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Immune complexes that contain HIV antigens activate peripheral blood T cells

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Abstract

Uninfected donor T cells were treated in vitro by model immune complexes that contained either HIV or hepatitis C virus (HCV) antigens. Unlike HCV antigen-containing complexes, the immune complexes that contained HIV antigens have been shown to activate peripheral blood T cells of uninfected donors under in vitro conditions. Both the antiviral antibodies and HIV antigen were involved in the activation process. The unique properties of the immune complexes formed by HIV antigens and antiviral antibodies are believed to result from the virus-specific antibody properties and molecular conformation of the antigen–antibody complex.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia

    L. B. Korolevskaya, K. V. Shmagel & E. V. Saidakova

  2. Perm State National Research University, Perm, Russia

    L. B. Korolevskaya, K. V. Shmagel, E. V. Saidakova, N. G. Shmagel & V. A. Chereshnev

  3. Perm AIDS Center, Perm, Russia

    N. G. Shmagel

  4. Institute of Immunology and Physiology, Ural Dividion, Russian Academy of Sciences, Yekaterinburg, Russia

    V. A. Chereshnev

Authors
  1. L. B. Korolevskaya
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  2. K. V. Shmagel
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  3. E. V. Saidakova
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  4. N. G. Shmagel
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  5. V. A. Chereshnev
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Corresponding author

Correspondence to L. B. Korolevskaya.

Additional information

Original Russian Text © L.B. Korolevskaya, K.V. Shmagel, E.V. Saidakova, N.G. Shmagel, V.A. Chereshnev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 2, pp. 256–259.

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Korolevskaya, L.B., Shmagel, K.V., Saidakova, E.V. et al. Immune complexes that contain HIV antigens activate peripheral blood T cells. Dokl Biol Sci 469, 196–198 (2016). https://doi.org/10.1134/S0012496616040062

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  • DOI: https://doi.org/10.1134/S0012496616040062

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