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Crystal structure and packing analysis of nitrofurantoin N,N-dimethylformamide solvate

  • Structure of Organic Compounds
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Abstract

The N, N′-dimethylformamide solvated crystal of the drug nitrofurantoin has been prepared and analysed by single-crystal X-ray diffraction. The two co-crystallized molecules, in the 1 : 1 stoichiometric ratio, are linked by a medium/strong N–H···O hydrogen bond (N···O is 2.759 (3) Å) and a weaker C–H···O interaction to form isolated supramolecular adducts, that in turn are packed into the lattice framework mainly through C–H···O hydrogen bonds. Two-dimensional fingerprint plots of Hirshfeld surfaces are used to visualize, analyze and compare intermolecular interactions found in the title compound and in similar structures.

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Authors and Affiliations

  1. Faculty of Medical Sciences, Krste Misirkov bb, University Goce Delcev, 2000 P.O 201, Štip, R. Macedonia

    A. Cvetkovski

  2. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, via Fossato di Mortara 17-27, I-44121, Ferrara, Italy

    V. Ferretti

Authors
  1. A. Cvetkovski
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  2. V. Ferretti
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Correspondence to A. Cvetkovski.

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Cvetkovski, A., Ferretti, V. Crystal structure and packing analysis of nitrofurantoin N,N-dimethylformamide solvate. Crystallogr. Rep. 61, 611–615 (2016). https://doi.org/10.1134/S1063774516040040

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  • DOI: https://doi.org/10.1134/S1063774516040040

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