Skip to main content
SpringerLink
Log in

Chitosan and its hydrophobic derivatives: Preparation and aggregation in dilute aqueous solutions

  • Published:
Polymer Science Series A Aims and scope Submit manuscript

Abstract

This review surveys the main methods of preparing chitosan and its hydrophobic derivatives and their influence on the microstructure of polymers. The experimental data on the aggregation of these polymers in dilute aqueous solutions are summarized. Basic factors affecting aggregation are analyzed, and its general regularities are revealed. It is shown that, in the case of both chitosan and its hydrophobic derivatives, the formation of aggregates is governed by the competition of attraction of associating groups promoting aggregation and their repulsion arising from the presence of charged units and counterions hindering aggregation. Various aggregate models that were proposed for chitosan derivatives with different main-chain lengths and different contents of associating groups are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Rinaudo, Prog. Polym. Sci. 31, 603 (2006).

    Article  CAS  Google Scholar 

  2. Material Science of Chitin and Chitosan, Ed. by T. Uragami and S. Tokura (Springer, Tokyo, 2006).

    Google Scholar 

  3. Chitin and Chitosan: Nature, Synthesis, and Application, Ed. by V. P. Varlamov, S. V. Nemtsev, and V. E. Tikhonov (Ross. Khitin. Obshch., Moscow, 2010) [in Russian].

    Google Scholar 

  4. G. P. Martin, J. Macromol. Sci., Pure Appl. Chem. 32, 629 (1995).

    Article  Google Scholar 

  5. V. P. Bykov, in Proceedings of 5th All-Russia Conf. “New Perspectives in Chitin and Chitosan Investigation,” Shchelkovo, 1999, p. 15.

  6. V. M. Bykova, L. I. Krivosheina, O. I. Glazunov, and E. A. Ezhova, in Proceedings of 6th All-Russia Conference “New Perspectives in Chitin and Chitosan Investigation,” Shchelkovo, 2001, p. 147.

  7. Chitin and Chitosan. Sources, Chemistry, Biochemistry, Physical Properties and Applications, Ed. by G. SkjakBrek, P. Anthonsen, and P. Sandford (Elsevier, London, 1989).

    Google Scholar 

  8. E. I. Rabea, M. E.-T. Badawy, C. V. Stevens, G. Smagghe, and W. Steurbaut, Biomacromolecules 4, 1457 (2003).

    Article  CAS  Google Scholar 

  9. H. Pospieszny, S. Chirkov, and J. Atabekov, Plant Sci. 79, 63 (1991).

    Article  CAS  Google Scholar 

  10. V. F. Smirnov, L. A. Smirnova, O. V. Dormidontova, and M. V. Sergeeva, in Proceedings of 6th All-Russia Conference “New Perspectives in Chitin and Chitosan Investigation,” Shchelkovo, 2001, p. 360.

  11. Natural Chelating Polymers: Alginic Acid, Chitin and Chitosan, Ed. by R. A. A. Muzzarelli (Pergamon, New York, 1973).

    Google Scholar 

  12. L. A. Nud’ga, Doctoral Dissertation in Chemistry (Inst. of Macromolecular Compounds, St. Petersburg, 2006).

    Google Scholar 

  13. M. N. V. Ravi Kumar, R. A. A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A. J. Domb, Chem. Rev. 104, 6017 (2004).

    Article  Google Scholar 

  14. V. R. Sinha, A. K. Singla, S. Wadhawan, R. Kaushik, R. Kumria, K. Bansal, and S. Dhawan, Int. J. Pharm. 274, 1 (2004).

