Skip to main content
SpringerLink
Log in

Hybridization of Gold Nanoparticles with Poly(ethylene glycol) Methacrylate and Their Biomedical Applications

  • PHYSICAL CHEMISTRY OF NANOCLUSTERS AND NANOMATERIALS
  • Published:
Russian Journal of Physical Chemistry A Aims and scope Submit manuscript

Abstract

The present project was envisioned towards comparative study gold nanoparticles synthesized using Periploca aphylla Dcne. extract (Pe-AuNPs) and poly(ethylene glycol) methacrylate coated AuNPs nanocomposites (PEGMA-AuNPs). For this purpose, Pe-AuNPs were prepared using green synthetic approach and then hybridized with PEGMA to form PEGMA-AuNPs. Both the neat and polymer-capped materials were characterized, investigated physico-chemically and the results were compared. Fourier transform infrared spectroscopy showed no new peak after the capping procedure, showing that only physical interactions take place during capping. The crystal structure of the AuNPs was not affected by PEGMA coating. After PEGMA capping, the spectra of the AuNPs red shifted (560–580 nm) and the overall particle size of AuNPs increased. Catalytic activity of the nanoparticles and hybrid system was tested by choosing the catalytic reduction of 4-nitrophenol [4-NP] as a model reaction. The synthesized AuNPs and polymer hybrid both exhibit catalytic activity in the reduction of 4‑NP to 4-aminophenol. Also the polymer hybrid exhibits remarkable antitumor, antioxidant, cytotoxic, antidiabetic and antileishmanial activities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.
Fig. 11.
Fig. 12.
Fig. 13.

Similar content being viewed by others

REFERENCES

  1. Y. Yang, Y. Lin, D. Di, et al., J. Colloid Interface Sci. 508, 323 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. M. N. Aktara, S. Das, S. Nayim, et al., Microchem. J. 147, 1163 (2019).

    Article  CAS  Google Scholar 

  3. N. Anwar, M. Shah, S. Saleem, et al., Bull. Chem. Soc. Ethiopia 32, 469 (2018).

    Article  CAS  Google Scholar 

  4. A. G. Rad, H. Abbasi, and M. H. Afzali, Phys. Proc. 22, 203 (2011).

    Article  Google Scholar 

  5. N. Kamaly, Z. Xiao, P. M. Valencia, et al., Chem. Soc. Rev. 41, 2971 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. J. Ding, L. Chen, C. Xiao, et al., Chem. Commun. 50, 11274 (2014).

    Article  CAS  Google Scholar 

  7. E. Mine, A. Yamada, Y. Kobayashi, et al., J. Colloid Interface Sci. 264, 385 (2003).

    Article  CAS  PubMed  Google Scholar 

  8. B. Masereel, M. Dinguizli, C. Bouzin, et al., J. Nanopart. Res. 13, 1573 (2011).

    Article  CAS  Google Scholar 

  9. S. O. Pereira, A. Barros-Timmons, and T. Trindade, Polymers 10, 189 (2018).

    Article  PubMed Central  Google Scholar 

  10. H. Chen, H. Zou, H. J. Paholak, et al., Polym. Chem. 5, 2768 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. L. J. Shearer and N. O. Petersen, Crystals 9, 544 (2019).

