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Role of toll-like receptors in tissue repair and tumorigenesis

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Abstract

Toll-like receptors (TLRs) play a critical role in host defense from microbial infection. TLRs recognize conserved molecular structures produced by microorganisms and induce activation of innate and adaptive immune responses. The inflammatory responses induced by TLRs play an important role TLRs not only in host defense from infection, but also in tissue repair and regeneration. This latter function of TLRs can also contribute to tumorigenesis. Here we review recent progress in understanding the role of TLRs in cancer development.

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Abbreviations

LPS:

lipopolysaccharide

PAMPs:

pathogen-associated molecular patterns

PRRs:

pattern recognition receptors

TLRs:

Toll-like receptors

References

  1. Peek, R. M., Jr., and Blaser, M. J. (2002) Nat. Rev. Cancer, 2, 28–37.

    PubMed  CAS  Google Scholar 

  2. Schiffman, M., Castle, P. E., Jeronimo, J., Rodriguez, A. C., and Wacholder, S. (2007) Lancet, 370, 890–907.

    PubMed  CAS  Google Scholar 

  3. Balkwill, F., and Mantovani, A. (2001) Lancet, 357, 539–545.

    PubMed  CAS  Google Scholar 

  4. Coussens, L. M., and Werb, Z. (2002) Nature, 420, 860–867.

    PubMed  CAS  Google Scholar 

  5. Kinzler, K. W., and Vogelstein, B. (1996) Cell, 87, 159–170.

    PubMed  CAS  Google Scholar 

  6. Dvorak, H. F. (1986) Nat. Engl. J. Med., 315, 1650–1659.

    CAS  Google Scholar 

  7. Beachy, P. A., Karhadkar, S. S., and Berman, D. M. (2004) Nature, 432, 324–331.

    PubMed  CAS  Google Scholar 

  8. Medzhitov, R. (2007) Nature, 449, 819–826.

    PubMed  CAS  Google Scholar 

  9. Meylan, E., Tschopp, J., and Karin, M. (2006) Nature, 442, 39–44.

    PubMed  CAS  Google Scholar 

  10. Lee, M. S., and Kim, Y. J. (2007) Annu. Rev. Biochem., 76, 447–480.

    PubMed  CAS  Google Scholar 

  11. Janeway, C. A., Jr. (1989) Cold Spring Harb. Symp. Quant. Biol., 54, 1–13.

    PubMed  CAS  Google Scholar 

  12. Roach, J. C., Glusman, G., Rowen, L., Kaur, A., Purcell, M. K., Smith, K. D., Hood, L. E., and Aderem, A. (2005) Proc. Natl. Acad. Sci. USA, 102, 9577–9582.

    PubMed  CAS  Google Scholar 

  13. Miyake, K. (2007) Semin. Immunol., 19, 3–10.

    PubMed  CAS  Google Scholar 

  14. Ohashi, K., Burkart, V., Flohe, S., and Kolb, H. (2000) J. Immunol., 164, 558–561.

    PubMed  CAS  Google Scholar 

  15. Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Hacker, H., and Wagner, H. (2001) J. Biol. Chem., 276, 31332–31339.

    PubMed  CAS  Google Scholar 

  16. Vabulas, R. M., Ahmad-Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., and Wagner, H. (2002) J. Biol. Chem., 277, 15107–15112.

    PubMed  CAS  Google Scholar 

  17. Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Bare, O., Auron, P. E., Stevenson, M. A., and Calderwood, S. K. (2002) J. Biol. Chem., 277, 15028–15034.

    PubMed  CAS  Google Scholar 

  18. Dybdahl, B., Wahba, A., Lien, E., Flo, T. H., Waage, A., Qureshi, N., Sellevold, O. F., Espevik, T., and Sundan, A. (2002) Circulation, 105, 685–690.

    PubMed  CAS  Google Scholar 

  19. Vabulas, R. M., Braedel, S., Hilf, N., Singh-Jasuja, H., Herter, S., Ahmad-Nejad, P., Kirschning, C. J., da Costa, C., Rammensee, H. G., Wagner, H., and Schild, H. (2002) J. Biol. Chem., 277, 20847–20853.

