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Design, Synthesis and Anticancer Evaluation of Novel Furan Sulphonamide Derivatives

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Abstract

A series of novel furan sulphonamide derivatives 13a–13j was synthesized. The structures of the compounds are confirmed by 1H and 13C NMR, and mass spectra. All newly synthesized compounds were evaluated for their anticancer activity against three human cancer cell lines, including breast cancer cell (MCF-7), lung cancer cell (A549) and melanoma cancer cell (A-375). The compounds 13a–13c, 13e, 13g–13j demonstrated the activity higher than the positive control.

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References

  1. Pettit, G.R., Singh, S.B., Hamel, E., Lin, C.M., Alberts, D.S., and Garcia-Kendal, D., Experientia, 1989, vol. 45, p. 209.

    Article  CAS  PubMed  Google Scholar 

  2. Tron, G.C., Pirali, T., Sorba, G., Pagliai, F., Busacca, S., and Genazzani, A.A., J. Med. Chem., 2006, vol. 49, p. 3033. doi https://doi.org/10.1021/jm0512903

    Article  CAS  PubMed  Google Scholar 

  3. Siemann, D.W., Chaplin, D.J., and Walicke, P.A., Expert. Opin. Invest. Drugs., 2009, vol. 18, p. 189. doi https://doi.org/10.1517/13543780802691068

    Article  CAS  Google Scholar 

  4. Hori, K. and Saito, S., Br. J. Cancer., 2003, vol. 89, p. 1334. doi https://doi.org/10.1021/acsomega.7b01784

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lin, C.M., Ho, H.H., Pettit, G.R., and Hamel, E., Biochemistry, 1989, vol. 28, p. 6984. doi https://doi.org/10.1021/bi00443a031

    Article  CAS  PubMed  Google Scholar 

  6. Pettit, G.R., Singh, S.B., Boyd, M.R., Hamel, E., Pettit, R.K., Schmidt, J.M., and Hogan, F., J. Med. Chem., 1995, vol. 38, p. 1666. doi https://doi.org/10.1021/jm00010a011

    Article  CAS  PubMed  Google Scholar 

  7. Yoshino, Y., Ueda, N., Niijima, J., Sugumi, H., Kotake, Y., Koyanagi, N., Yoshimatsu, K., Asada, M., Watanabe, T., Nagasu, T., Tsukahara, K., Iijima, A., and Kitoh, K., J. Med. Chem., 1992, vol. 35, p. 2496. doi https://doi.org/10.1021/jm00091a018

    Article  CAS  PubMed  Google Scholar 

  8. Yoshimatsu, K., Yamaguchi, A., Yoshino, H., Koyanagi, N., and Kitoh, K., Cancer Res., 1997, vol. 57, p. 3208.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

    G. Purna Chander Rao, V. Ramesh & D. Ramachandran

  2. Integrated Product Development, Dr. Reddy’s Laboratories, Bachupally, Hyderabad, India

    A. Kalyan Chakravarthy

Authors
  1. G. Purna Chander Rao
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  2. V. Ramesh
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  3. D. Ramachandran
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  4. A. Kalyan Chakravarthy
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Correspondence to G. Purna Chander Rao.

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Purna Chander Rao, G., Ramesh, V., Ramachandran, D. et al. Design, Synthesis and Anticancer Evaluation of Novel Furan Sulphonamide Derivatives. Russ J Gen Chem 89, 486–491 (2019). https://doi.org/10.1134/S1070363219030204

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  • DOI: https://doi.org/10.1134/S1070363219030204

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