    Article  CAS  Google Scholar 

  12. J. T. Zhang, S. W. Huang, Y. N. Xue, et al., Macromol. Rapid Commun. 26, 1346 (2005).

    Article  CAS  Google Scholar 

  13. Q. Guo, R. Ghadiri, T. Weigel, et al., Polymers 6, 2037 (2014).

    Article  Google Scholar 

  14. J. Iqbal, S. Zaib, U. Farooq, et al., ISRN Pharmacol. 2012, (2012).

  15. A. Permadi, M. Z. Fahmi, J.-K. Chen, et al., RSC Adv. 2, 6018 (2012).

    Article  CAS  Google Scholar 

  16. H. K. Obied, M. S. Allen, D. R. Bedgood, et al., J. Agricult. Food Chem. 53, 823 (2005).

    Article  CAS  Google Scholar 

  17. V. Vidhu and D. Philip, Spectrochim. Acta, Part A 134, 372 (2015).

    Article  CAS  Google Scholar 

  18. I. Ul-Haq, N. Ullah, G. Bibi, et al., Iran. J. Parmac. Res. 11, 241 (2012).

    Google Scholar 

  19. K. Mahmood, Z. Akhter, M. A. Asghar, et al., J. Biomol. Struct. Dyn., 1 (2019).

  20. P. Sudha, S. S. Zinjarde, S. Y. Bhargava, et al., BMC Complem. Altern. Med. 11, 5 (2011).

    Article  Google Scholar 

  21. R. Anjana, R. Pradeepa, M. Deepa, et al., Diabetologia 54, 3022 (2011).

    Article  CAS  PubMed  Google Scholar 

  22. N. A. Shah, M. R. Khan, and A. Nadhman, BioMed Res. Int. 2014, 384204 (2014).

    PubMed  PubMed Central  Google Scholar 

  23. N. Ahmad, S. Sharma, V. Singh, et al., Biotechnol. Res. Int. 2011, 454090 (2011).

    Article  PubMed  Google Scholar 

  24. M. M. Khalil, E. H. Ismail, K. Z. El-Baghdady, et al., Arab. J. Chem. 7, 1131 (2014).

    Article  CAS  Google Scholar 

  25. S. Pandey, G. Oza, A. Mewada, et al., Arch. Appl. Sci. Res. 4, 1135 (2012).

    CAS  Google Scholar 

  26. N. Anwar, A. Khan, M. Shah, A. Azam, K. Zaman, and Z. Parven, Russ. J. Phys. Chem., A.: Focus Chem. 90, 2625 (2016).

  27. M. Vanaja, S. Rajeshkumar, K. Paulkumar, et al., Adv. Appl. Sci. Res. 4, 50 (2013).

    CAS  Google Scholar 

  28. M. Kaykhaii, N. Haghpazir, and J. Walisadeh, J. Nanostruct. 8, 152 (2018).

  29. I.-M. Chung, I. Park, K. Seung-Hyun, et al., Nanoscale Res. Lett. 11, 40 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  30. S. S. Naz, N. U. Islam, M. R. Shah, et al., J. Nanobiotechnol. 11, 13 (2013).

    Article  CAS  Google Scholar 

  31. I. Pastoriza-Santos and L. M. Liz-Marzán, Langmuir 18, 2888 (2002).

    Article  CAS  Google Scholar 

  32. D. Philip, Phys. E (Amsterdam, Neth.) 42, 1417 (2010).

  33. K. Cho, Y. Lee, C.-H. Lee, et al., J. Phys. Chem. C 112, 8629 (2008).

    Article  CAS  Google Scholar 

  34. M. R. Jones, K. D. Osberg, R. J. Macfarlane, et al., Chem. Rev. 111, 3736 (2011).

    Article  CAS  PubMed  Google Scholar 

  35. A. Rauf, M. Jan, W. Rehman, et al., Wudpecker J. Pharm. Pharmacol. 2, 21 (2013).

    Google Scholar 

  36. J. Safari, A. Enayati Najafabadi, Z. Zarnegar, et al., Green Chem. Lett. Rev. 9, 20 (2016).

    Article  CAS  Google Scholar 

  37. J. Markus, D. Wang, Y.-J. Kim, et al., Nanoscale Res. Lett. 12, 46 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  38. J. Park, J. Joo, S. G. Kwon, et al., Angew. Chem. Int. Ed. 46, 4630 (2007).

    Article  CAS  Google Scholar 

  39. C. Wohlfarth, CRC Handbook of Phase Equilibria and Thermodynamic Data of Aqueous Polymer Solutions (CRC, Boca Raton, FL, 2012).

    Book  Google Scholar 

  40. V. Jeevanantham, K. Hemalatha, and S. Satheeskumar, J. Ovonic Res. 14, 269 (2018).

  41. P. Agbo, P. Nwofe, and E. Ahworehe, Digest J. Nanomater. Biostruct. 12, 653 (2017).

    Google Scholar 

  42. Z.-X. Wang and S.-N. Ding, Anal. Chem. 86, 7436 (2014).

    Article  CAS  PubMed  Google Scholar 

  43. S. A. Cumberland and J. R. Lead, J. Chromatogr., A 1216, 9099 (2009).

  44. J. Huang, Q. Li, D. Sun, et al., Nanotechnology 18, 105104 (2007).

    Article  Google Scholar 

  45. M. E. Samberg, S. J. Oldenburg, and N. A. Monteiro-Riviere, Environ. Health Perspect. 118, 407 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  46. G. Singhal, R. Bhavesh, K. Kasariya, et al., J. Nanopart. Res. 13, 2981 (2011).

    Article  CAS  Google Scholar 

  47. K. Anandalakshmi, J. Venugobal, and V. Ramasamy, Appl. Nanosci. 6, 399 (2016).

    Article  CAS  Google Scholar 

  48. S. Sanyasi, R. K. Majhi, S. Kumar, et al., Sci. Rep. 6, 24929 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  49. V. Dave, R. B. Yadav, K. Kushwaha, et al., Bioactive Mater. 2, 269 (2017).