    PubMed  CAS  Google Scholar 

  20. Roelofs, M. F., Boelens, W. C., Joosten, L. A., Abdollahi-Roodsaz, S., Geurts, J., Wunderink, L. U., Schreurs, B. W., van den Berg, W. B., and Radstake, T. R. (2006) J. Immunol., 176, 7021–7027.

    PubMed  CAS  Google Scholar 

  21. Park, J. S., Gamboni-Robertson, F., He, Q., Svetkauskaite, D., Kim, J. Y., Strassheim, D., Sohn, J. W., Yamada, S., Maruyama, I., Banerjee, A., Ishizaka, A., and Abraham, E. (2006) Am. J. Physiol. Cell Physiol., 290, C917–C924.

    PubMed  CAS  Google Scholar 

  22. Park, J. S., Svetkauskaite, D., He, Q., Kim, J. Y., Strassheim, D., Ishizaka, A., and Abraham, E. (2004) J. Biol. Chem., 279, 7370–7377.

    PubMed  CAS  Google Scholar 

  23. Liu-Bryan, R., Scott, P., Sydlaske, A., Rose, D. M., and Terkeltaub, R. (2005) Arthritis Rheum., 52, 2936–2946.

    PubMed  CAS  Google Scholar 

  24. Liu-Bryan, R., Pritzker, K., Firestein, G. S., and Terkeltaub, R. (2005) J. Immunol., 174, 5016–5023.

    PubMed  CAS  Google Scholar 

  25. Guillot, L., Balloy, V., McCormack, F. X., Golenbock, D. T., Chignard, M., and Si-Tahar, M. (2002) J. Immunol., 168, 5989–5992.

    PubMed  CAS  Google Scholar 

  26. Okamura, Y., Watari, M., Jerud, E. S., Young, D. W., Ishizaka, S. T., Rose, J., Chow, J. C., and Strauss, J. F., 3rd (2001) J. Biol. Chem., 276, 10229–10233.

    PubMed  CAS  Google Scholar 

  27. Johnson, G. B., Brunn, G. J., Kodaira, Y., and Platt, J. L. (2002) J. Immunol., 168, 5233–5239.

    PubMed  CAS  Google Scholar 

  28. Schaefer, L., Babelova, A., Kiss, E., Hausser, H. J., Baliova, M., Krzyzankova, M., Marsche, G., Young, M. F., Mihalik, D., Gotte, M., Malle, E., Schaefer, R. M., and Grone, H. J. (2005) J. Clin. Invest., 115, 2223–2233.

    PubMed  CAS  Google Scholar 

  29. Smiley, S. T., King, J. A., and Hancock, W. W. (2001) J. Immunol., 167, 2887–2894.

    PubMed  CAS  Google Scholar 

  30. Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., and Simon, J. C. (2002) J. Exp. Med., 195, 99–111.

    PubMed  CAS  Google Scholar 

  31. Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., Homer, R. J., Goldstein, D. R., Bucala, R., Lee, P. J., Medzhitov, R., and Noble, P. W. (2005) Nat. Med., 11, 1173–1179.

    PubMed  CAS  Google Scholar 

  32. Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., and Gallo, R. L. (2004) J. Biol. Chem., 279, 17079–17084.

    PubMed  CAS  Google Scholar 

  33. Taylor, K. R., Yamasaki, K., Radek, K. A., di Nardo, A., Goodarzi, H., Golenbock, D., Beutler, B., and Gallo, R. L. (2007) J. Biol. Chem., 282, 18265–18275.

    PubMed  CAS  Google Scholar 

  34. Kawasaki, K., Akashi, S., Shimazu, R., Yoshida, T., Miyake, K., and Nishijima, M. (2000) J. Biol. Chem., 275, 2251–2254.

    PubMed  CAS  Google Scholar 

  35. Kawasaki, K., Gomi, K., and Nishijima, M. (2001) J. Immunol., 166, 11–14.

    PubMed  CAS  Google Scholar 

  36. Byrd-Leifer, C. A., Block, E. F., Takeda, K., Akira, S., and Ding, A. (2001) Eur. J. Immunol., 31, 2448–2457.

    PubMed  CAS  Google Scholar 

  37. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., and Akira, S. (2002) Nat. Immunol., 3, 196–200.

