Abstract
The connection between the efficiency of phenolic lipids and their hydrophobic property (solubility) and hydrophobic property of microorganisms’ cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20–50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25–100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure-number, position, and length of alkyl substituents-is studied.
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Original Russian Text © Yu.A. Nikolaev, I.A. Borzenkov, M.V. Kalinin, N.G. Loiko, A.L. Tarasov, V.K. Plakunov, S.S. Belyaev, N.V. Voronina, V.F. Gal’chenko, G.I. El’-Registan, 2010, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2010, Vol. 46, No. 2, pp. 172–179.
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Nikolaev, Y.A., Borzenkov, I.A., Kalinin, M.V. et al. Antimicrobic features of phenolic lipids. Appl Biochem Microbiol 46, 159–165 (2010). https://doi.org/10.1134/S0003683810020067
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DOI: https://doi.org/10.1134/S0003683810020067