    Article  CAS  Google Scholar 

  15. C. Lehr, J. A. Bouwstra, E. H. Schacht, and H. E. Junginger, Int. J. Pharm. 78, 43 (1992).

    Article  CAS  Google Scholar 

  16. P. He, S. S. Davis, and L. Illum, Int. J. Pharm. 166, 75 (1998).

    Article  CAS  Google Scholar 

  17. X. F. Liu, Y. L. Guan, D. Z. Yang, Z. Li, and K. D. Yao, J. Appl. Polym. Sci. 79, 1324 (2001).

    Article  CAS  Google Scholar 

  18. G. Ikinci, S. Senel, H. Akincibay, S. Kas, S. Ercis, C. G. Wilson, and A. A. Hincal, Int. J. Pharm. 235, 121 (2002).

    Article  CAS  Google Scholar 

  19. S. Dhawan, A. K. Singla, and V. R. Sinha, AAPS PharmSciTech 5, 1 (2004).

    Article  Google Scholar 

  20. O. E. Philippova, T. Akitaya, I. R. Mullagaliev, A. R. Khokhlov, and K. Yoshikawa, Macromolecules 38, 9359 (2005).

    Article  CAS  Google Scholar 

  21. R. Riva, H. Ragelle, A. des Rieux, N. Duhem, C. Jérôme, and V. Préat, Adv. Polym. Sci. 244, 19 (2011).

    Article  Google Scholar 

  22. O. E. Philippova, D. Hourdet, R. Audebert, and A. R. Khokhlov, Macromolecules 30, 8278 (1997).

    Article  CAS  Google Scholar 

  23. O. E. Philippova, Polymer Science, Ser. C 42, 208 (2000) [Vysokomol. Soedin., Ser. C 42, 2328 (2000)].

    Google Scholar 

  24. I. V. Blagodatskikh, M. V. Sutkevich, N. L. Sitnikova, N. A. Churochkina, T. A. Pryakhina, O. E. Philippova, and A. R. Khokhlov, J. Chromatogr. A 976, 155 (2002).

    Article  CAS  Google Scholar 

  25. Yu. A. Shashkina, Yu. D. Zaroslov, V. A. Smirnov, O. E. Philippova, A. R. Khokhlov, T. A. Pryakhina, and N. A. Churochkina, Polymer 44, 2289 (2003).

    Article  CAS  Google Scholar 

  26. O. E. Philippova, A. S. Andreeva, A. R. Khokhlov, A. K. Islamov, A. I. Kuklin, and V. I. Gordeliy, Langmuir 19, 7240 (2003).

    Article  CAS  Google Scholar 

  27. A. S. Andreeva, A. I. Fomenkov, A. K. Islamov, A. I. Kuklin, O. E. Philippova, and A. R. Khokhlov, Polymer Science, Ser. A 47, 194 (2005) [Vysokomol. Soedin., Ser. A 47, 338 (2005)].

    Google Scholar 

  28. A. V. Kabanov and V. A. Kabanov, Bioconjug. Chem. 6, 7 (1995).

    Article  CAS  Google Scholar 

  29. M. Kurisawa, M. Yokoyama, and T. J. Okano, J. Controlled Release 68, 1 (2000).

    Article  CAS  Google Scholar 

  30. T. Sato, T. Kawakami, N. Shirakawa, and Y. Okahata, Bull. Chem. Soc. Jpn. 68, 2709 (1995).

    Article  CAS  Google Scholar 

  31. Y. H. Kim, S. H. Gihm, C. R. Park, K. Y. Lee, T. W. Kim, I. C. Kwon, H. Chung, and S. Y. Jeong, Bioconjug. Chem. 12, 932 (2001).

    Article  CAS  Google Scholar 

  32. K. Y. Lee, W. H. Jo, I. C. Kwon, Y. H. Kim, and S. Y. Jeong, Langmuir 14, 2329 (1998).

    Article  CAS  Google Scholar 

  33. W. G. Liu, X. Zhang, S. J. Sun, G. J. Sun, K. D. Yao, D. C. Liang, G. Guo, and J. Y. Zhang, Bioconjug. Chem. 14, 782 (2003).

    Article  CAS  Google Scholar 

  34. W. Liu, S. J. Sun, X. Zhang, and K. D. Yao, J. Biomater. Sci., Polym. Ed. 14, 851 (2003).

    Article  CAS  Google Scholar 

  35. E. Buhler and M. Rinaudo, Macromolecules 33, 2098 (2000).

    Article  CAS  Google Scholar 

  36. P. Sorlier, A. Denuzière, C. Viton, and A. Domard, Biomacromolecules 2, 765 (2001).

    Article  CAS  Google Scholar 

  37. P. Sorlier, C. Viton, and A. Domard, Biomacromolecules 3, 1336 (2002).

    Article  CAS  Google Scholar 

  38. P. Sorlier, C. Rochas, I. Morfin, C. Viton, and A. Domard, Biomacromolecules 4, 1034 (2003).

    Article  CAS  Google Scholar 

  39. S. Popa-Nita, P. Alcouffe, C. Rochas, L. David, and A. Domard, Biomacromolecules 11, 6 (2010).

    Article  CAS  Google Scholar 

  40. S. Kulikov, V. Tikhonov, I. Blagodatskikh, E. Bezrodnykh, S. Lopatin, R. Khairullin, Y. Philippova, and S. Abramchuk, Carbohydr. Polym. 87, 545 (2012).