    PubMed  CAS  Google Scholar 

  38. Heil, F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., and Bauer, S. (2003) Eur. J. Immunol., 33, 2987–2997.

    PubMed  CAS  Google Scholar 

  39. Takeda, K., Kaisho, T., and Akira, S. (2003) Annu. Rev. Immunol., 21, 335–376.

    PubMed  CAS  Google Scholar 

  40. Martin, M., Katz, J., Vogel, S. N., and Michalek, S. M. (2001) J. Immunol., 167, 5278–5285.

    PubMed  CAS  Google Scholar 

  41. Martin, M., Rehani, K., Jope, R. S., and Michalek, S. M. (2005) Nat. Immunol., 6, 777–784.

    PubMed  CAS  Google Scholar 

  42. Monick, M. M., Carter, A. B., Robeff, P. K., Flaherty, D. M., Peterson, M. W., and Hunninghake, G. W. (2001) J. Immunol., 166, 4713–4720.

    PubMed  CAS  Google Scholar 

  43. Thiele, A., Wasner, M., Muller, C., Engeland, K., and Hauschildt, S. (2001) J. Immunol., 167, 6786–6793.

    PubMed  CAS  Google Scholar 

  44. Anderson, K. V., Bokla, L., and Nusslein-Volhard, C. (1985) Cell, 42, 791–798.

    PubMed  CAS  Google Scholar 

  45. Hashimoto, C., Hudson, K. L., and Anderson, K. V. (1988) Cell, 52, 269–279.

    PubMed  CAS  Google Scholar 

  46. Rose, D., Zhu, X., Kose, H., Hoang, B., Cho, J., and Chiba, A. (1997) Development, 124, 1561–1571.

    PubMed  CAS  Google Scholar 

  47. Foster, J. S., Apicella, M. A., and McFall-Ngai, M. J. (2000) Dev. Biol., 226, 242–254.

    PubMed  CAS  Google Scholar 

  48. Bates, J. M., Mittge, E., Kuhlman, J., Baden, K. N., Cheesman, S. E., and Guillemin, K. (2006) Dev. Biol., 297, 374–386.

    PubMed  CAS  Google Scholar 

  49. Cheesman, S. E., and Guillemin, K. (2007) Res. Microbiol., 158, 2–9.

    PubMed  Google Scholar 

  50. Larsen, P. H., Holm, T. H., and Owens, T. (2007) Sci. STKE, 47.

  51. Michelsen, K. S., and Arditi, M. (2007) Curr. Opin. Hematol., 14, 48–54.

    PubMed  CAS  Google Scholar 

  52. Rolls, A., Shechter, R., London, A., Ziv, Y., Ronen, A., Levy, R., and Schwartz, M. (2007) Nat. Cell Biol., 9, 1081–1088.

    PubMed  CAS  Google Scholar 

  53. Ma, Y., Li, J., Chiu, I., Wang, Y., Sloane, J. A., Lu, J., Kosaras, B., Sidman, R. L., Volpe, J. J., and Vartanian, T. (2006) J. Cell Biol., 175, 209–215.

    PubMed  CAS  Google Scholar 

  54. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., and Medzhitov, R. (2004) Cell, 118, 229–241.

    PubMed  CAS  Google Scholar 

  55. Cario, E., Gerken, G., and Podolsky, D. K. (2004) Gastroenterology, 127, 224–238.

    PubMed  CAS  Google Scholar 

  56. Cario, E., Gerken, G., and Podolsky, D. K. (2007) Gastroenterology, 132, 1359–1374.

    PubMed  CAS  Google Scholar 

  57. Fukata, M., Michelsen, K. S., Eri, R., Thomas, L. S., Hu, B., Lukasek, K., Nast, C. C., Lechago, J., Xu, R., Naiki, Y., Soliman, A., Arditi, M., and Abreu, M. T. (2005) Am. J. Physiol. Gastrointest. Liver Physiol., 288, G1055–G1065.

