Abstract
The potentialities of diffuse optical spectroscopy for noninvasive estimation of the oxygen status of experimental tumors have been demonstrated. The distribution of total, oxygenated, and deoxygenated hemoglobin, as well as the level of oxygen saturation of blood have been assessed using two tumor models differing in the histological structure and functional characteristics. The results obtained by the optical method have been verified by immunohistochemical examination of tissue specimens with an exogenous hypoxia marker pimonidazole.
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Abbreviations
- DOS:
-
diffuse optical spectroscopy
- IHC:
-
immunohistochemical
- Pim:
-
pimonidazole
- PLS:
-
Pliss lymphosarcoma
- RMC:
-
rat mammary cancer
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Original Russian Text © A.G. Orlova, A.V. Maslennikova, G.Yu. Golubyatnikov, V.A. Kamenskii, N.M. Shakhova, A.A. Babaev, L.B. Snopova, I.P. Ivanova, V.I. Plekhanov, T.I. Pryanikova, I.V. Turchin, 2011, published in Biofizika, 2011, Vol. 56, No. 2, pp. 349–355.
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Orlova, A.G., Maslennikova, A.V., Golubyatnikov, G.Y. et al. Noninvasive estimation of the oxygen status of experimental tumors by diffuse optical spectroscopy. BIOPHYSICS 56, 304–308 (2011). https://doi.org/10.1134/S0006350911020230
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DOI: https://doi.org/10.1134/S0006350911020230