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Antitumor Activity of Selenium and Search Parameters for Its New Potentially Active Derivatives

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Abstract

The trace element selenium is known to manifest antitumor activity. There is a relationship between the development of cancer and selenium content in food. Recent data demonstrated the necessity of increasing selenium consumption for the prevention and treatment of oncological diseases. Certain features of cancer cells and potential targets of selenium therapy are discussed. Both natural forms of selenium, namely, element Se, sodium selenite, L-selenocystine, L-selenomethionine, and L-methylselenocysteine, and synthetic ones, methylseleninic acid and imidoselenocarbamate derivatives, which display antitumor activity due to the generation of methylselenol and hydrogen selenide, the main anticarcinogenic metabolites, are reviewed. New promising anticancer selenium compounds, diacetophenonyl selenide, 2-methylselanyl-1-phenylethanol, and amino acids 2-amino-3-selanyl butanoic acid and 2-amino-3-(methylselanyl) butanoic acid are discussed.

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Authors and Affiliations

  1. Penza State University of Architecture and Construction, 440028, Penza, Russia

    P. A. Poluboyarinov

  2. Parafarm Corporation, 440033, Penza, Russia

    D. G. Elistratov

  3. Penza State University, 440026, Penza, Russia

    I. J. Moiseeva

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  1. P. A. Poluboyarinov
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Translated by E. Shirokova

Abbreviations: GSH, reduced glutathione; GS–SG, glutathione disulfide; MSA, methylseleninic acid; MeSec, L-methylselenocysteine; Sec, L-selenocystine; Sem, L-selenomethionine.

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Poluboyarinov, P.A., Elistratov, D.G. & Moiseeva, I.J. Antitumor Activity of Selenium and Search Parameters for Its New Potentially Active Derivatives. Russ J Bioorg Chem 46, 989–1003 (2020). https://doi.org/10.1134/S1068162020060254

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