    PubMed  CAS  Google Scholar 

  58. Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., and Stappenbeck, T. S. (2005) Proc. Natl. Acad. Sci. USA, 102, 99–104.

    PubMed  CAS  Google Scholar 

  59. Araki, A., Kanai, T., Ishikura, T., Makita, S., Uraushihara, K., Iiyama, R., Totsuka, T., Takeda, K., Akira, S., and Watanabe, M. (2005) J. Gastroenterol., 40, 16–23.

    PubMed  CAS  Google Scholar 

  60. Gibson, D. L., Ma, C., Rosenberger, C. M., Bergstrom, K. S., Valdez, Y., Huang, J. T., Khan, M. A., and Vallance, B. A. (2008) Cell Microbiol., 10, 388–403.

    PubMed  CAS  Google Scholar 

  61. Seki, E., Tsutsui, H., Iimuro, Y., Naka, T., Son, G., Akira, S., Kishimoto, T., Nakanishi, K., and Fujimoto, J. (2005) Hepatology, 41, 443–450.

    PubMed  CAS  Google Scholar 

  62. Campbell, J. S., Riehle, K. J., Brooling, J. T., Bauer, R. L., Mitchell, C., and Fausto, N. (2006) J. Immunol., 176, 2522–2528.

    PubMed  CAS  Google Scholar 

  63. Zhang, X., Shan, P., Qureshi, S., Homer, R., Medzhitov, R., Noble, P. W., and Lee, P. J. (2005) J. Immunol., 175, 4834–4838.

    PubMed  CAS  Google Scholar 

  64. Kigerl, K. A., Lai, W., Rivest, S., Hart, R. P., Satoskar, A. R., and Popovich, P. G. (2007) J. Neurochem., 102, 37–50.

    PubMed  CAS  Google Scholar 

  65. Babcock, A. A., Wirenfeldt, M., Holm, T., Nielsen, H. H., Dissing-Olesen, L., Toft-Hansen, H., Millward, J. M., Landmann, R., Rivest, S., Finsen, B., and Owens, T. (2006) J. Neurosci., 26, 12826–12837.

    PubMed  CAS  Google Scholar 

  66. Kim, D., Kim, M. A., Cho, I. H., Kim, M. S., Lee, S., Jo, E. K., Choi, S. Y., Park, K., Kim, J. S., Akira, S., Na, H. S., Oh, S. B., and Lee, S. J. (2007) J. Biol. Chem., 282, 14975–14983.

    PubMed  CAS  Google Scholar 

  67. Fukata, M., Chen, A., Klepper, A., Krishnareddy, S., Vamadevan, A. S., Thomas, L. S., Xu, R., Inoue, H., Arditi, M., Dannenberg, A. J., and Abreu, M. T. (2006) Gastroenterology, 131, 862–877.

    PubMed  CAS  Google Scholar 

  68. Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., and Stappenbeck, T. S. (2007) J. Clin. Invest., 117, 258–269.

    PubMed  CAS  Google Scholar 

  69. Zhang, Z., and Schluesener, H. J. (2006) Cell Mol. Life Sci., 63, 2901–2907.

    PubMed  CAS  Google Scholar 

  70. Pevsner-Fischer, M., Morad, V., Cohen-Sfady, M., Rousso-Noori, L., Zanin-Zhorov, A., Cohen, S., Cohen, I. R., and Zipori, D. (2007) Blood, 109, 1422–1432.

    PubMed  CAS  Google Scholar 

  71. Mollen, K. P., Anand, R. J., Tsung, A., Prince, J. M., Levy, R. M., and Billiar, T. R. (2006) Shock, 26, 430–437.

    PubMed  CAS  Google Scholar 

  72. Seki, E., de Minicis, S., Osterreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., and Schwabe, R. F. (2007) Nat. Med., 13, 1324–1332.

    PubMed  CAS  Google Scholar 

  73. Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., Yang, H., Amigorena, S., Ryffel, B., Barrat, F. J., Saftig, P., Levi, F., Lidereau, R., Nogues, C., Mira, J. P., Chompret, A., Joulin, V., Clavel-Chapelon, F., Bourhis, J., Andre, F., Delaloge, S., Tursz, T., Kroemer, G., and Zitvogel, L. (2007) Nat. Med., 13, 1050–1059.