    Article  CAS  Google Scholar 

  41. E. V. Korchagina, Candidate’s Dissertation in Mathematics and Physics (Moscow State Univ., Moscow, 2012).

    Google Scholar 

  42. E. V. Korchagina and O. E. Philippova, Biomacromolecules 11, 3457 (2010).

    Article  CAS  Google Scholar 

  43. M. W. Anthonsen, K. M. Vårum, A. M. Hermansson, O. Smidsrød, and D. A. Brant, Carbohydr. Polym. 25, 13 (1994).

    Article  CAS  Google Scholar 

  44. G. Lamarque, J.-M. Lucas, C. Viton, and A. Domard, Biomacromolecules 6, 131 (2005).

    Article  CAS  Google Scholar 

  45. O. E. Philippova, E. V. Volkov, N. L. Sitnikova, A. R. Khokhlov, J. Desbrières, and M. Rinaudo, Biomacromolecules 2, 483 (2001).

    Article  CAS  Google Scholar 

  46. M. Amiji, Carbohydr. Polym. 26, 211 (1995).

    Article  CAS  Google Scholar 

  47. T. Matsumoto, M. Kawai, and T. Masuda, Biopolymers 31, 1721 (1991).

    Article  CAS  Google Scholar 

  48. M. H. Ottøy, K. M. Vårum, B. E. Christensen, M. W. Anthonsen, and O. Smidsrød, Carbohydr. Polym. 31, 253 (1996).

    Article  Google Scholar 

  49. C. Schatz, C. Pichot, T. Delair, C. Viton, and A. Domard, Langmuir 19, 9896 (2003).

    Article  CAS  Google Scholar 

  50. N. Kubota and Y. Eguchi, Polym. J. (Tokyo) 29, 123 (1997).

    Article  CAS  Google Scholar 

  51. C. Schatz, C. Viton, T. Delair, C. Pichot, and A. Domard, Biomacromolecules 4, 641 (2003).

    Article  CAS  Google Scholar 

  52. K. Kurita, T. Sannan, and Y. Iwakura, Makromol. Chem. 178, 3197 (1977).

    Article  CAS  Google Scholar 

  53. I. A. Sogias, V. V. Khutoryanskiy, and A. C. Williams, Macromol. Chem. Phys. 211, 426 (2010).

    Article  CAS  Google Scholar 

  54. O. E. Philippova, E. V. Korchagina, E. V. Volkov, V. A. Smirnov, A. R. Khokhlov, and M. Rinaudo, Carbohydr. Polym. 87, 687 (2012).

