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Circulating microRNAs in lung cancer: Prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy

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Abstract

The review considers the main techniques to extract microRNA (miRNA) from various biological fluids (in particular, the serum and plasma), approaches to the analysis of miRNA concentration and composition, and methods to normalize the results in data analyses. Advantages and drawbacks of the methods are described. Special attention is given to circulating miRNAs, which can be used as markers for minimally invasive diagnosis, prediction of antitumor treatment efficacy, and disease prognosis in lung cancer. The review discusses the prospects and limitations that arise as the clinical significance is evaluated for miRNAs as potential tumor markers and a better understanding is gained for the roles various miRNAs play in the pathogenesis of lung cancer.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    V. V. Vlassov, E. Yu. Rykova, I. A. Zaporozhchenko, E. S. Morozkin & P. P. Laktionov

  2. Tomsk Cancer Research Institute, Tomsk, 634009, Russia

    A. A. Ponomaryova & N. V. Cherdyntseva

  3. National Research Tomsk State University, Tomsk, 634050, Russia

    N. V. Cherdyntseva

  4. National Research Polytechnic University, Tomsk, 634050, Russia

    A. A. Ponomaryova

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  1. V. V. Vlassov
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  2. E. Yu. Rykova
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  3. A. A. Ponomaryova
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  5. E. S. Morozkin
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Correspondence to E. Yu. Rykova.

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Original Russian Text © V.V. Vlassov, E.Yu. Rykova, A.A. Ponomaryova, I.A. Zaporozhchenko, E.S. Morozkin, N.V. Cherdyntseva, P.P. Laktionov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 1, pp. 55–66.

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Vlassov, V.V., Rykova, E.Y., Ponomaryova, A.A. et al. Circulating microRNAs in lung cancer: Prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy. Mol Biol 49, 48–57 (2015). https://doi.org/10.1134/S0026893315010161

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  • DOI: https://doi.org/10.1134/S0026893315010161

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