Abstract
Using Raman spectrometry and fluorescence microscopy, we studied the rearrangement of carotenoid molecules and membrane-bound Ca 2+mb in myelinated nerve fibers after K+ depolarization, K+-channel blocking, and altering the membrane protein conformation. We observed a decrease in Ca 2+mb and an increase of microviscosity in myelin after depolarization. Changes in Ca 2+mb and microviscosity were registered after blocking the K+ channels and modifying proteins with PCMB. Our results suggest an interconnection between the condition of nerve fiber membrane proteins, Ca 2+mb distribution, and myelin microviscosity.
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Original Russian Text © N.N. Rodionova, E.Z. Bibineyshvili, A.R. Brazhe, A.I. Yusipovich, G.V. Maksimov, A.B. Rubin, 2014, published in Biofizika, 2014, Vol. 59, No. 1, pp. 108–111.
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Rodionova, N.N., Bibineyshvili, E.Z., Brazhe, A.R. et al. Influence of nerve fiber K+ depolarization and altered membrane protein conformation on the state of myelin. BIOPHYSICS 59, 83–85 (2014). https://doi.org/10.1134/S0006350914010163
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DOI: https://doi.org/10.1134/S0006350914010163