    PubMed  CAS  Google Scholar 

  74. Scaffidi, P., Misteli, T., and Bianchi, M. E. (2002) Nature, 418, 191–195.

    PubMed  CAS  Google Scholar 

  75. Jiang, D., Liang, J., Li, Y., and Noble, P. W. (2006) Cell Res., 16, 693–701.

    PubMed  CAS  Google Scholar 

  76. Garay, R. P., Viens, P., Bauer, J., Normier, G., Bardou, M., Jeannin, J. F., and Chiavaroli, C. (2007) Eur. J. Pharmacol., 563, 1–17.

    PubMed  CAS  Google Scholar 

  77. Coley, W. B. (1991) Clin. Orthop. Relat. Res., 262, 3–11.

    PubMed  Google Scholar 

  78. Okamoto, H., Shoin, S., Koshimura, S., and Shimizu, R. (1967) Jpn. J. Microbiol., 11, 323–326.

    PubMed  CAS  Google Scholar 

  79. Kikkawa, F., Kawai, M., Oguchi, H., Kojima, M., Ishikawa, H., Iwata, M., Maeda, O., Tomoda, Y., Arii, Y., Kuzuya, K., et al. (1993) Eur. J. Cancer, 29A, 1542–1546.

    PubMed  CAS  Google Scholar 

  80. Maehara, Y., Okuyama, T., Kakeji, Y., Baba, H., Furusawa, M., and Sugimachi, K. (1994) Am. J. Surg., 168, 36–40.

    PubMed  CAS  Google Scholar 

  81. Sato, M., Harada, K., Yoshida, H., Yura, Y., Azuma, M., Iga, H., Bando, T., Kawamata, H., and Takegawa, Y. (1997) Apoptosis, 2, 227–238.

    PubMed  CAS  Google Scholar 

  82. Okamoto, M., Oshikawa, T., Tano, T., Ahmed, S. U., Kan, S., Sasai, A., Akashi, S., Miyake, K., Moriya, Y., Ryoma, Y., Saito, M., and Sato, M. (1997) J. Immunother., 29, 78–86.

    Google Scholar 

  83. Hironaka, K., Yamaguchi, Y., Okita, R., Okawaki, M., and Nagamine, I. (2006) Anticancer Res., 26, 3701–3707.

    PubMed  CAS  Google Scholar 

  84. Razack, A. H. (2007) Asian J. Surg., 30, 302–309.

    PubMed  Google Scholar 

  85. Tsuji, S., Matsumoto, M., Takeuchi, O., Akira, S., Azuma, I., Hayashi, A., Toyoshima, K., and Seya, T. (2000) Infect. Immun., 68, 6883–6890.

    PubMed  CAS  Google Scholar 

  86. Uehori, J., Fukase, K., Akazawa, T., Uematsu, S., Akira, S., Funami, K., Shingai, M., Matsumoto, M., Azuma, I., Toyoshima, K., Kusumoto, S., and Seya, T. (2005) J. Immunol., 174, 7096–7103.

    PubMed  CAS  Google Scholar 

  87. Krieg, A. M. (2007) J. Clin. Invest., 117, 1184–1194.

    PubMed  CAS  Google Scholar 

  88. Otto, F., Schmid, P., Mackensen, A., Wehr, U., Seiz, A., Braun, M., Galanos, C., Mertelsmann, R., and Engelhardt, R. (1996) Eur. J. Cancer, 32A, 1712–1718.

    PubMed  CAS  Google Scholar 

  89. Chicoine, M. R., Zahner, M., Won, E. K., Kalra, R. R., Kitamura, T., Perry, A., and Higashikubo, R. (2007) Neurosurgery, 60, 372–380.

    PubMed  Google Scholar 

  90. Sfondrini, L., Rossini, A., Besusso, D., Merlo, A., Tagliabue, E., Menard, S., and Balsari, A. (2006) J. Immunol., 176, 6624–6630.

