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Multimodal Optical Diagnostics of Glycated Biological Tissues

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Abstract

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia accompanied by the disruption of carbohydrate, lipid, and proteins metabolism and development of long-term microvascular, macrovascular, and neuropathic changes. This review presents the results of spectroscopic studies on the glycation of tissues and cell proteins in organisms with naturally developing and model diabetes and in vitro glycated samples in a wide range of electromagnetic waves, from visible light to terahertz radiation. Experiments on the refractometric measurements of glycated and oxygenated hemoglobin in broad wavelength and temperature ranges using digital holographic microscopy and diffraction tomography are discussed, as well as possible application of these methods in the diabetes diagnostics. It is shown that the development and implementation of multimodal approaches based on a combination of phase diagnostics with other methods is another promising direction in the diabetes diagnostics. The possibilities of using optical clearing agents for monitoring the diffusion of substances in the glycated tissues and blood flow dynamics in the pancreas of animals with induced diabetes have also been analyzed.

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Abbreviations

AGEs:

advanced glycation end-products

CARS:

coherent anti-Stokes Raman scattering

HbA1c:

glycated (glycosylated) hemoglobin

HbO2 :

oxyhemoglobin

IR:

infrared

KKT:

Kramers–Kronig transform

MWPLS:

moving window partial least squares

NIR:

near-infrared

OCM:

optical coherence microscopy

OCT:

optical coherence tomography

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Authors and Affiliations

  1. ITMO University, 197101, St. Petersburg, Russia

    O. A. Smolyanskaya, S. S. Nalegaev, N. V. Petrov & V. V. Tuchin

  2. Saratov State University, 410012, Saratov, Russia

    E. N. Lazareva, P. A. Timoshina, D. K. Tuchina & V. V. Tuchin

  3. Tomsk State University, 634050, Tomsk, Russia

    E. N. Lazareva, P. A. Timoshina, D. K. Tuchina & V. V. Tuchin

  4. Prokhorov General Physics Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    K. I. Zaytsev & D. K. Tuchina

  5. Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    K. I. Zaytsev

  6. Bauman Moscow State Technical University, 105005, Moscow, Russia

    K. I. Zaytsev

  7. Almazov National Medical Research Centre, 197341, St. Petersburg, Russia

    Ya. G. Toropova, O. V. Kornyushin & A. Yu. Babenko

  8. IMS Laboratory, University of Bordeaux, 33405, Talence, France

    J.-P. Guillet

  9. Institute of Precision Mechanics and Control, Russian Academy of Sciences, 410028, Saratov, Russia

    V. V. Tuchin

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  1. O. A. Smolyanskaya
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Russian Text © O. A. Smolyanskaya, E. N. Lazareva, S. S. Nalegaev, N. V. Petrov, K. I. Zaytsev, P. A. Timoshina, D. K. Tuchina, Ya. G. Toropova, O. V. Kornyushin, A. Yu. Babenko, J.-P. Guillet, V. V. Tuchin, 2019, published in Uspekhi Biologicheskoi Khimii, 2019, Vol. 59, pp. 253–294.

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Smolyanskaya, O.A., Lazareva, E.N., Nalegaev, S.S. et al. Multimodal Optical Diagnostics of Glycated Biological Tissues. Biochemistry Moscow 84 (Suppl 1), 124–143 (2019). https://doi.org/10.1134/S0006297919140086

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