Abstract
TAAR1 is known as a neuromodulator of monoaminergic systems, providing the negative regulation of dopaminergic and serotonergic neuronal activity. The TAAR1 ability to regulate monoaminergic systems determines its prominent role in psychiatric and neurological disorders. The present study is aimed to provide further evidence for the role of TAAR1 in mismatch negativity (MMN) generation. The electroencephalogram was recorded in freely moving TAAR1 knockout and wild type mice. As the MMN response reflects a combination of stimulus-specific adaptation (SSA) and deviance detection (DD) response, we compare standard and deviant stimuli to the multi-standard control. The difference observed between the high-adapted standard and low-adapted control stimuli together with the similar response to deviant and control stimuli suggest that the MMN-like response in wild type mice most likely reflects the SSA. On the other hand, TAAR1 knockout mice show no difference between standard, deviant, and control stimuli, probably indicating that the SSA to repetitive stimuli is impaired in TAAR-KO mice.
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This work was supported by the Russian Science Foundation, project no. 22-25-00006.
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Conceptualization and experimental design (A.A.A., V.M.K.); data collection (E.S.D., N.V.P., Yu.A.S., L.N.S.); data processing (V.M.K., A.Yu.A.); writing and editing a manuscript (V.M.K., A.A.A., E.S.D.).
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Translated by A. Polyanovsky
Russian Text © The Author(s), 2022, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2022, Vol. 58, No. 3, pp. 232–239https://doi.org/10.31857/S0044452922030044.
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Knyazeva, V.M., Dmitrieva, E.S., Polyakova, N.V. et al. Stimulus Specific Adaptation Is Affected in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice. J Evol Biochem Phys 58, 692–699 (2022). https://doi.org/10.1134/S0022093022030061
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DOI: https://doi.org/10.1134/S0022093022030061