    Article  CAS  Google Scholar 

  55. W. Y. Chen, C. H. Hsu, J. R. Huang, M. L. Tsai, and R. H. Chen, J. Polym. Res. 18, 1385 (2011).

    Article  CAS  Google Scholar 

  56. I. A. Sogias, A. C. Williams, and V. V. Khutoryanskiy, Biomacromolecules 9, 1837 (2008).

    Article  CAS  Google Scholar 

  57. S. R. Jameela and A. Jayakrishnan, Biomaterials 16, 769 (1995).

    Article  CAS  Google Scholar 

  58. I. Genta, M. Constantini, A. Asti, B. Conti, and L. Montanari, Carbohydr. Polym. 36, 81 (1998).

    Article  CAS  Google Scholar 

  59. O. A. C. Monteiro and C. Airoldi, Int. J. Biol. Macromol. 26, 119 (1999).

    Article  CAS  Google Scholar 

  60. F.-L. Mi, C.-Y. Kuan, S.-S. Shyu, S.-T. Lee, and S.-F. Chang, Carbohydr. Polym. 41, 389 (2000).

    Article  CAS  Google Scholar 

  61. V. Crescenzi, A. Francescangeli, A. Taglienti, D. Capitani, and L. Mannina, Biomacromolecules 4, 1045 (2003).

    Article  CAS  Google Scholar 

  62. Y. C. Wei, S. M. Hudson, J. M. Mayer, and D. L. Kaplan, J. Polym. Sci., Part A: Polym. Chem. 30, 2187 (1992).

    Article  CAS  Google Scholar 

  63. E. R. Welsh and R. R. Price, Biomacromolecules 4, 1357 (2003).

    Article  CAS  Google Scholar 

  64. H. Sashiwa and S. Aiba, Prog. Polym. Sci. 29, 887 (2004).

    Article  CAS  Google Scholar 

  65. I. Aranaz, R. Harris, and A. Heras, Curr. Org. Chem. 14, 308 (2010).

    Article  CAS  Google Scholar 

  66. M. Amidi, E. Mastrobattista, W. Jiskoot, and W. E. Hennink, Adv. Drug Delivery Rev. 62, 59 (2010).

    Article  CAS  Google Scholar 

  67. R. A. A. Muzzarelli and C. Muzzarelli, Chitosan in Pharmacy and Chemistry (ATEC, Grottammare, 2002).

    Google Scholar 

  68. L. S. Gal’braikh, Sorosovskii Obrazovat. Zh. 7, 51 (2001).

    Google Scholar 

  69. V. M. Bykova and S. V. Nemtsev, in Chitin and Chitosan: Synthesis, Properties, and Application, Ed. by K. G. Skryabin, G. A. Vikhoreva, and V. P. Varlamov (Nauka, Moscow, 2002), p. 7.

    Google Scholar 

  70. L. A. Nud’ga, E. A. Plisko, and S. N. Danilov, Zh. Obshch. Khim. 41, 2555 (1971).

    Google Scholar 

  71. S. M. Taghizadeh and G. Davari, Carbohydr. Polym. 64, 9 (2006).

    Article  CAS  Google Scholar 

  72. Y.-W. Cho, J. Jang, C. R. Park, and S.-W. Ko, Biomacromolecules 1, 609 (2000).

    Article  CAS  Google Scholar 

  73. J. Desbrières, C. Martinez, and M. Rinaudo, Int. J. Biol. Macromol. 19, 21 (1996).

    Article  Google Scholar 

  74. M. Rinaudo, R. Auzely, C. Vallin, and I. Millagaliev, Biomacromolecules 6, 2396 (2005).

    Article  CAS  Google Scholar 

  75. O. Ortona, G. D’Errico, G. Mangiapia, and D. Ciccarelli, Carbohydr. Polym. 74, 16 (2008).

    Article  CAS  Google Scholar 

  76. J. Ngimhuang, J. I. Furukawa, T. Satoh, T. Furuike, and N. Sakari, Polymer 45, 837 (2004).

    Article  CAS  Google Scholar 

  77. C. Onesippe and S. Lagerge, Colloids Surf. A 330, 201 (2008).

    Article  CAS  Google Scholar 

  78. L. A. Nud’ga, E. A. Plisko, and S. N. Danilov, Zh. Obshch. Khim. 43, 2756 (1973).

    Google Scholar 

  79. V. E. Tikhonov, E. A. Stepnova, V. G. Babak, M. A. Krayukhina, B. B. Berezin, and I. A. Yamskov, React. Funct. Polym. 68, 436 (2008).

