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Transcriptional factor Pitx2: Localization during triton retina regeneration

  • Developmental Biology
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Abstract

For the first time immune-chemical analysis of transcriptional factor Pitx2 localization during triton retina regeneration after its removal and also in tissues of a nonoperated eye of an adult triton has been carried out. Protein Pitx2 has been found in the nucleus of the earliest neuroblasts that form the germ of the retina. At a later stage of retina regeneration, Pitx2 was found in the nucleus of differentiating cells of ganglionic layers that correspond to Pitx2 protein localization in the native retina. Protein Ptix2 has also been found in the nucleus of less differentiated cells of the peripheral region of regenerative and native retina. It was demonstrated that protein Pitx2 is expressed not only in retina but also in other tissues of the posterior sector of the eye (pigment epithelium, choroid) using immune-histochemical and Western blot hybridization. It is supposed that transcriptional factor Pitx2 has been involved in the control of subsequent stages of retina regeneration from pigment epithelium cells.

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Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia

    P. P. Avdonin, E. N. Grigoryan & Yu. V. Markitantova

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  1. P. P. Avdonin
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  2. E. N. Grigoryan
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  3. Yu. V. Markitantova
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Correspondence to Yu. V. Markitantova.

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Original Russian Text © P.P. Avdonin, E.N. Grigoryan, Yu.V. Markitantova, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 3, pp. 283–288.

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Avdonin, P.P., Grigoryan, E.N. & Markitantova, Y.V. Transcriptional factor Pitx2: Localization during triton retina regeneration. Biol Bull Russ Acad Sci 37, 231–235 (2010). https://doi.org/10.1134/S1062359010030039

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