoxide anion scavenging activity (0.18 and 0.32 µg/mL) indicate that selenocaffeine complex is of higher potential antioxidant activity than zinc(II) α-tocopherol complex.

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References

  1. Bordoni, A., Cabrini, L., Marchetti, M., Danesi, F., Bochicchio, D., Biagi, P.L., and Maranesi, M., Ann. Nutr. Metab., 2006, vol. 50(3), p. 305. doi https://doi.org/10.1159/000093267

    Article  CAS  PubMed  Google Scholar 

  2. Vivane, P.S., Danubia, B.S., Marcio, W.F., Nogueira, C.W., and Rocha, J.B.T., Z. Gilso. Chem. Biol. Inter., 2009, vol. 177, p. 28. doi https://doi.org/10.1016/j.cbi.2008.10.007

    Article  CAS  Google Scholar 

  3. Bode, A.M. and Dong, Z., Cancer Lett., 2007, vol. 247, p. 26. doi https://doi.org/10.1016/j.canlet.2006.03.032.

    Article  CAS  PubMed  Google Scholar 

  4. Jayawardena, R., Ranasingha, P., Galappatthy, P., Malkanthi, R., Constantine, R.G., and Katulanda, P., Diabetol. Metabol. Syndr., 2012, vol. 4, p. 13. doi https://doi.org/10.1186/1758-5996-4-13

    Article  CAS  Google Scholar 

  5. Noormagi, A., Gavilova, J., Smirnova, J., Tougu, V., and Palumaa, P., Biochem. J., 2012, vol. 430, p. 511. doi https://doi.org/10.1042/BJ20100627

    Article  Google Scholar 

  6. Roldi, L.P., Pereira, V.R., Tronchini, E.A., Rizo, V.G., Scoaris, C.R., Zanoni, J.N., and Natali, M.R., BMC Gastroenterol., 2009, vol. 9, p. 88. doi https://doi.org/10.1186/1471-230X-9-88

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Refat, M.S. and El-Sabawy, K.M., Bull. Mater. Sci., 2011, vol. 34(4), p. 873. doi https://doi.org/10.1007/s12034-011-0208-z

    Google Scholar 

  8. Iovu, M.S., Kamitsos, E.I., Varsamis, C.P.E., Boolchand, P., and Popescu, M., Chalcogenide Lett., 2005, vol. 2(3), p. 21.

    CAS  Google Scholar 

  9. Kovanda, V., Vlček, M., and Jain, H., J. Non-Cryst. Solids, 2003, vols. 326–327, p. 88. doi https://doi.org/10.1016/S0022-3093(03)00383-1

    Article  CAS  Google Scholar 

  10. Ingole, A.R., Thakare, S.R., Khati, N.T., Wankhade, A.V., and Burghate, D.K., Chalcogenide Lett., 2010, vol. 7, p. 485.

    CAS  Google Scholar 

  11. Scherrer, P., Göttinger Nachrichten Gesell., 1918, vol. 2, p. 98. doi https://doi.org/10.1007/978-3-662-33915-2_7

    Google Scholar 

  12. Smirnoff, N. and Cumbes, Q.J., Phytochem., 1989, vol. 28, p. 1057. doi https://doi.org/10.1016/0031-9422(89)80182-7

    Article  CAS  Google Scholar 

  13. Kwon, Y.I., Apostolidis, E., Kim, Y.C., and Shetty, K., J. Med. Food, 2007, vol. 10, p. 266. doi https://doi.org/10.1089/jmf.2006.234

    Article  CAS  PubMed  Google Scholar 

  14. Liu, F., Ooi, V.E.C., and Chang, S.T., Life Science, 1979, vol. 60, p. 763. doi https://doi.org/10.1016/S0024-3205(97)00004-0

    Article  Google Scholar 

  15. Sndecor, G.W. and Cochran, W.G., Statistical Methods, Iowa: Lowa State Univ. Press, 1980, 7 ed.

    Google Scholar 

  16. Refat, M.S., J. Mol. Struct., 2007, vol. 842, nos. 1–3, p. 24. doi https://doi.org/10.1016/j.molstruc.2006.12.006

    Article  CAS  Google Scholar 

  17. Kettle, S.F.A., Coordination Compounds, London: Thomas Nelson and Sons, 1975, p. 165.

    Google Scholar 

  18. Ucun, F., Saglam, A., and Guclu, V., Spectrochim. Acta, Part A, 2007, vol. 67, p. 342. doi https://doi.org/10.1016/j.saa.2006.07.029

    Article  CAS  Google Scholar 

  19. David, L., Cozar, O., Forizs, E., Craciun, C., Ristoiu, D., and Balan, C., Spectrochim. Acta, Part A, 1999, vol. 55, p. 2559. doi https://doi.org/10.1016/S1386-1425(99)00115-8

    Article  Google Scholar 

  20. Satwinder, S., Jasjest, K., and Gurvinder, S., Metal Based Drugs, 1995, vol. 2, p. 13. doi https://doi.org/10.1155/MBD.1995.13

    Article  Google Scholar 

  21. Colacio, E., Lopez, J.D., and Salas, J.M., Can. J. Chem., 1983, vol. 61, p. 2506. doi https://doi.org/10.1139/v83-432

    Article  Google Scholar 

  22. Nakamoto, K., Infrared and Raman Spectra of Inorganic and Coordination Compounds, New York: Wiley, 1978.

    Google Scholar 

  23. Ross, S.D. and Goldsmith, J.A., Spectrochim. Acta, 1964, vol. 20, p. 781. doi https://doi.org/10.1016/0371-1951(64)80077-1

    Article  CAS  Google Scholar 

  24. Ross, S.D., Inorganic Infrared and Raman Spectra, London: McGraw Hill, 1972.

    Google Scholar 

  25. Gulcin, I., Life Sci., 2006, vol. 78, p. 803. doi https://doi.org/10.1016/j.lfs.2005.05.103

    Article  CAS  PubMed  Google Scholar 

  26. Liu, C.Z., Yu, J.C., Zhang, X.Z., Wang, T., and Han, J.X., Neurosci. Lett., 2006, vol. 393(1), p. 45. doi https://doi.org/10.1016/j.neulet.2005.09.049

    Article  CAS  PubMed  Google Scholar 

  27. Soare, J.R., Dinis, T.C.P., Cunha, A.P., and Almeidd, L.M., Free Radic. Res., 1997, vol. 26, p. 469. doi https://doi.org/10.3109/10715769709084484

    Article  Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif, 21974, Saudi Arabia

    T. Altalhi, M. I. Kobeasy, A. A. Gobouri, G. A. Al Shehry & M. S. Refat

  2. Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt

    M. I. Kobeasy

  3. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, P.O. 9168, 21955, Saudi Arabia

    Enas Aljuhani

  4. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Port Fuad, Egypt

    M. S. Refat

Authors
  1. T. Altalhi
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  2. M. I. Kobeasy
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  3. A. A. Gobouri
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  4. G. A. Al Shehry
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  5. Enas Aljuhani
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  6. M. S. Refat
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Correspondence to M. S. Refat.

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Altalhi, T., Kobeasy, M.I., Gobouri, A.A. et al. Synthesis of Selenium(0) and Zinc(II) Biomolecules in Nano-Structured Forms as New Antioxidant Agents: Chemical and Biological Studies. Russ J Gen Chem 89, 800–805 (2019). https://doi.org/10.1134/S1070363219040261

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  • DOI: https://doi.org/10.1134/S1070363219040261

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