    Article  CAS  Google Scholar 

  80. G.-B. Jiang, D. Quan, K. Liao, and H. Wang, Carbohydr. Polym. 66, 514 (2006).

    Article  CAS  Google Scholar 

  81. J. Zhang, X. G. Chen, Y. Y. Li, and C. S. Liu, Nanomed.: Nanotechnol. Biol. Med. 3, 258 (2007).

    Article  CAS  Google Scholar 

  82. S. Aiba, Int. J. Biol. Macromol. 13, 40 (1991).

    Article  CAS  Google Scholar 

  83. S. Hirano, Y. Yanaguchi, and M. Kamiya, Macromol. Biosci. 3, 629 (2003).

    Article  CAS  Google Scholar 

  84. E. Nandanan, N. R. Jana, and J. Y. Ying, Adv. Mater. (Weinheim, Fed. Repub. Ger.) 20, 2068 (2008).

    Article  CAS  Google Scholar 

  85. C. Le Tien, M. Lacroix, P. Ispas-Szabo, and M.-A. Mateescu, J. Controlled Release 93, 1 (2003).

    Article  CAS  Google Scholar 

  86. F. Q. Hu, M. D. Zhao, H. Yuan, J. You, Y. Z. Du, and S. A. Zeng, Int. J. Pharm. 315, 158 (2006).

    Article  CAS  Google Scholar 

  87. F. Q. Hu, G. F. Ren, H. Yuan, Y. Z. Du, and S. Zheng, Colloids Surf. B 50, 97 (2006).

    Article  CAS  Google Scholar 

  88. C. G. Liu, X. G. Chen, and H. J. Park, Carbohydr. Polym. 62, 293 (2005).

    Article  CAS  Google Scholar 

  89. C.-G. Liu, K. G. H. Desai, X.-G. Chen, and H.-J. Park, J. Agric. Food Chem. 53, 1728 (2005).

    Article  CAS  Google Scholar 

  90. K. Park, J. H. Kim, Y. S. Nam, S. Lee, H. Y. Nam, K. Kim, J. H. Park, I. S. Kim, K. Choi, S. Y. Kim, and I. C. Kwon, J. Controlled Release 122, 305 (2007).

    Article  CAS  Google Scholar 

  91. H. Y. Hwang, I. S. Kim, I. C. Kwon, and Y. H. Kim, J. Controlled Release 128, 23 (2008).

    Article  CAS  Google Scholar 

  92. K. Park, H. Y. Hong, H. J. Moon, B. H. Lee, I. S. Kim, I. C. Kwon, and K. Rhee, J. Controlled Release 128, 217 (2008).

    Article  CAS  Google Scholar 

  93. J. M. Yu, Y. J. Li, Y. Qiu, and Y. Jin, Eur. Polym. J. 44, 555 (2008).

    Article  CAS  Google Scholar 

  94. M. Terbojevich and R. A. A. Muzzarelli, in Handbook of Hydrocolloids, Ed. by G. O. Phillips and P. A. Williams (Woodhead & CRC, Boca Raton, 2000), p. 367.

    Google Scholar 

  95. H. Sashiwa, N. Kawasaki, A. Nakayama, E. Muraki, N. Yamamoto, H. Zhu, H. Nagano, Y. Omura, H. Saimoto, Y. Shigemasa, and S. Aiba, Biomacromolecules 3, 1120 (2002).

    Article  CAS  Google Scholar 

  96. Y. Tong, S. Wang, J. Xu, B. Chua, and C. He, Carbohydr. Polym. 60, 229 (2005).

    Article  CAS  Google Scholar 

  97. Y. Wu, K. Hisada, S. Maeda, T. Sasak, and K. Sakurai, Carbohydr. Polym. 68, 766 (2007).

    Article  CAS  Google Scholar 

  98. I. I. Potemkin, K. B. Zel’dovich, and A. R. Khokhlov, Polymer Science, Ser. C 42, 154 (2000) [Vysokomol. Soedin., Ser. C 42, 2265 (2000)].

    Google Scholar 

  99. E. Yu. Kramarenko, O. E. Philippova, and A. R. Khokhlov, Polymer Science, Ser. C 48, 1 (2006) [Vysokomol. Soedin., Ser. C 48, 1216 (2006)].

    Article  Google Scholar 

  100. I. I. Potemkin, V. V. Vasilevskaya, and A. R. Khokhlov, J. Chem. Phys. 111, 2809 (1999).

    Article  CAS  Google Scholar 

  101. I. I. Potemkin, S. A. Andreenko, and A. R. Khokhlov, J. Chem. Phys. 115, 4862 (2001).

    Article  CAS  Google Scholar 

  102. Yu. D. Zaroslov, G. Fytas, M. Pitsikalis, N. Hadjichristidis, O. E. Philippova, and A. R. Khokhlov, Macromol. Chem. Phys. 206, 173 (2005).

