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Isolation of pomolic acid from Chamaenerion angustifolium and the evaluation of its potential genotoxicity in bacterial test systems

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Abstract

The lipophilic components of the medicinal plant, the fireweed (Chamaenerion angustifolium), have been examined using the raw materials of a three-year harvest. Twenty eight aliphatic and six triterpene acids have been detected for the first time by chromatography—mass spectrometry analysis. It has been shown using the Ames test and the SOS chromotest that pomolic acid possesses no genotoxic and mutagenic properties.

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Abbreviations

C-MS:

chromatography—mass spectrometry

MTBE:

methyl tert-butyl ester

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Authors and Affiliations

  1. Novosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russia

    T. S. Frolova

  2. Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    O. I. Sal’nikova & T. P. Kukina

  3. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    T. A. Dudareva & O. I. Sinitsyna

Authors
  1. T. S. Frolova
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  2. O. I. Sal’nikova
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  3. T. A. Dudareva
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  4. T. P. Kukina
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  5. O. I. Sinitsyna
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Correspondence to T. S. Frolova.

Additional information

Original Russian Text © T.S. Frolova, O.I. Sal’nikova, T.A. Dudareva, T.P. Kukina, O.I. Sinitsyna, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 1, pp. 92–98.

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Frolova, T.S., Sal’nikova, O.I., Dudareva, T.A. et al. Isolation of pomolic acid from Chamaenerion angustifolium and the evaluation of its potential genotoxicity in bacterial test systems. Russ J Bioorg Chem 40, 82–88 (2014). https://doi.org/10.1134/S1068162013060046

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  • DOI: https://doi.org/10.1134/S1068162013060046

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