    PubMed  CAS  Google Scholar 

  91. Scheel, B., Aulwurm, S., Probst, J., Stitz, L., Hoerr, I., Rammensee, H. G., Weller, M., and Pascolo, S. (2006) Eur. J. Immunol., 36, 2807–2816.

    PubMed  CAS  Google Scholar 

  92. Stockfleth, E., Trefzer, U., Garcia-Bartels, C., Wegner, T., Schmook, T., and Sterry, W. (2003) Br. J. Dermatol., 149, 53–56.

    PubMed  CAS  Google Scholar 

  93. Spaner, D. E., and Masellis, A. (2007) Leukemia, 21, 53–60.

    PubMed  CAS  Google Scholar 

  94. Carpentier, A., Laigle-Donadey, F., Zohar, S., Capelle, L., Behin, A., Tibi, A., Martin-Duverneuil, N., Sanson, M., Lacomblez, L., Taillibert, S., Puybasset, L., van Effenterre, R., Delattre, J. Y., and Carpentier, A. F. (2006) Neuro. Oncol., 8, 60–66.

    PubMed  CAS  Google Scholar 

  95. Salaun, B., Coste, I., Rissoan, M. C., Lebecque, S. J., and Renno, T. (2006) J. Immunol., 176, 4894–4901.

    PubMed  CAS  Google Scholar 

  96. El Andaloussi, A., Sonabend, A. M., Han, Y., and Lesniak, M. S. (2006) Glia, 54, 526–535.

    PubMed  Google Scholar 

  97. Haimovitz-Friedman, A., Cordon-Cardo, C., Bayoumy, S., Garzotto, M., McLoughlin, M., Gallily, R., Edwards, C. K., 3rd, Schuchman, E. H., Fuks, Z., and Kolesnick, R. (1997) J. Exp. Med., 186, 1831–1841.

    PubMed  CAS  Google Scholar 

  98. Nogueras, S., Merino, A., Ojeda, R., Carracedo, J., Rodriguez, M., Martin-Malo, A., Ramirez, R., and Aljama, P. (2008) Am. J. Physiol. Heart Circ. Physiol., 294, H708–713.

    PubMed  CAS  Google Scholar 

  99. Smyth, M. J., Dunn, G. P., and Schreiber, R. D. (2006) Adv. Immunol., 90, 1–50.

    PubMed  CAS  Google Scholar 

  100. Akazawa, T., Ebihara, T., Okuno, M., Okuda, Y., Shingai, M., Tsujimura, K., Takahashi, T., Ikawa, M., Okabe, M., Inoue, N., Okamoto-Tanaka, M., Ishizaki, H., Miyoshi, J., Matsumoto, M., and Seya, T. (2007) Proc. Natl. Acad. Sci. USA, 104, 252–257.

    PubMed  CAS  Google Scholar 

  101. Tsan, M. F. (2006) Semin. Cancer Biol., 16, 32–37.

    PubMed  CAS  Google Scholar 

  102. Chen, K., Huang, J., Gong, W., Iribarren, P., Dunlop, N. M., and Wang, J. M. (2007) Int. Immunopharmacol., 7, 1271–1285.

    PubMed  CAS  Google Scholar 

  103. Gaudreault, E., Fiola, S., Olivier, M., and Gosselin, J. (2007) J. Virol., 81, 8016–8024.

    PubMed  CAS  Google Scholar 

  104. Wu, J., Lu, M., Meng, Z., Trippler, M., Broering, R., Szczeponek, A., Krux, F., Dittmer, U., Roggendorf, M., Gerken, G., and Schlaak, J. F. (2007) Hepatology, 46, 1769–1778.

    PubMed  CAS  Google Scholar 

  105. Dolganiuc, A., Oak, S., Kodys, K., Golenbock, D. T., Finberg, R. W., Kurt-Jones, E., and Szabo, G. (2004) Gastroenterology, 127, 1513–1524.

