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Evaluation of Thyroid Hormones-Thyrotropin Interrelationships in Thyroid Dysfunction States from Population-Based Data Analysis with a Logistic Model

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Abstract

Objective of this research is to explore the complex correlations among FT3, FT4 and TSH in thyroid dysfunction states. A total of 3425 outpatients were included to analyze their thyroid function tests measured at the university teaching hospital. The subjects under study were categorized as euthyroid (70.45%), subclinical hypothyroid (18.95%), overt hypothyroid (3.30%), subclinical hyperthyroid (5.11%) and overt hyperthyroid (2.19%) patients. The linear and non-linear relations among FT3, FT4 and TSH were modeled statistically to understand their role in thyroid functions. The prevalence of hypothyroidism is higher than hyperthyroidism in which females are more vulnerable than males. The correlation between FT3 and FT4 increases from euthyroidism (r = 0.1, P < 0.001) to overt thyroid dysfunctions (r = 0.91, P < 0.001). The non-linear complex correlations between FT4 and TSH are significantly explained by well fitted sigmoid curves of four-parameter logistic (4PL) model (R2 = 0.97 and P < 0.001) in both hypothyroidism and hyperthyroidism interfaced with euthyroidism. The 4PL curves are response trajectories of pituitary TSH which exhibit the turning points of thyroid dysfunction states by the deviation in serum FT4. The negative slopes and correlations observed in the linear fits in TSH vs FT3 or FT4 are the indicators of negative feedback mechanism in the thyroid cycle.

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Funding

This work was partially supported by Nepal Academy of Science and Technology (NAST) through a grant of PhD fellowship to the first author.

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Authors and Affiliations

  1. Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu, Nepal

    T. R. Lamichhane, S. P. Pant, B. Lamichhane & H. P. Lamichhane

  2. Department of Radiology & Imaging, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal

    S. Paudel

  3. Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal

    B. K. Yadav

Authors
  1. T. R. Lamichhane
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  2. S. P. Pant
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  3. B. Lamichhane
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  4. S. Paudel
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  5. B. K. Yadav
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  6. H. P. Lamichhane
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Correspondence to T. R. Lamichhane.

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COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interest. The authors declare that they have no conflicts of interest.

Statement of compliance with standards of research involving humans as subjects. This research work has been performed under the ethical guidelines provided by and taking authority from Institutional Review Board (IRB), Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal.

DATA AVAILABILITY

The data used to support the findings of this study are available from the corresponding author upon request.

Additional information

Abbreviations: FT3, serum free triiodothyronine; FT4, serum free teraiodothyronine; TSH, thyroid stimulating hormone or thyrotropin; TFT, thyroid function test; 4PL, four parameter logistic.

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Lamichhane, T.R., Pant, S.P., Lamichhane, B. et al. Evaluation of Thyroid Hormones-Thyrotropin Interrelationships in Thyroid Dysfunction States from Population-Based Data Analysis with a Logistic Model. BIOPHYSICS 67, 281–287 (2022). https://doi.org/10.1134/S0006350922020130

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