Abstract
The influence of the P-element built into the area of the CG5017 gene on the mutation of the spineless (ss) gene was studied. It was shown that the insertion of the P-element decreased the level of transcription of CG5017 approximately twofold. Modulation of the level of transcription of the CG5017 gene helped demonstrate, for the first time, its influence on the phenotypic manifestation of the mutation of the ss gene, which shows their interaction in the process of regulation of morphogenesis of limbs in Drosophila melanogaster.
Similar content being viewed by others
References
Abu-Shaar, M. and Mann, R.S., Generation of Multiple Antagonistic Domains along the Proximodistal Axis during Drosophila Leg Development, Development, 1998, vol. 125, pp. 3821–3830.
Anholt, R.R. and Mackay, T.F., The Genetic Architecture of Odor-Guided Behavior in Drosophila melanogaster, Behav. Genet., 2001, vol. 31, pp. 17–27.
Balkashinea, I., Ein Fall Der Erbhomoosis (Die Genovariation “Aristapedia”) bei Drosophila melanogaster, W. Roux. Arch. Entw. Org., 1929, vol. 115, pp. 448–465.
Belenkaya, T., Soldatov, A., Nabirochkina, E., et al., P-Element Insertion at the Polyhomeotic Gene Leads to Formation of a Novel Chimeric Protein that Negatively Regulates Yellow Expression in P Element-Induced Alleles of Drosophila melanogaster, Genetics, 1998, vol. 150, pp. 687–697.
Brook, W.J. and Cohen, S.M., Antagonistic Interactions between Wingless and Decapentaplegic Responsible for Dorsal-Ventral Pattern in the Drosophila Leg, Science, 1996, vol. 273, pp. 1373–1377.
Cohen, S.M. and Jürgens, G., Proximal-Distal Pattern Formation in Drosophila: Cell Autonomous Requirement for Distal-Less Gene Activity in Limb Development, EMBO J., 1989, vol. 8, no. 7, pp. 2045–2055.
Crew, S. and Brenman, E., Spineless Provides a Little Backbone for Dendritic Morphogenesis, Genes. Devel., 2006, vol. 20, pp. 2773–2778.
Diaz-Benjumea, F.J., Cohen, B., and Cohen, S.M., Cell Interaction between Compartments Establishes the ProximalDistal Axis of Drosophila Legs, Nature, 1994, vol. 372, pp. 175–179.
Dubnau, J., Chiang, A., Grady, L., et al., The Staufen/Pumilio Pathway Is Involved in Drosophila Long-Term Memory, Curr. Biol., 2003, vol. 13, pp. 286–296.
Duncan, D., Burgess, E., and Duncan, I., Control of Distal Antennal Identity and Tarsal Development in Drosophila by Spineless-Aristapedia, a Homolog of the Mammalian Dioxin Receptor, Genes. Devel., 1998, vol. 12, pp. 1290–1303.
Emmons, R., Duncan, D., Estes, P., et al., The Spineless-Aristapedia and Tango BHLH-PAS Proteins Interact to Control Antennal and Tarsal Development in Drosophila, Development, 1999, vol. 126, pp. 3937–3945.
Grigliatti, T. and Suzuki, D., Temperature Sensitive Mutations in Drosophila melanogaster. VII. The Homeotic Mutant ss a40a, Proc. Natl. Acad. Sci. USA, 1971, vol. 68, pp. 1307–1311.
Gross-Bellard, M., Oudet, P., and Chambon, P., Isolation of High-Molecular-Weight DNA from Mammalian Cells, Eur. J. Biochem., 1973, vol. 36, no. 1, pp. 32–38.
Kim, M., Jan, L., and Jan, Y., The bHLH-PAS Protein Spineless is Necessary for the Diversification of Dendrite Morphology of Drosophila Dendritic Arborisation Neurons, Genes. Devel., 2006, vol. 20, pp. 2806–2819.
Kuzin, B., Dosdjanov, K., and Mazo, A., Interaction between Spineless-Aristapedia Gene and Genes from Antennapedia and Bithorax Complexes of Drosophila melanogaster, Int. J. Devel. Biol., 1997, vol. 41, pp. 867–875.
Kuzin, B.A., Doszhanov, K.T., Simonova, O.B., et al., A New Allele Variant of the ss a Gene and its Involvement in the Control of Proliferation of Stem Cells of Leg and Antennal Imaginal Discs in Drosophila melanogaster, Ontogenez, 1991, vol. 22, pp. 212–217.
Lecuit, T. and Cohen, S., Proximal-Distal Axis Formation in the Drosophila Leg, Nature, 1997, vol. 388, pp. 139–145.
Modestova, E.A., Kopytova, D.V., Georgieva, S.G., and Simonova, O.B., The Use of the Genetic System of the R-Rh Chimeric Protein to Repress Transcription of the Leg-Arista-Wing Complex Gene in Drosophila, Genetika, 2003, vol. 39, no. 5, pp. 713–716.
Park, Y.J. and Luger, K., The Structure of Nucleosome Assembly Protein 1, Proc. Natl. Acad. Sci. USA, 2006, vol. 103, no. 5, pp. 1248–53.
Rodriguez, P., Munroe, D., Prawitt, D., et al., Functional Characterization of Human Nucleosome Assembly Protein-2 (NAP1L4) Suggests a Role as a Histone Chaperone, Genomics, 1997, vol. 44, no. 3, pp. 253–65.
Struhl, G., Spineless-Aristapedia: A Homeotic Gene that Does Control the Development of Specific Compartment in Drosophila, Genetics, 1982, vol. 102, pp. 737–749.
Wu, J. and Cohen, S.M., Proximodistal Axis Formation in the Drosophila Leg: Subdivision into Proximal and Distal Domains by Homothorax and Distal-Less, Development, 1999, vol. 126, pp. 109–117.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text ¢ B.A. Kuzin, E.A. Modestova, Yu.E. Vorontsova, O.G. Zatsepina, A.S. Mikaelyan, M.V. Slezinger, O.B. Simonova, 2010, published in Ontogenez, 2010, Vol. 41, No. 5, pp. 364–369.
Rights and permissions
About this article
Cite this article
Kuzin, B.A., Modestova, E.A., Vorontsova, Y.E. et al. Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster . Russ J Dev Biol 41, 312–317 (2010). https://doi.org/10.1134/S1062360410050061
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1062360410050061