    Article  CAS  Google Scholar 

  103. K. M. Vårum, M. W. Anthonsen, H. Grasdalen, and O. Smidsrød, Carbohydr. Polym. 211, 17 (1991).

    Google Scholar 

  104. M. Yanagisawa, Y. Kato, Y. Yoshida, and A. Isogai, Carbohydr. Polym. 66, 192 (2006).

    Article  CAS  Google Scholar 

  105. C. Qin, H. Li, Q. Xiao, Y. Liu, J. Zhu, and Y. Du, Carbohydr. Polym. 63, 367 (2006).

    Article  CAS  Google Scholar 

  106. K. Ogawa, S. Hirano, T. Miyanishi, T. Yui, and T. Watanabe, Macromolecules 17, 973 (1984).

    Article  CAS  Google Scholar 

  107. E. Belamie, A. Domard, H. Chanzy, and M.-M. Giraud-Guille, Langmuir 15, 1549 (1999).

    Article  CAS  Google Scholar 

  108. C. W. Frank, D. J. Hemker, and H. T. Oyama, ACS Symp. Ser. 467, 303 (1991).

    Article  CAS  Google Scholar 

  109. K. Okuyama, K. Noguchi, T. Miyazawa, T. Yui, and K. Ogawa, Macromolecules 30, 5849 (1997).

    Article  CAS  Google Scholar 

  110. X. Yu, A. Tanaka, K. Tanaka, and T. Tanaka, J. Chem. Phys. 97, 7805 (1992).

    Article  CAS  Google Scholar 

  111. K. Kalyanasundaram and G. K. Thomas, J. Am. Chem. Soc. 99, 2039 (1977).

    Article  CAS  Google Scholar 

  112. Yu. A. Shashkina, O. E. Philippova, V. A. Smirnov, I. V. Blagodatskikh, N. A. Churochkina, and A. R. Khokhlov, Polymer Science, Ser. A 47, 1210 (2005) [Vysokomol. Soedin., Ser. A 47, 2013 (2005)].

    Google Scholar 

  113. K. Mazeau and M. Rinaudo, Food Hydrocolloids 18, 885 (2004).

    Article  CAS  Google Scholar 

  114. S. Ercelen, X. Zhang, G. Duportail, C. Grandfils, J. Desbrières, S. Karaeva, V. Tikhonov, Y. Mely, and V. Babak, Colloids Surf. B 51, 140 (2006).

    Article  CAS  Google Scholar 

  115. L. Rayleigh, Philos. Mag. 14, 184 (1882).

    Google Scholar 

  116. A. Domard and M. Rinaudo, Polym. Commun. 25, 55 (1984).

    CAS  Google Scholar 

  117. G. A. Roberts and J. G. Domszy, Int. J. Biol. Macromol. 4, 374 (1982).

    Article  CAS  Google Scholar 

  118. M. Rinaudo, M. Milas, and P. Le Dung, Int. J. Biol. Macromol. 15, 281 (1993).

    Article  CAS  Google Scholar 

  119. A. P. Safronov, in Chitin and Chitosan: Synthesis, Properties, and Application, Ed. by K. G. Skryabin, G. A. Vikhoreva, and V. P. Varlamov (Nauka, Moscow, 2002), p. 130.

