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Ceramide formation on the γ-irradiation of galactocerebroside as a constituent of micelles

  • Radiation Chemistry
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Abstract

The radiation-initiated transformations of galactocerebroside (GalCer) as a constituent of micelles were studied. The radiation-chemical yields of decomposition of the starting substrate and formation of degradation products suggested that the formation of ceramide is the main process in the γ-radiolysis of GalCer. The irradiation of GalCer in the presence of dimethyl sulfoxide, which is an active scavenger of OH radicals, decreased the yield of ceramide. Ceramide was formed as a result of GalCer degradation with O-glycoside bond cleavage in the polar moiety of the lipid.

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Authors and Affiliations

  1. Research Institute of Physicochemical Problems, Belarussian State University, ul. Leningradskaya 14, Minsk, 220080, Belarus

    I. L. Yurkova

  2. Institute of Medical Physics and Biophysics, Medical Department, Leipzig University, Härtelstrasse 16-18, D-04107, Leipzig, Germany

    J. Arnhold

Authors
  1. I. L. Yurkova
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  2. J. Arnhold
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Correspondence to I. L. Yurkova.

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Original Russian Text © I.L. Yurkova, J. Arnhold, 2008, published in Khimiya Vysokikh Energii, 2008, Vol. 42, No. 4, pp. 303–307.

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Yurkova, I.L., Arnhold, J. Ceramide formation on the γ-irradiation of galactocerebroside as a constituent of micelles. High Energy Chem 42, 261–265 (2008). https://doi.org/10.1134/S0018143908040036

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  • DOI: https://doi.org/10.1134/S0018143908040036

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