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Interaction between MAK-V protein kinase and synaptopodin

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Abstract

MAK-V protein kinase (also known as HUNK) was discovered more than decade ago but its functions and molecular mechanisms of action still remain mostly unknown. In an attempt to associate MAK-V with particular chains of molecular events, we searched for proteins interacting with the C-terminal domain of MAK-V protein kinase. We identified synaptopodin as a protein interaction partner for MAK-V and confirmed this interaction in various ways. Because synaptopodin is important for dendritic spine formation and plays a role in synaptic plasticity, our results might have significant impact on future studies for understanding the role of MAK-V in cells of the nervous system.

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Abbreviations

GAL4AD:

transcription activation domain of GAL4 transcription factor

GAL4BD:

DNA-binding domain of GAL4 transcription factor

GFP:

green fluorescent protein

GST:

glutathione S-transferase

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 119334, Moscow, Russia

    S. V. Kalinichenko, P. N. Vikhreva & I. V. Korobko

Authors
  1. S. V. Kalinichenko
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  2. P. N. Vikhreva
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  3. I. V. Korobko
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Corresponding author

Correspondence to S. V. Kalinichenko.

Additional information

Original Russian Text © S. V. Kalinichenko, P. N. Vikhreva, I. V. Korobko, 2011, published in Biokhimiya, 2011, Vol. 76, No. 2, pp. 238–244.

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Kalinichenko, S.V., Vikhreva, P.N. & Korobko, I.V. Interaction between MAK-V protein kinase and synaptopodin. Biochemistry Moscow 76, 196–201 (2011). https://doi.org/10.1134/S0006297911020052

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  • DOI: https://doi.org/10.1134/S0006297911020052

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