    Google Scholar 

  120. W. Burchard, Adv. Polym. Sci. 143, 113 (1999).

    Article  CAS  Google Scholar 

  121. J. Hao, G. Yuan, W. He, H. Cheng, C. C. Han, and C. Wu, Macromolecules 43, 2002 (2010).

    Article  CAS  Google Scholar 

  122. C. Esquenet and E. Buhler, Macromolecules 34, 5287 (2001).

    Article  CAS  Google Scholar 

  123. C. Esquenet, P. Terech, F. Boué, and E. Buhler, Langmuir 20, 3583 (2004).

    Article  CAS  Google Scholar 

  124. Y. Hu, Y. Du, J. Yang, Y. Tang, J. Li, and X. Wang, Polymer 48, 3098 (2007).

    Article  CAS  Google Scholar 

  125. G.-B. Jiang, D. Quan, K. Liao, and H. Wang, Mol. Pharm. 3, 152 (2006).

    Article  CAS  Google Scholar 

  126. K. Y. Lee, Y.-H. Kim, I. C. Kwon, and S. Y. Jeong, Colloid Polym. Sci. 278, 1216 (2000).

    Article  CAS  Google Scholar 

  127. J. You, F.-Q. Hu, Y.-Z. Du, and H. Yuan, Biomacromolecules 8, 2450 (2007).

    Article  CAS  Google Scholar 

  128. Y. Y. Li, X. G. Chen, C. S. Liu, D. S. Cha, H. J. Park, and C. M. Lee, J. Agric. Food Chem. 55, 4842 (2007).

    Article  CAS  Google Scholar 

  129. Y. S. Wang, L. R. Liu, Q. Jiang, and Q.-Q. Zhang, Eur. Polym. J. 43, 43 (2007).

    Article  CAS  Google Scholar 

  130. C. Zhang, Y. Ding, Q. Ping, and L. Yu, J. Agric. Food Chem. 54, 8409 (2006).

    Article  CAS  Google Scholar 

  131. S. Kwon, J. H. Park, H. Chung, I. C. Kwon, S. Y. Jeong, and I.-S. Kim, Langmuir 19, 10188 (2003).

    Article  CAS  Google Scholar 

  132. E. V. Korchagina and O. E. Philippova, Langmuir 28, 7880 (2012).

    Article  CAS  Google Scholar 

  133. K. Y. Lee, W. H. Jo, I. C. Kwon, Y.-H. Kim, and S. Y. Jeong, Macromolecules 31, 378 (1998).

    Article  CAS  Google Scholar 

  134. K. Y. Lee, I. C. Kwon, Y.-H. Kim, W. H. Jo, and S. Y. Jeong, J. Controlled Release 51, 213 (1998).

    Article  CAS  Google Scholar 

  135. X. Qu, V. V. Khutoryanskiy, A. Stewart, S. Rahman, B. Papahadjopoulos-Sternberg, C. Dufes, D. McCarthy, C. G. Wilson, R. Lyons, K. C. Carter, A. Schätzlein, and I. F. Uchegbu, Biomacromolecules 7, 3452 (2006).

    Article  CAS  Google Scholar 

  136. A. Halperin, J. Macromol. Sci., Part C: Polym. Rev. 46, 173 (2006).

    Article  CAS  Google Scholar 

  137. G. Bokias, V. V. Vasilevskaya, I. Iliopoulos, D. Hourdet, and A. R. Khokhlov, Macromolecules 33, 9757 (2000).

    Article  CAS  Google Scholar 

  138. A. S. Andreeva, O. E. Philippova, A. R. Khokhlov, A. Kh. Islamov, and A. I. Kuklin, Langmuir 21, 1216 (2005).

    Article  CAS  Google Scholar 

  139. M. Terbojevich, A. Cosani, G. Conio, E. Marsano, and E. Bianchi, Carbohydr. Polym. 209, 251 (1991).

    CAS  Google Scholar 

  140. K. Akiyoshi, S. Deguchi, H. Tajima, T. Nishikawa, and J. Sunamoto, Macromolecules 30, 857 (1997).

    Article  CAS  Google Scholar 

  141. M. S. Kök, A. S. Abdelhameed, S. Ang, G. A. Morris, and S. E. Harding, Food Hydrocolloids 23, 1910 (2009).

    Article  CAS  Google Scholar 

  142. T. Noda and Y. Morishima, Macromolecules 32, 4631 (1999).

    Article  CAS  Google Scholar 

  143. W. Burchard, Adv. Polym. Sci. 48, 1 (1983).

    Article  CAS  Google Scholar 

  144. M. Schmidt, D. Nerger, and W. Burchard, Polymer 20, 582 (1979).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Physics, Moscow State University, Moscow, 119991, Russia

    O. E. Philippova & E. V. Korchagina

Authors
  1. O. E. Philippova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Korchagina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. E. Philippova.

Additional information

Original Russian Text © O.E. Philippova, E.V. Korchagina, 2012, published in Vysokomolekulyarnye Soedineniya, Ser. A, 2012, Vol. 54, No. 7, pp. 1130–1152.

This work was supported by the federal target program Scientific and Educational Specialists of Innovation Russia for 2009–2013.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Philippova, O.E., Korchagina, E.V. Chitosan and its hydrophobic derivatives: Preparation and aggregation in dilute aqueous solutions. Polym. Sci. Ser. A 54, 552–572 (2012). https://doi.org/10.1134/S0965545X12060107

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0965545X12060107

Keywords

Search

Navigation