    Article  Google Scholar 

  50. S. Honary and F. Zahir, Tropic. J. Pharm. Res. 12, 255 (2013).

    Google Scholar 

  51. J. Ding, G. Chen, G. Chen, et al., Pharmaceutics 11, 123 (2019).

    Article  CAS  PubMed Central  Google Scholar 

  52. K. Sravanthi, D. Ayodhya, and P. Y. Swamy, Mater. Sci. Energy Technol. 2, 298 (2019).

    Google Scholar 

  53. T. K. Das, S. Ganguly, P. Bhawal, et al., Res. Chem. Intermed. 44, 1189 (2018).

    Article  CAS  Google Scholar 

  54. S. Nag, A. Pramanik, D. Chattopadhyay, et al., Environ. Sci. Pollut. Res. 25, 2331 (2018).

    Article  CAS  Google Scholar 

  55. H. Liu and Q. Yang, J. Mater. Chem. 21, 11961 (2011).

    Article  CAS  Google Scholar 

  56. L. Geng, S. Walter, and A. Vaughan, Int. J. Radiat. Oncol. Biol. Phys. 39, 243 (1997).

    Article  Google Scholar 

  57. M. Rehan, N. A. Abdel-Wahed, A. Farouk, et al., ACS Sustainable Chem. Eng. 6, 5911 (2018).

    Article  CAS  Google Scholar 

  58. A. Evangelatov, R. Skrobanska, N. Mladenov, et al., Drug Deliv. 23, 2235 (2016).

    Article  CAS  PubMed  Google Scholar 

  59. M. Akter, M. T. Sikder, M. M. Rahman, et al., J. Adv. Res. 9, 1 (2018).

    Article  CAS  PubMed  Google Scholar 

  60. T. ur Rehman, A.-u. Khan, A. Abbas, J. Hussain, F. U. Khan, K. Stieglitz, and Sh. Alie, Saudi Pharm. J. 26, 422 (2018).

  61. S. Jiang, D. Kai, Q. Q. Dou, et al., J. Mater. Chem. B 3, 6897 (2015).

    Article  CAS  PubMed  Google Scholar 

  62. R. Javed, M. Ahmed, I. ul Haq, et al., Mater. Sci. Eng. C 79, 108 (2017).

    Article  CAS  Google Scholar 

  63. S. R. Vijayan, P. Santhiyagu, M. Singamuthu, et al., Sci. World J. 2014, 131 (2014).

    Article  Google Scholar 

  64. N. Ahila, V. S. Ramkumar, S. Prakash, et al., Biomed. Pharmacother. 84, 60 (2016).

    Article  CAS  PubMed  Google Scholar 

  65. G. Liu, Y. Li, L. Yang, et al., RSC Adv. 7, 18252 (2017).

    Article  CAS  Google Scholar 

  66. M. P. Vinardell and M. Mitjans, Nanomaterials 5, 1004 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. S. Kavitha, K. Kannan, and S. Gnanavel, Saudi Pharm. J. 25, 337 (2017).

    Article  PubMed  Google Scholar 

  68. A. Ali, I. U. Haq, J. Akhtar, et al., IET Nanobiotechnol. 11, 477 (2016).

    Article  Google Scholar 

  69. A. Ali, S. Ambreen, Q. Maqbool, et al., J. Phys. Chem. Solids 98, 174 (2016).

    Article  CAS  Google Scholar 

  70. M. Gambucci, L. Tarpani, G. Zampini, et al., J. Phys. Chem. B 122, 6872 (2018).

    Article  CAS  PubMed  Google Scholar 

  71. J. K. Patra, G. Das, and H.-S. Shin, Int. J. Nanomed. 14, 6679 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Abdul Wali Khan University, 23200, Mardan, Pakistan

    Natasha Anwar & Abbas Khan

  2. Department of Botany, Abdul Wali Khan University, 23200, Mardan, Pakistan

    Mohib Shah

  3. School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland

    J. J. Walsh

  4. Department of Pharmacy, Abdul Wali Khan University, 23200, Mardan, Pakistan

    Z. Anwar

Authors
  1. Natasha Anwar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abbas Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohib Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. J. Walsh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Z. Anwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Natasha Anwar or Mohib Shah.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anwar, N., Khan, A., Shah, M. et al. Hybridization of Gold Nanoparticles with Poly(ethylene glycol) Methacrylate and Their Biomedical Applications. Russ. J. Phys. Chem. 95, 2619–2631 (2021). https://doi.org/10.1134/S0036024421130033

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0036024421130033

Keywords:

Search

Navigation