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Discovery of New Quinazoline-Based Anticancer Agents as VEGFR-2 Inhibitors and Apoptosis Inducers

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Abstract

Novel quinazoline compounds have been designed and synthesized aiming to discover new anticancer agents. Additional study was carried out on the most powerful derivatives, (Xb). A cell cycle research indicated that (Xb) mostly stops the cell cycle in the G2/M phase. The Annexin V-FITC apoptosis assay revealed that (Xb) increased apoptosis when compared with the control. It also demonstrated decreased anti-apoptotic Bcl-2 protein expression and increased BAX and caspases 3 expression levels.

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ACKNOWLEDGMENTS

The authors are thankful to Taif University Researchers Supporting Project number (TURSP-2020/123), Taif University, Taif, Saudi Arabia, for their assistance.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box , 21944, Taif, 11099, Saudi Arabia

    M. F. Ahmed

  2. Department of Pharmaceutics, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

    A. S. Khalifa

  3. Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

    E. M Eed

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  1. M. F. Ahmed
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Correspondence to M. F. Ahmed.

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Ahmed, M.F., Khalifa, A.S. & Eed, E.M. Discovery of New Quinazoline-Based Anticancer Agents as VEGFR-2 Inhibitors and Apoptosis Inducers. Russ J Bioorg Chem 48, 739–748 (2022). https://doi.org/10.1134/S1068162022040033

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