    PubMed  CAS  Google Scholar 

  106. Chang, S., Dolganiuc, A., and Szabo, G. (2007) J. Leukoc. Biol., 82, 479–487.

    PubMed  CAS  Google Scholar 

  107. Yang, R., Murillo, F. M., Cui, H., Blosser, R., Uematsu, S., Takeda, K., Akira, S., Viscidi, R. P., and Roden, R. B. (2004) J. Virol., 78, 11152–11160.

    PubMed  CAS  Google Scholar 

  108. Ferrero, R. L. (2005) Mol. Immunol., 42, 879–885.

    PubMed  CAS  Google Scholar 

  109. Pidgeon, G. P., Harmey, J. H., Kay, E., Da Costa, M., Redmond, H. P., and Bouchier-Hayes, D. J. (1999) Br. J. Cancer, 81, 1311–1317.

    PubMed  CAS  Google Scholar 

  110. Harmey, J. H., Bucana, C. D., Lu, W., Byrne, A. M., McDonnell, S., Lynch, C., Bouchier-Hayes, D., and Dong, Z. (2002) Int. J. Cancer, 101, 415–422.

    PubMed  CAS  Google Scholar 

  111. Luo, J. L., Maeda, S., Hsu, L.C., Yagita, H., and Karin, M. (2004) Cancer Cell, 6, 297–305.

    PubMed  CAS  Google Scholar 

  112. Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., Mayer, L., Unkeless, J., Li, D., Yuan, Y., Zhang, G. M., Xiong, H., and Feng, Z. H. (2007) Cancer Res., 67, 4346–4352.

    PubMed  CAS  Google Scholar 

  113. Jego, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., and Pellat-Deceunynck, C. (2006) Leukemia, 20, 1130–1137.

    PubMed  CAS  Google Scholar 

  114. Bohnhorst, J., Rasmussen, T., Moen, S. H., Flottum, M., Knudsen, L., Borset, M., Espevik, T., and Sundan, A. (2006) Leukemia, 20, 1138–1144.

    PubMed  CAS  Google Scholar 

  115. Huang, B., Zhao, J., Li, H., He, K. L., Chen, Y., Chen, S. H., Mayer, L., Unkeless, J. C., and Xiong, H. (2005) Cancer Res., 65, 5009–5014.

    PubMed  CAS  Google Scholar 

  116. Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., and Karin, M. (2007) Science, 317, 121–124.

    PubMed  CAS  Google Scholar 

  117. Maeda, S., Kamata, H., Luo, J. L., Leffert, H., and Karin, M. (2005) Cell, 121, 977–990.

    PubMed  CAS  Google Scholar 

  118. Rakoff-Nahoum, S., and Medzhitov, R. (2007) Science, 317, 124–127.

    PubMed  CAS  Google Scholar 

  119. Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., and Taketo, M. M. (1996) Cell, 87, 803–809.

    PubMed  CAS  Google Scholar 

  120. Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., and Langenbach, R. (2000) Cancer Res., 60, 4705–4708.

    PubMed  CAS  Google Scholar 

  121. Wilson, C. L., Heppner, K. J., Labosky, P. A., Hogan, B. L., and Matrisian, L. M. (1997) Proc. Natl. Acad. Sci. USA, 94, 1402–1407.

    PubMed  CAS  Google Scholar 

  122. Hong, K. H., Bonventre, J. C., O’Leary, E., Bonventre, J. V., and Lander, E. S. (2001) Proc. Natl. Acad. Sci. USA, 98, 3935–3939.

    PubMed  CAS  Google Scholar 

  123. Kuper, H., Adami, H. O., and Trichopoulos, D. (2000) J. Int. Med., 248, 171–183.

    CAS  Google Scholar 

  124. Coley, W. B. (1898) Ann. Surg., 27, 259–284.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Memorial Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 06510, USA

    S. Rakoff-Nahoum & R. Medzhitov

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  1. S. Rakoff-Nahoum
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  2. R. Medzhitov
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Correspondence to R. Medzhitov.

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Published in Russian in Biokhimiya, 2008, Vol. 73, No. 5, pp. 690–698.

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Rakoff-Nahoum, S., Medzhitov, R. Role of toll-like receptors in tissue repair and tumorigenesis. Biochemistry Moscow 73, 555–561 (2008). https://doi.org/10.1134/S0006297908050088

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