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Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment

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Abstract

Targeted drug delivery into the cell compartment that is the most vulnerable to effects of the corresponding drug is a challenging problem, and its successful solution can significantly increase the efficiency and reduce side effects of the delivered therapeutic agents. To accomplish this one can utilize natural mechanisms of cellular specific uptake of macromolecules by receptor-mediated endocytosis and intracellular transport between cellular compartments. A transporting construction combining the components responsible for different steps of intracellular transport is promising for creating multifunctional modular constructions capable of delivering the necessary therapeutic agent into a given compartment of type-specified cells. This review focuses on intracellular transport peculiarities along with approaches for designing such transporting constructions for new, more effective, and safer strategies for treatment of various diseases.

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Abbreviations

CPP:

cell penetration peptides

HMP:

hemoglobin-like protein of E. coli

MNT:

modular nanotransporters

NES:

nuclear export signal

NLS:

nuclear localization signal

PAA:

polyamidoamine

PEI:

polyethyleneimine

PS:

photosensitizer

ROS:

reactive oxygen species

TAT:

trans-activator of transcription

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 199334, Moscow, Russia

    A. A. Rosenkranz, A. V. Ulasov, T. A. Slastnikova, Y. V. Khramtsov & A. S. Sobolev

  2. Faculty of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia

    A. A. Rosenkranz & A. S. Sobolev

  3. Targeted Delivery of Pharmaceuticals “Translek” LLC, ul. Vavilova 34/5, 199334, Moscow, Russia

    A. V. Ulasov

Authors
  1. A. A. Rosenkranz
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  2. A. V. Ulasov
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  3. T. A. Slastnikova
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  4. Y. V. Khramtsov
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  5. A. S. Sobolev
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Correspondence to A. S. Sobolev.

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Original Russian Text © A. A. Rosenkranz, A. V. Ulasov, T. A. Slastnikova, Y. V. Khramtsov, A. S. Sobolev, 2014, published in Biokhimiya, 2014, Vol. 79, No. 9, pp. 1148–1168.

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Rosenkranz, A.A., Ulasov, A.V., Slastnikova, T.A. et al. Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment. Biochemistry Moscow 79, 928–946 (2014). https://doi.org/10.1134/S0006297914090090

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  • DOI: https://doi.org/10.1134/S0006297914090090

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