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The Role of Serum Albumin in the Conduction of a Regulatory Signal in Mammals

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This review presents data on the study of the structure, physicochemical properties, and biological activity of extracellular protein-peptide complexes that participate in intercellular adhesion and activate cellular sources of regeneration in vertebrate tissues. Protein-peptide complex consists of certain isoforms of serum albumin and peptides—products of the proteolysis of known membrane and adhesion proteins. The biological effect of protein-peptide complexes is characterized by the presence of tissue specificity and dose dependence but a lack of species specificity. In solutions, protein-peptide complexes are in the form of nanosized particles; this state is associated with the manifestation of biological activity of the protein-peptide complex. A possible mechanism of the protein-peptide complex structure and its interaction with the cell plasma membrane is considered.

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Funding

This study was supported by the Ministry of Science and Eduction of the Russian Federation.

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  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

    M. S. Krasnov

  2. Institute of Problems of Bioregulation, Moscow, Russia

    A. P. Ilyina & V. P. Yamskova

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  2. A. P. Ilyina
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Krasnov, M.S., Ilyina, A.P. & Yamskova, V.P. The Role of Serum Albumin in the Conduction of a Regulatory Signal in Mammals. Biol Bull Rev 11 (Suppl 1), 19–31 (2021). https://doi.org/10.1134/S2079086421070057

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